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Article

DNA repair gene XRCC1 Arg194Trp polymorphism and susceptibility to hepatocellular carcinoma: A meta‑analysis

  • Authors:
    • Wenyan Li
    • Feng Yang
    • Yongxian Gui
    • Junjie Bian
  • View Affiliations / Copyright

    Affiliations: Department of Oncology, Xinxiang Central Hospital, Xinxiang Medical College, Xinxiang, Henan 453000, P.R. China, Department of Integrated Medicine, Henan Cancer Hospital, Zhengzhou, Henan 450000, P.R. China
  • Pages: 1725-1730
    |
    Published online on: July 15, 2014
       https://doi.org/10.3892/ol.2014.2351
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Abstract

The arginine194tryptophan (Arg194Trp) polymorphism in the X‑ray repair cross‑complementing group 1 (XRCC1) gene has been reported to be associated with hepatocellular carcinoma (HCC), however, the results from previous studies are conflicting. The present study aimed to investigate the association between the XRCC1 Arg194Trp polymorphism and the risk of HCC, using a meta‑analysis of previously published studies. PubMed (http://www.ncbi.nlm.nih.gov/pubmed/), Google Scholar (http://scholar.google.co.uk/) and the China National Knowledge Infrastructure databases (http://www.cnki.net/) were systematically searched to identify relevant studies published prior to October 2013. A meta‑analysis was performed to examine the association between the Arg194Trp gene polymorphism and the susceptibility to HCC. Odds ratios (ORs) and 95% confidence intervals (95% CIs) were calculated. The meta‑analysis consisted of six case‑control studies that included 1,451 HCC cases and 1,398 healthy controls. Meta‑analysis results based on all the studies showed no significant association between the XRCC1 Arg194Trp gene polymorphism and the risk of HCC (Trp/Trp vs. Arg/Arg: OR, 1.17; 95% CI, 0.89‑1.55; Trp/Trp vs. Arg/Trp: OR, 0.94; 95% CI, 0.59‑1.51; dominant model: OR, 0.97; 95% CI, 0.63‑1.49; recessive model: OR, 1.22; 95% CI, 0.89‑1.67). In the subgroup analysis, three studies with sample sizes of >300 produced similar results that indicated that the Arg194Trp gene polymorphism had no association with an increased or decreased risk of HCC. The pooled ORs were not markedly different following the exclusion of two studies deviating from the Hardy‑Weinberg equilibrium in the control group, which indicated the reliability of the meta‑analysis results. In conclusion, the XRCC1 Arg194Trp polymorphism may not be a risk or protective factor for HCC. Further large and well‑designed studies are required to confirm these results.
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Copy and paste a formatted citation
Spandidos Publications style
Li W, Yang F, Gui Y and Bian J: DNA repair gene XRCC1 Arg194Trp polymorphism and susceptibility to hepatocellular carcinoma: A meta‑analysis. Oncol Lett 8: 1725-1730, 2014.
APA
Li, W., Yang, F., Gui, Y., & Bian, J. (2014). DNA repair gene XRCC1 Arg194Trp polymorphism and susceptibility to hepatocellular carcinoma: A meta‑analysis. Oncology Letters, 8, 1725-1730. https://doi.org/10.3892/ol.2014.2351
MLA
Li, W., Yang, F., Gui, Y., Bian, J."DNA repair gene XRCC1 Arg194Trp polymorphism and susceptibility to hepatocellular carcinoma: A meta‑analysis". Oncology Letters 8.4 (2014): 1725-1730.
Chicago
Li, W., Yang, F., Gui, Y., Bian, J."DNA repair gene XRCC1 Arg194Trp polymorphism and susceptibility to hepatocellular carcinoma: A meta‑analysis". Oncology Letters 8, no. 4 (2014): 1725-1730. https://doi.org/10.3892/ol.2014.2351
Copy and paste a formatted citation
x
Spandidos Publications style
Li W, Yang F, Gui Y and Bian J: DNA repair gene XRCC1 Arg194Trp polymorphism and susceptibility to hepatocellular carcinoma: A meta‑analysis. Oncol Lett 8: 1725-1730, 2014.
APA
Li, W., Yang, F., Gui, Y., & Bian, J. (2014). DNA repair gene XRCC1 Arg194Trp polymorphism and susceptibility to hepatocellular carcinoma: A meta‑analysis. Oncology Letters, 8, 1725-1730. https://doi.org/10.3892/ol.2014.2351
MLA
Li, W., Yang, F., Gui, Y., Bian, J."DNA repair gene XRCC1 Arg194Trp polymorphism and susceptibility to hepatocellular carcinoma: A meta‑analysis". Oncology Letters 8.4 (2014): 1725-1730.
Chicago
Li, W., Yang, F., Gui, Y., Bian, J."DNA repair gene XRCC1 Arg194Trp polymorphism and susceptibility to hepatocellular carcinoma: A meta‑analysis". Oncology Letters 8, no. 4 (2014): 1725-1730. https://doi.org/10.3892/ol.2014.2351
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