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Print ISSN: 1792-1074 Online ISSN: 1792-1082
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September-2014 Volume 8 Issue 3

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Case Report

Tracheal adenoid cystic carcinoma mimicking a thyroid tumor: A case report

  • Authors:
    • Wojciech Kukwa
    • Piotr Korzeń
    • Piotr Wojtowicz
    • Grzegorz  Sobczyk
    • Dorota Kiprian
    • Andrzej Kawecki
    • Andrzej Kukwa
    • Antoni  Krzeski
    • Cezary Szczylik
    • Anna M. Czarnecka
  • View Affiliations / Copyright

    Affiliations: Department of Otolaryngology, Czerniakowski Hospital, Medical University of Warsaw, Warsaw 00‑739, Poland, Department of Oncology, Military Institute of Medicine, Warsaw 04‑141, Poland, The Maria Sklodowska Curie Memorial Cancer Centre and Institute of Oncology, Warsaw 02‑781, Poland, Department of Otolaryngology and Head and Neck Disease, University of Varmia and Masuria School of Medicine, Olsztyn 10‑561, Poland
  • Pages: 1312-1316
    |
    Published online on: June 25, 2014
       https://doi.org/10.3892/ol.2014.2282
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Abstract

At present, only eight cases of tracheal adenoid cystic carcinomas (ACCs) mimicking thyroid tumors have been reported. Since there are no guidelines available regarding their diagnosis and treatment, they present a significant clinical challenge. In the present study, patient treatment was analyzed to deliver the first concise summary of treatment options in patients with ACC mimicking a thyroid tumor. In addition, all available data regarding molecular abnormalities of this disease have been discussed. The current study presents a case of a 17‑year‑old patient with a tracheal ACC mimicking a thyroid tumor. The patient was diagnosed in 2007 with a pathological mass between the left lobe of the thyroid and the trachea, and underwent surgery and radiotherapy. In 2010, multiple lesions in the lungs were diagnosed and pulmonary metastasectomy was performed. Following surgery, the patient has been disease‑free for almost 30 months. Thyroid tumor biopsy may reveal ACCs. This pathological report requires further investigation of the head and neck in order to confirm if the disease is of tracheal origin. Patients may present with a neck swelling, hoarseness of voice or dysphagia. Surgery must be considered as first‑line therapy for all patients with local disease as it may be curative. For palliative treatment chemoradiotherapy based on cisplatin may be effective. The identification of cytogenetics, tumor suppressor genes, oncogenes, epigenetic alterations and mitochondrial abnormalities specific for ACCs is critical to the development of targeted therapies. Thus far, large studies have only reported the transcriptional activator Myb and mammalian target of rapamycin signaling pathway to be disrupted in ACCs.
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Copy and paste a formatted citation
Spandidos Publications style
Kukwa W, Korzeń P, Wojtowicz P, Sobczyk G, Kiprian D, Kawecki A, Kukwa A, Krzeski A, Szczylik C, Czarnecka AM, Czarnecka AM, et al: Tracheal adenoid cystic carcinoma mimicking a thyroid tumor: A case report. Oncol Lett 8: 1312-1316, 2014.
APA
Kukwa, W., Korzeń, P., Wojtowicz, P., Sobczyk, G., Kiprian, D., Kawecki, A. ... Czarnecka, A.M. (2014). Tracheal adenoid cystic carcinoma mimicking a thyroid tumor: A case report. Oncology Letters, 8, 1312-1316. https://doi.org/10.3892/ol.2014.2282
MLA
Kukwa, W., Korzeń, P., Wojtowicz, P., Sobczyk, G., Kiprian, D., Kawecki, A., Kukwa, A., Krzeski, A., Szczylik, C., Czarnecka, A. M."Tracheal adenoid cystic carcinoma mimicking a thyroid tumor: A case report". Oncology Letters 8.3 (2014): 1312-1316.
Chicago
Kukwa, W., Korzeń, P., Wojtowicz, P., Sobczyk, G., Kiprian, D., Kawecki, A., Kukwa, A., Krzeski, A., Szczylik, C., Czarnecka, A. M."Tracheal adenoid cystic carcinoma mimicking a thyroid tumor: A case report". Oncology Letters 8, no. 3 (2014): 1312-1316. https://doi.org/10.3892/ol.2014.2282
Copy and paste a formatted citation
x
Spandidos Publications style
Kukwa W, Korzeń P, Wojtowicz P, Sobczyk G, Kiprian D, Kawecki A, Kukwa A, Krzeski A, Szczylik C, Czarnecka AM, Czarnecka AM, et al: Tracheal adenoid cystic carcinoma mimicking a thyroid tumor: A case report. Oncol Lett 8: 1312-1316, 2014.
APA
Kukwa, W., Korzeń, P., Wojtowicz, P., Sobczyk, G., Kiprian, D., Kawecki, A. ... Czarnecka, A.M. (2014). Tracheal adenoid cystic carcinoma mimicking a thyroid tumor: A case report. Oncology Letters, 8, 1312-1316. https://doi.org/10.3892/ol.2014.2282
MLA
Kukwa, W., Korzeń, P., Wojtowicz, P., Sobczyk, G., Kiprian, D., Kawecki, A., Kukwa, A., Krzeski, A., Szczylik, C., Czarnecka, A. M."Tracheal adenoid cystic carcinoma mimicking a thyroid tumor: A case report". Oncology Letters 8.3 (2014): 1312-1316.
Chicago
Kukwa, W., Korzeń, P., Wojtowicz, P., Sobczyk, G., Kiprian, D., Kawecki, A., Kukwa, A., Krzeski, A., Szczylik, C., Czarnecka, A. M."Tracheal adenoid cystic carcinoma mimicking a thyroid tumor: A case report". Oncology Letters 8, no. 3 (2014): 1312-1316. https://doi.org/10.3892/ol.2014.2282
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