Isolated duodenal myeloid sarcoma associated with the CBFβ/MYH11 fusion gene followed by acute myeloid leukemia progression: A case report and literature review

  • Authors:
    • Bo Huang
    • Peng You
    • Ping Zhu
    • Zunguo Du
    • Beiqian Wu
    • Xiaoping Xu
    • Zi Chen
  • View Affiliations

  • Published online on: July 4, 2014     https://doi.org/10.3892/ol.2014.2313
  • Pages: 1261-1264
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

Myeloid sarcoma (MS) is a rare disease that presents as an extramedullary tumorous mass of immature myeloid precursors. The majority of MS are identified in acute myeloid leukemia (AML) patients and rarely present as a primary isolated MS without AML. In addition, inversion of chromosome 16 [inv(16)] and the CBFβ/MYH11 fusion gene are rarely associated with MS. The current study reports a female patient with an isolated duodenal MS, who developed AML‑M4 associated with the CBFβ/MYH11 fusion gene and 48,XX,inv(16),+13,+22. A review of previously reported cases of isolated MS with the CBFβ/MYH11 fusion gene was also performed. Isolated MS with the CBFβ/MYH11 fusion gene was often observed in abdominal lesions, with the intestinal tract being the predominantly involved site. In addition, patients with isolated MS with the CBFβ/MYH11 fusion exhibited a high risk of developing systemic AML. The diagnosis of isolated MS may be particularly challenging and, therefore, determining the optimal standard treatment for isolated MS is required.
View Figures
View References

Related Articles

Journal Cover

September-2014
Volume 8 Issue 3

Print ISSN: 1792-1074
Online ISSN:1792-1082

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
x
Spandidos Publications style
Huang B, You P, Zhu P, Du Z, Wu B, Xu X and Chen Z: Isolated duodenal myeloid sarcoma associated with the CBFβ/MYH11 fusion gene followed by acute myeloid leukemia progression: A case report and literature review. Oncol Lett 8: 1261-1264, 2014
APA
Huang, B., You, P., Zhu, P., Du, Z., Wu, B., Xu, X., & Chen, Z. (2014). Isolated duodenal myeloid sarcoma associated with the CBFβ/MYH11 fusion gene followed by acute myeloid leukemia progression: A case report and literature review. Oncology Letters, 8, 1261-1264. https://doi.org/10.3892/ol.2014.2313
MLA
Huang, B., You, P., Zhu, P., Du, Z., Wu, B., Xu, X., Chen, Z."Isolated duodenal myeloid sarcoma associated with the CBFβ/MYH11 fusion gene followed by acute myeloid leukemia progression: A case report and literature review". Oncology Letters 8.3 (2014): 1261-1264.
Chicago
Huang, B., You, P., Zhu, P., Du, Z., Wu, B., Xu, X., Chen, Z."Isolated duodenal myeloid sarcoma associated with the CBFβ/MYH11 fusion gene followed by acute myeloid leukemia progression: A case report and literature review". Oncology Letters 8, no. 3 (2014): 1261-1264. https://doi.org/10.3892/ol.2014.2313