Malignant melanoma of the vagina: A case report and review of the literature

Chen,Lifeng; Xiong,Yin; Wang,Huan; Liang,Lizhi; Shang,Huiling; Yan,Xiaojian

doi:10.3892/ol.2014.2357

Malignant melanoma of the vagina: A case report and review of the literature

Authors:
- Lifeng Chen
- Yin Xiong
- Huan Wang
- Lizhi Liang
- Huiling Shang
- Xiaojian Yan
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Affiliations: Department of Gynecology, Zhejiang Provincial People's Hospital, Hangzhou, Zhejiang 310014, P.R. China, Department of Gynecology, Cancer Center, Sun Yat-Sen University, Guangzhou, Guangdong 510060, P.R. China, Department of Gynecology, The Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou, Guangdong 510630, P.R. China, Department of Gynecology, The First People's Hospital of Foshan, Guangzhou, Guangdong 528000, P.R. China, Department of Gynecology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang 325000, P.R. China
Published online on: July 17, 2014 https://doi.org/10.3892/ol.2014.2357
Pages: 1585-1588

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Abstract

Primary malignant melanoma of the vagina is an extremely rare variant of melanoma that accounts for <3% of all vaginal malignancies. Primary malignant melanoma of the vagina has a worse prognosis as compared with non‑genital melanomas or other vaginal malignant neoplasms. A‑35‑year‑old female had a diagnosis of primary malignant melanoma of the vagina. A local excision of the tumor was first performed, followed by a radical excision as a further therapeutic measure. The patient returned after three weeks, presenting with a vesico‑vaginal fistula. A conservative operation was subsequently performed in order to improve the quality of life of the patient. Pelvic metastases were identified 6 months after the completion of the last surgical therapy and subsequent follow‑up examinations were performed in another hospital. The present case study describes the clinical features and surgical procedures of this patient with primary malignant melanoma of the vagina. In conclusion, melanoma of the vagina is an extremely aggressive cancer and the overall prognosis is poor despite the various treatment options.

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1	Hu DN, Yu GP and McCormick SA: Population-based incidence of vulvar and vaginal melanoma in various races and ethnic groups with comparisons to other site-specific melanomas. Melanoma Res. 20:153–158. 2010.
2	Irvin WP Jr, Bliss SA, Rice LW, Taylor PT Jr and Andersen WA: Malignant melanoma of the vagina and locoregional control: radical surgery revisited. Gynecol Oncol. 71:476–480. 1998.
3	Gupta D, Malpica A, Deavers MT and Silva EG: Vaginal melanoma: a clinicopathologic and immunohistochemical study of 26 cases. Am J Surg Pathol. 26:1450–1457. 2002.
4	Miner TJ, Delgado R, Zeisler J, et al: Primary vaginal melanoma: a critical analysis of therapy. Ann Surg Oncol. 11:34–39. 2004.
5	Staiano JJ, Wong L, Butler J, et al: Flap reconstruction following gynaecological tumor resection for advanced and recurrent disease - a 12 year experience. J Plast Reconstr Aesthet Surg. 62:346–351. 2009.
6	Oguri H, Izumiya C, Maeda N, Fukaya T and Moriki T: A primary amelanotic melanoma of the vagina, diagnosed by immunohistochemical staining with HMB-45, which recurred as a pigmented melanoma. J Clin Pathol. 57:986–988. 2004.
7	Grenader T, Isacson R, Reinus C, et al: Primary amelanotic melanoma of the vagina. Onkologie. 31:474–476. 2008.
8	Buchanan DJ, Schlaerth J and Kurosaki T: Primary vaginal melanoma: thirteen-year disease-free survival after wide local excision and review of recent literature. Am J Obstet Gynecol. 178:1177–1184. 1998.
9	Ariel IM: Malignant melanoma of the female genital system: a report of 48 patients and review of the literature. J Surg Oncol. 16:371–383. 1981.
10	Van Nostrand KM, Lucci JA 3rd, Schell M, et al: Primary vaginal melanoma: improved survival with radical pelvic surgery. Gynecol Oncol. 55:234–237. 1994.
11	Petru E, Nagele F, Czerwenka K, et al: Primary malignant melanoma of the vagina: long-term remission following radiation therapy. Gynecol Oncol. 70:23–26. 1998.
12	Rodier JF, Janser JC, David E, Routiot T and Ott G: Radiopharmaceutical-guided surgery in primary malignant melanoma of the vagina. Gynecol Oncol. 75:308–309. 1999.
13	Ragnarsson-Olding B, Johansson H, Rutqvist LE and Ringborg U: Malignant melanoma of the vulva and vagina. Trends in incidence, age distribution, and long-term survival among 245 consecutive cases in Sweden 1960–1984. Cancer. 71:1893–1897. 1993.
14	Frumovitz M, Etchepareborda M, Sun CC, et al: Primary malignant melanoma of the vagina. Obstetrics and Gynecology. 116:1358–1365. 2010.
15	Greggi S, Losito S, Pisano C, Desicato S and Scaffa C: Malignant melanoma of the vagina: report of two cases and review of the literature. Int Surg. 95:120–125. 2010.
16	Li Y, Li M and Wu Q: Clinical analysis of 25 cases of primary vaginal malignant melanoma. Zhonghua Fu Chan Ke Za Zhi. 34:162–164. 1999.(In Chinese).
17	Baloglu A, Bezircioglu I, Cetinkaya B and Yavuzcan A: Primary malignant melanoma of the vagina. Arch Gynecol Obstet. 280:819–822. 2009.
18	Liu L, Li X and Hong W: Primary malignant melanoma of the vagina: a report of 22 cases. Zhonghua Zhong Liu Za Zhi. 18:385–387. 1996.(In Chinese).
19	Skowronek J and Roszak A: A case of metastatic malignant melanoma of the vagina with a background of primary vaginal melanoma - clinical case. Ginekol Pol. 68:390–393. 1997.(In Polish).
20	Räber G, Mempel V, Jackisch C and Schneider HP: Clinical aspects of primary malignant melanoma of the vagina. Zentralbl Gynakol. 115:416–422. 1993.(In German).
21	Geisler JP, Look KY, Moore DA and Sutton GP: Pelvic exenteration for malignant melanomas of the vagina or urethra with over 3 mm of invasion. Gynecol Oncol. 59:338–341. 1995.
22	Gökaslan H, Sismanoğlu A, Pekin T, Kaya H and Ceyhan N: Primary malignant melanoma of the vagina: a case report and review of the current treatment options. Eur J Obstet Gynecol Reprod Bio. 121:243–248. 2005.
23	DeMatos P, Tyler D and Seigler HF: Mucosal melanoma of the female genitalia: a clinicopathologic study of forty-three cases at Duke University Medical Center. Surgery. 124:38–48. 1998.
24	Coleman RL: Primary vaginal melanoma: a rare and problematic clinical entity. Ann Surg Oncol. 11:4–6. 2004.
25	Nakagawa S, Koga K, Kugu K, Tsutsumi O and Taketani Y: The evaluation of the sentinel node successfully conducted in a case of malignant melanoma of the vagina. Gynecol Oncol. 86:387–389. 2002.
26	Siu SS, Lo KW, Chan AB, Yu MY and Cheung TH: Nodal detection in malignant melanoma of the vagina using laparoscopic ultrasonography. Gynecol Oncol. 92:985–988. 2004.
27	Newlin HE, Morris CG, Amdur RJ and Mendenhall WM: Neurotropic melanoma of the head and neck with clinical perineural invasion. Am J Clin Oncol. 28:399–402. 2005.
28	Beg MH, Muchmore JH, Carter RD and Krementz ET: Vaginal melanoma and the role of regional chemotherapy. J Surg Oncol. 53:133–135. 1993.
29	Harting MS and Kim KB: Biochemotherapy in patients with advanced vulvovaginal mucosal melanoma. Melanoma Res. 14:517–520. 2004.
30	Eisen T, Ahmad T, Flaherty KT, et al: Sorafenib in advanced melanoma: a Phase II randomised discontinuation trial analysis. Br J Cancer. 95:581–586. 2006.