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September-2014 Volume 8 Issue 3

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Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

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Article

Effect of daphnoretin on the proliferation and apoptosis of A549 lung cancer cells in vitro

  • Authors:
    • Hong‑Fang Jiang
    • Zhuo Wu
    • Xue Bai
    • Yi Zhang
    • Ping He
  • View Affiliations / Copyright

    Affiliations: Department of Geriatrics, Shengjing Hospital of China Medical University, Shenyang, Liaoning 110004, P.R. China, Department of Thoracic Surgery, The Fourth Affiliated Hospital of China Medical University, Shenyang, Liaoning 110004, P.R. China
  • Pages: 1139-1142
    |
    Published online on: June 30, 2014
       https://doi.org/10.3892/ol.2014.2296
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Abstract

Daphnoretin is an active constituent of Wikstroemia indica C.A. Mey., which is widely distributed in the northwest and southwest regions of China. Previous studies have shown that daphnoretin has anticancer effects on leukemia, osteosarcoma and uterine cervix cancer cells. However, the effect of daphnoretin on human lung cancer cells has yet to be elucidated. In the present study, daphnoretin was observed to inhibit A549 lung cancer cell proliferation in a concentration‑ and time‑dependent manner. Fluorescent microscopy and flow cytometric analysis showed that daphnoretin induced A549 cell apoptosis in a concentration‑dependent manner. Western blot analysis also revealed that daphnoretin induced apoptosis through the regulation of the B‑cell lymphoma‑2 gene family in A549 cells. These findings indicate that daphnoretin may have potential as a therapeutic agent for the management of lung cancer.
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Copy and paste a formatted citation
Spandidos Publications style
Jiang HF, Wu Z, Bai X, Zhang Y and He P: Effect of daphnoretin on the proliferation and apoptosis of A549 lung cancer cells in vitro. Oncol Lett 8: 1139-1142, 2014.
APA
Jiang, H., Wu, Z., Bai, X., Zhang, Y., & He, P. (2014). Effect of daphnoretin on the proliferation and apoptosis of A549 lung cancer cells in vitro. Oncology Letters, 8, 1139-1142. https://doi.org/10.3892/ol.2014.2296
MLA
Jiang, H., Wu, Z., Bai, X., Zhang, Y., He, P."Effect of daphnoretin on the proliferation and apoptosis of A549 lung cancer cells in vitro". Oncology Letters 8.3 (2014): 1139-1142.
Chicago
Jiang, H., Wu, Z., Bai, X., Zhang, Y., He, P."Effect of daphnoretin on the proliferation and apoptosis of A549 lung cancer cells in vitro". Oncology Letters 8, no. 3 (2014): 1139-1142. https://doi.org/10.3892/ol.2014.2296
Copy and paste a formatted citation
x
Spandidos Publications style
Jiang HF, Wu Z, Bai X, Zhang Y and He P: Effect of daphnoretin on the proliferation and apoptosis of A549 lung cancer cells in vitro. Oncol Lett 8: 1139-1142, 2014.
APA
Jiang, H., Wu, Z., Bai, X., Zhang, Y., & He, P. (2014). Effect of daphnoretin on the proliferation and apoptosis of A549 lung cancer cells in vitro. Oncology Letters, 8, 1139-1142. https://doi.org/10.3892/ol.2014.2296
MLA
Jiang, H., Wu, Z., Bai, X., Zhang, Y., He, P."Effect of daphnoretin on the proliferation and apoptosis of A549 lung cancer cells in vitro". Oncology Letters 8.3 (2014): 1139-1142.
Chicago
Jiang, H., Wu, Z., Bai, X., Zhang, Y., He, P."Effect of daphnoretin on the proliferation and apoptosis of A549 lung cancer cells in vitro". Oncology Letters 8, no. 3 (2014): 1139-1142. https://doi.org/10.3892/ol.2014.2296
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