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Print ISSN: 1792-1074 Online ISSN: 1792-1082
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October 2014 Volume 8 Issue 4

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Article

Synergistic antitumor effects of combined deguelin and cisplatin treatment in gastric cancer cells

  • Authors:
    • Zhengguang Li
    • Changping Wu
    • Jun Wu
    • Mei Ji
    • Liangrong  Shi
    • Jingting Jiang
    • Bin Xu
    • Jinjin Yuan
  • View Affiliations / Copyright

    Affiliations: Department of Oncology, The Third Affiliated Hospital of Soochow University, Changzhou, Jiangsu 213003, P.R. China
  • Pages: 1603-1607
    |
    Published online on: July 22, 2014
       https://doi.org/10.3892/ol.2014.2368
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Abstract

Deguelin is a naturally occurring rotenoid with marked chemopreventive and antitumor activity. Cisplatin, characterized by damaging DNA, is widely used in the chemotherapy of malignancies, including gastric cancer. The present study investigated whether synergistic effects exist between the combination of deguelin and cisplatin, and the possible mechanism in vitro. The interactive effects of deguelin in combination with various concentrations of cisplatin were evaluated in the human gastric cancer MGC‑803 cell line. The inhibition of cell proliferation was determined by 3‑(4,5)‑dimethylthiazol(‑2‑yl)‑2,5‑diphenyltetrazolium bromide assay and the mechanisms underlying the effects were further evaluated by western blot analysis. The results revealed that the combined treatment of deguelin and cisplatin exhibited a marked inhibition of MGC‑803 cell proliferation when compared with that of the single therapies in vitro. In addition, isobologram analysis revealed that this combined treatment showed a synergistic effect. These observations may have promising therapeutic value for gastric cancer and thus warrant further investigation.
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Copy and paste a formatted citation
Spandidos Publications style
Li Z, Wu C, Wu J, Ji M, Shi L, Jiang J, Xu B and Yuan J: Synergistic antitumor effects of combined deguelin and cisplatin treatment in gastric cancer cells. Oncol Lett 8: 1603-1607, 2014.
APA
Li, Z., Wu, C., Wu, J., Ji, M., Shi, L., Jiang, J. ... Yuan, J. (2014). Synergistic antitumor effects of combined deguelin and cisplatin treatment in gastric cancer cells. Oncology Letters, 8, 1603-1607. https://doi.org/10.3892/ol.2014.2368
MLA
Li, Z., Wu, C., Wu, J., Ji, M., Shi, L., Jiang, J., Xu, B., Yuan, J."Synergistic antitumor effects of combined deguelin and cisplatin treatment in gastric cancer cells". Oncology Letters 8.4 (2014): 1603-1607.
Chicago
Li, Z., Wu, C., Wu, J., Ji, M., Shi, L., Jiang, J., Xu, B., Yuan, J."Synergistic antitumor effects of combined deguelin and cisplatin treatment in gastric cancer cells". Oncology Letters 8, no. 4 (2014): 1603-1607. https://doi.org/10.3892/ol.2014.2368
Copy and paste a formatted citation
x
Spandidos Publications style
Li Z, Wu C, Wu J, Ji M, Shi L, Jiang J, Xu B and Yuan J: Synergistic antitumor effects of combined deguelin and cisplatin treatment in gastric cancer cells. Oncol Lett 8: 1603-1607, 2014.
APA
Li, Z., Wu, C., Wu, J., Ji, M., Shi, L., Jiang, J. ... Yuan, J. (2014). Synergistic antitumor effects of combined deguelin and cisplatin treatment in gastric cancer cells. Oncology Letters, 8, 1603-1607. https://doi.org/10.3892/ol.2014.2368
MLA
Li, Z., Wu, C., Wu, J., Ji, M., Shi, L., Jiang, J., Xu, B., Yuan, J."Synergistic antitumor effects of combined deguelin and cisplatin treatment in gastric cancer cells". Oncology Letters 8.4 (2014): 1603-1607.
Chicago
Li, Z., Wu, C., Wu, J., Ji, M., Shi, L., Jiang, J., Xu, B., Yuan, J."Synergistic antitumor effects of combined deguelin and cisplatin treatment in gastric cancer cells". Oncology Letters 8, no. 4 (2014): 1603-1607. https://doi.org/10.3892/ol.2014.2368
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