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October 2014 Volume 8 Issue 4

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International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

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International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

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Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

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Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

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Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

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Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

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Article

Hyperleukocytosis: A report of five cases and review of the literature

  • Authors:
    • Junmei Gong
    • Bijia Wu
    • Tianjian Guo
    • Silang Zhou
    • Benfu He
    • Xinzhao Peng

  • View Affiliations / Copyright

    Affiliations: Department of Haematology, Chinese People's Liberation Army No. 421 Hospital, Guangzhou, Guangdong 510310, P.R. China
  • Pages: 1825-1827
    |
    Published online on: July 8, 2014
       https://doi.org/10.3892/ol.2014.2326
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Abstract

Hyperleukocytosis (white blood cell count, >100x109/l), an uncommon presentation of leukemia, is associated with an increased risk of early mortality. It may present with a variety of symptoms secondary to leukostasis, a syndrome caused by the sludging of circulating leukemic blasts in the microvasculature. Adequate measures for managing this medical emergency include hydration, cytoreduction, prevention of tumor lysis and, rarely, leukapheresis in cases complicated by leukostasis and hyperviscosity syndrome. The present study reports a case series of five patients with hyperleukocytic leukemia. In addition, a review of the literature with regard to the incidence, pathophysiology, clinical manifestations and management of this laboratory abnormality is included. This study demonstrated that the central nervous system and lungs are the most common sites for leukostasis, and that emergency cases require aggressive treatment.
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Oliveira LC, Romano LG, Prado-Junior BP, et al: Outcome of acute myeloid leukemia patients with hyperleukocytosis in Brazil. Med Oncol. 27:1254–1259. 2010.

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Piro E, Carillio G, Levato L, Kropp M and Molica S: Reversal of leukostasis-related pulmonary distress syndrome after leukapheresis and low-dose chemotherapy in acute myeloid leukemia. J Clin Oncol. 29:e725–e726. 2011.

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Inaba H, Fan Y, Pounds S, et al: Clinical and biologic features and treatment outcome of children with newly diagnosed acute myeloid leukemia and hyperleukocytosis. Cancer. 113:522–529. 2008.

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Copy and paste a formatted citation
Spandidos Publications style
Gong J, Wu B, Guo T, Zhou S, He B and Peng X: Hyperleukocytosis: A report of five cases and review of the literature. Oncol Lett 8: 1825-1827, 2014.
APA
Gong, J., Wu, B., Guo, T., Zhou, S., He, B., & Peng, X. (2014). Hyperleukocytosis: A report of five cases and review of the literature. Oncology Letters, 8, 1825-1827. https://doi.org/10.3892/ol.2014.2326
MLA
Gong, J., Wu, B., Guo, T., Zhou, S., He, B., Peng, X."Hyperleukocytosis: A report of five cases and review of the literature". Oncology Letters 8.4 (2014): 1825-1827.
Chicago
Gong, J., Wu, B., Guo, T., Zhou, S., He, B., Peng, X."Hyperleukocytosis: A report of five cases and review of the literature". Oncology Letters 8, no. 4 (2014): 1825-1827. https://doi.org/10.3892/ol.2014.2326
Copy and paste a formatted citation
x
Spandidos Publications style
Gong J, Wu B, Guo T, Zhou S, He B and Peng X: Hyperleukocytosis: A report of five cases and review of the literature. Oncol Lett 8: 1825-1827, 2014.
APA
Gong, J., Wu, B., Guo, T., Zhou, S., He, B., & Peng, X. (2014). Hyperleukocytosis: A report of five cases and review of the literature. Oncology Letters, 8, 1825-1827. https://doi.org/10.3892/ol.2014.2326
MLA
Gong, J., Wu, B., Guo, T., Zhou, S., He, B., Peng, X."Hyperleukocytosis: A report of five cases and review of the literature". Oncology Letters 8.4 (2014): 1825-1827.
Chicago
Gong, J., Wu, B., Guo, T., Zhou, S., He, B., Peng, X."Hyperleukocytosis: A report of five cases and review of the literature". Oncology Letters 8, no. 4 (2014): 1825-1827. https://doi.org/10.3892/ol.2014.2326
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