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Article

XELIRI compared with FOLFIRI as a second‑line treatment in patients with metastatic colorectal cancer

  • Authors:
    • Chengxu Cui
    • Chang Shu
    • Yi Yang
    • Junbao Liu
    • Shuping Shi
    • Zhujun  Shao
    • Nan Wang
    • Ting Yang
    • Songnian Hu
  • View Affiliations / Copyright

    Affiliations: Department of Oncology, Cancer Institute and Hospital, Chinese Academy of Medical Sciences, Beijing 100021, P.R. China, CAS Key Laboratory of Genome Sciences and Information, Beijing Institute of Genomics, Chinese Academy of Sciences, Beijing 100101, P.R. China, Department of Oncology, Beijing Chaoyang San Huan Cancer Hospital, Beijing 100122, P.R. China
  • Pages: 1864-1872
    |
    Published online on: July 10, 2014
       https://doi.org/10.3892/ol.2014.2335
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Abstract

The aim of this study was to compare the efficacy, safety and survival rate of a treatment regimen comprising capecitabine plus irinotecan (XELIRI) to those of a standard regimen comprising leucovorin, fluorouracil and irinotecan (FOLFIRI), to determine the correlation among the inherited genetic variations in UGT1A1, UGT1A7 and UGT1A9. A total of 84 consecutive patients with histologically confirmed metastatic colorectal cancer (mCRC) were included in the study. All patients were treated with FOLFIRI or XELIRI. The median progression‑free survival time was 4.4 months for FOLFIRI and 5.7 months for XELIRI (hazard ratio=1.35; 95% confidence interval, 0.83‑2.21; P=0.22). When compared with FOLFIRI (6.34%), XELIRI was associated with lower rates of severe toxicity (3.29) (P=0.026) and similar disease control rates (69.57% for FOLFIRI and 61.11% for XELIRI; P=0.49). In total, 17 single nucleotide polymorphisms were identified, five of which revealed an association with grade 3/4 neutropenia, including UGT1A7*4; however, UGT1A1*28 and UGT1A1*6, which have been previously reported, were not significant. Additionally, H2 haplotypes, which include UGT1A9*22, and H5 and H7 haplotypes, which include UGT1A7*2, UGT1A7*3 and UGT1A7*4, were associated with a higher risk of severe neutropenia. In conclusion, XELIRI is an effective treatment regimen with acceptable response rates and tolerability for mCRC patients as a second‑line treatment. Furthermore, inherited genetic variations in UGT1A1, UGT1A7 and UGT1A9 are associated with grade 3/4 neutropenia.
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Copy and paste a formatted citation
Spandidos Publications style
Cui C, Shu C, Yang Y, Liu J, Shi S, Shao Z, Wang N, Yang T and Hu S: XELIRI compared with FOLFIRI as a second‑line treatment in patients with metastatic colorectal cancer. Oncol Lett 8: 1864-1872, 2014.
APA
Cui, C., Shu, C., Yang, Y., Liu, J., Shi, S., Shao, Z. ... Hu, S. (2014). XELIRI compared with FOLFIRI as a second‑line treatment in patients with metastatic colorectal cancer. Oncology Letters, 8, 1864-1872. https://doi.org/10.3892/ol.2014.2335
MLA
Cui, C., Shu, C., Yang, Y., Liu, J., Shi, S., Shao, Z., Wang, N., Yang, T., Hu, S."XELIRI compared with FOLFIRI as a second‑line treatment in patients with metastatic colorectal cancer". Oncology Letters 8.4 (2014): 1864-1872.
Chicago
Cui, C., Shu, C., Yang, Y., Liu, J., Shi, S., Shao, Z., Wang, N., Yang, T., Hu, S."XELIRI compared with FOLFIRI as a second‑line treatment in patients with metastatic colorectal cancer". Oncology Letters 8, no. 4 (2014): 1864-1872. https://doi.org/10.3892/ol.2014.2335
Copy and paste a formatted citation
x
Spandidos Publications style
Cui C, Shu C, Yang Y, Liu J, Shi S, Shao Z, Wang N, Yang T and Hu S: XELIRI compared with FOLFIRI as a second‑line treatment in patients with metastatic colorectal cancer. Oncol Lett 8: 1864-1872, 2014.
APA
Cui, C., Shu, C., Yang, Y., Liu, J., Shi, S., Shao, Z. ... Hu, S. (2014). XELIRI compared with FOLFIRI as a second‑line treatment in patients with metastatic colorectal cancer. Oncology Letters, 8, 1864-1872. https://doi.org/10.3892/ol.2014.2335
MLA
Cui, C., Shu, C., Yang, Y., Liu, J., Shi, S., Shao, Z., Wang, N., Yang, T., Hu, S."XELIRI compared with FOLFIRI as a second‑line treatment in patients with metastatic colorectal cancer". Oncology Letters 8.4 (2014): 1864-1872.
Chicago
Cui, C., Shu, C., Yang, Y., Liu, J., Shi, S., Shao, Z., Wang, N., Yang, T., Hu, S."XELIRI compared with FOLFIRI as a second‑line treatment in patients with metastatic colorectal cancer". Oncology Letters 8, no. 4 (2014): 1864-1872. https://doi.org/10.3892/ol.2014.2335
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