Chemotherapy‑induced fulminant acute pancreatitis in pancreatic carcinoma: A case report
- Authors:
- Linghui Lu
- Yanni Lou
- Huangying Tan
View Affiliations
Affiliations: Department of Traditional Chinese Medicine Oncology, China‑Japan Friendship Hospital, Beijing 100029, P.R. China
- Published online on: July 4, 2014 https://doi.org/10.3892/ol.2014.2316
-
Pages:
1143-1146
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Abstract
Cases of chemotherapy‑induced pancreatitis are rarely reported and among those diagnosed, the majority are mild and self‑limiting. However, no previous cases of fulminant acute pancreatitis (FAP) induced by chemotherapeutic agents have been reported. The current study presents a case of FAP in a 62‑year‑old female on gemcitabine and capecitabine therapy. The patient was admitted to the China‑Japan Friendship Hospital (Beijing, China) with the symptoms of acute pancreatitis two days after the completion of the first cycle of chemotherapy. Shock, hypoxemia and acute renal failure supervened, which resulted in mortality. As the common etiologies of pancreatitis were eliminated, a correlation between the incidence of FAP, and pancreatic cancer or chemotherapy, or both was suspected. Clinicians should be aware of this potential adverse effect when prescribing chemotherapeutic agents, particularly in patients with pre‑existing risk factors for pancreatitis.
View References
1
|
Cheng L and Wang XP: Changes in etiology,
diagnosis and therapeutics in patients with acute pancreatitis
during the past ten years: A retrospective study of 725 cases. Wei
Chang Bing Xue. 5:280–283. 2004.(In Chinese).
|
2
|
Nitsche CJ, Jamieson N, Lerch MM and
Mayerle JV: Drug induced pancreatitis. Best Pract Res Clin
Gastroenterol. 24:143–155. 2010.
|
3
|
Jones KL and Valero V:
Capecitabine-induced pancreatitis. Pharmacotherapy. 23:1076–1078.
2003.
|
4
|
Yucel H and Warmerdam LV:
Capecitabine-induced pancreatitis. J Oncol Pharm Pract. 16:133–134.
2010.
|
5
|
Chan HY, Ng CM, Tiu SC, Chan OK and Shek
CC: Hypertriglyceridaemia-induced pancreatitis: a contributory role
of capecitabine? Hong Kong Med J. 18:526–529. 2012.
|
6
|
Hoff PM, Valero V, Holmes FA, Whealin H,
Hudis C and Hortobagyi GN: Paclitaxel-induced pancreatitis: a case
report. J Natl Cancer Inst. 89:91–93. 1997.
|
7
|
Kumar DM, Sundar S and Vasanthan S: A case
of paclitaxel-induced pancreatitis. Clin Oncol (R Coll Radiol).
15:352003.
|
8
|
Elouni B, Ben Salem C, Zamy M, Sakhri J,
Bouraoui K and Biour M: Bortezomib-induced acute pancreatitis. JOP.
11:275–276. 2010.
|
9
|
Solakoglu T, Akyol P, Guney T, et al:
Acute pancreatitis caused by bortezomib. Pancreatol. 13:189–190.
2013.
|
10
|
Tester W, Forbes W and Leighton J:
Vinorelbine-induced pancreatitis: a case report. J Natl Cancer
Inst. 89:16311997.
|
11
|
Izraeli S, Adamson PC, Blaney SM and Balis
FM: Acute pancreatitis after ifosfamide therapy. Cancer.
74:1627–1628. 1994.
|
12
|
Gerson R, Serrano A, Villalobos A,
Sternbach GL and Varon J: Acute pancreatitis secondary to
ifosfamide. J Emerg Med. 15:645–647. 1997.
|
13
|
Hung MC, Hung GY, Lin PC, Tiu CM and Tien
YC: Acute pancreatitis associated with ifosfamide. J Chin Med
Assoc. 70:176–179. 2007.
|
14
|
Grag R, Agarwala S and Bhatnagar V: Acute
pancreatitis induced by ifosfamide therapy. J Pediatr Surg.
45:2071–2073. 2010.
|
15
|
Badalov N, Baradarian R, Iswara K, Li J,
Steinberg W and Tenner S: Drug-induced acute pancreatitis: an
evidence-based review. Clin Gastroenterol Hepatol. 5:648–661.
2007.
|