Conservative management of endometrial stromal sarcoma at stage III: A case report

Dong,Ruiying; Mao,Hongluan; Zhang,Peihai

doi:10.3892/ol.2014.2288

Conservative management of endometrial stromal sarcoma at stage III: A case report

Authors:
- Ruiying Dong
- Hongluan Mao
- Peihai Zhang
View Affiliations

Affiliations: Department of Obstetrics and Gynecology, Qilu Hospital of Shandong University, Jinan, Shandong 250012, P.R. China
Published online on: June 26, 2014 https://doi.org/10.3892/ol.2014.2288
Pages: 1234-1236

Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )

Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )

Cited By (CrossRef): 0 citations Loading Articles...

Abstract

Endometrial stromal sarcoma (ESS) is a rare malignant tumor of the uterus. The standard treatment is surgery, such as total hysterectomy with bilateral salpingo‑oophorectomy. The use of adjuvant treatment, including chemotherapy, radiation therapy and endocrine therapy, remains controversial, so it is uncommon for conservative management to be performed in patients with low‑grade ESS. The present study reports the case of a 19‑year‑old female with ESS at stage III who underwent a local mass resection by laparoscopic surgery. A high dose of progestin (medroxyprogesterone acetate) therapy was then administered. Conservative management resulted in complete remission of the low‑grade ESS, with no sign of recurrence at the 33‑month follow‑up.

View Figures

View References

1	Nam JH: Surgical treatment of uterine sarcoma. Best Pract Res Clin Obstet Gynaecol. 25:751–760. 2011.
2	Tropé CG, Abeler VM and Kristensen GB: Diagnosis and treatment of sarcoma of the uterus. A review. Acta Oncol. 51:694–705. 2012.
3	Amant F, Vergote I and Moerman P: The classification of a uterine sarcoma as ‘high-grade endometrial stromal sarcoma’ should be abandoned. Gynecol Oncol. 95:412–413. 2004.
4	Yan L, Tian Y, Fu Y and Zhao X: Successful pregnancy after fertility-preserving surgery for endometrial stromal sarcoma. Fertil Steril. 93:269.e1–269.e3. 2010.
5	Delaney AA, Gubbels AL, Remmenga S, Tomich P and Molpus K: Successful pregnancy after fertility-sparing local resection and uterine reconstruction for low-grade endometrial stromal sarcoma. Obstet Gynecol. 120:486–489. 2012.
6	Koskas M, Morice P, Yazbeck C, Duvillard P, Walker F and Madelenat P: Conservative management of low-grade endometrial stromal sarcoma followed by pregnancy and severe recurrence. Anticancer Res. 29:4147–4150. 2009.
7	Dong R, Pang Y, Mao H, Yang N and Liu P: Successful pregnancy following conservative management of low-grade endometrial stromal sarcoma: A case report. Oncol Lett. 7:1039–1042. 2014.
8	Yalman D, Ozsaran Z, Baltalarli B, Demir O, Ozdemir N and Aras A: Results of postoperative radiotherapy in the treatment of uterine sarcomas: a retrospective analysis of 46 patients. Eur J Gynaecol Oncol. 29:46–51. 2008.
9	Chang KL, Crabtree GS, Lim-Tan SK, Kempson RL and Hendrickson MR: Primary uterine endometrial stromal neoplasms. A clinicopathologic study of 117 cases. Am J Surg Pathol. 14:415–438. 1990.
10	Amant F, Coosemans A, Debiec-Rychter M, Timmerman D and Vergote I: Clinical management of uterine sarcomas. Lancet Oncol. 10:1188–1198. 2009.
11	Chu MC, Mor G, Lim C, Zheng W, Parkash V and Schwartz PE: Low-grade endometrial stromal sarcoma: hormonal aspects. Gynecol Oncol. 90:170–176. 2003.
12	Sylvestre VT and Dunton CJ: Treatment of recurrent endometrial stromal sarcoma with letrozole: a case report and literature review. Horm Cancer. 1:112–115. 2010.
13	Leiser AL, Hamid AM and Blanchard R: Recurrence of prolactin-producing endometrial stromal sarcoma with sex-cord stromal component treated with progestin and aromatase inhibitor. Gynecol Oncol. 94:567–571. 2004.
14	Spano JP, Soria JC, Kambouchner M, et al: Long-term survival of patients given hormonal therapy for metastatic endometrial stromal sarcoma. Med Oncol. 20:87–93. 2003.