PIN1 promoter polymorphism (842 G>C) contributes to a decreased risk of cancer: Evidence from meta‑analysis

  • Authors:
    • Liang‑Jun Tao
    • Yi‑Sheng Chen
    • Lei Yao
    • Bin Zou
    • Ling‑Song Tao
    • Jian Kong
    • Ying‑Qing Liu
    • Qiang Cao
    • Chang‑Jun Yin
  • View Affiliations

  • Published online on: June 24, 2014     https://doi.org/10.3892/ol.2014.2280
  • Pages: 1360-1366
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Abstract

Peptidyl‑prolylcis‑trans isomerase NIMA‑interacting 1 (encoded by the PIN1 gene) regulates the conformation of proline‑directed phosphorylation sites and is important in the etiology of cancer. Since the identification of a functional polymorphism of PIN1, (‑842 G>C; rs2233678), in the PIN1 promoter region, numerous studies have evaluated the association between the PIN1 promoter polymorphism (‑842 G>C) and cancer risk. However, the available results are inconclusive. To derive a more precise estimation, a meta‑analysis of seven previous case‑control studies was performed, which included 4,524 cases exhibiting different tumor types and 4,561 control subjects. The published literature was retrieved from PubMed and EMBASE. Crude odds ratios (ORs) with 95% confidence intervals (CIs) were calculated to evaluate the strength of the association. Overall, the results of the present study demonstrated that individuals carrying the variant C allele (G/C and C/C) were associated with a significantly decreased cancer risk (OR, 0.75; 95% CI, 0.62‑0.90 for GC vs. GG; OR, 0.75; 95% CI, 0.64‑0.88 for GC/CC vs. GG). In further stratified analyses, a decreased cancer risk was observed in the following subgroups: Breast and lung cancer patients, Asian individuals, and in studies with a sample size >500. The results indicated that the PIN1 promoter polymorphism (‑842 G>C; rs2233678) contributes to a decreased risk of cancer via attenuating the transcriptional activity.
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September-2014
Volume 8 Issue 3

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Spandidos Publications style
Tao LJ, Chen YS, Yao L, Zou B, Tao LS, Kong J, Liu YQ, Cao Q and Yin CJ: PIN1 promoter polymorphism (842 G>C) contributes to a decreased risk of cancer: Evidence from meta‑analysis. Oncol Lett 8: 1360-1366, 2014
APA
Tao, L., Chen, Y., Yao, L., Zou, B., Tao, L., Kong, J. ... Yin, C. (2014). PIN1 promoter polymorphism (842 G>C) contributes to a decreased risk of cancer: Evidence from meta‑analysis. Oncology Letters, 8, 1360-1366. https://doi.org/10.3892/ol.2014.2280
MLA
Tao, L., Chen, Y., Yao, L., Zou, B., Tao, L., Kong, J., Liu, Y., Cao, Q., Yin, C."PIN1 promoter polymorphism (842 G>C) contributes to a decreased risk of cancer: Evidence from meta‑analysis". Oncology Letters 8.3 (2014): 1360-1366.
Chicago
Tao, L., Chen, Y., Yao, L., Zou, B., Tao, L., Kong, J., Liu, Y., Cao, Q., Yin, C."PIN1 promoter polymorphism (842 G>C) contributes to a decreased risk of cancer: Evidence from meta‑analysis". Oncology Letters 8, no. 3 (2014): 1360-1366. https://doi.org/10.3892/ol.2014.2280