Immune reconstitution from peripheral blood mononuclear cells inhibits lung carcinoma growth in NOD/SCID mice

  • Authors:
    • Xiang Liu
    • Huiling Li
    • Jun Liu
    • Yubao Guan
    • Liyan Huang
    • Hailing Tang
    • Jianxing He
  • View Affiliations

  • Published online on: July 24, 2014     https://doi.org/10.3892/ol.2014.2379
  • Pages: 1638-1644
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Abstract

Drug resistance and immune deficiency are important factors for the poor prognosis of lung carcinoma. The present study explored the possible protective effect of immune reconstitution from peripheral blood mononuclear cells (PBMCs) on multi‑drug‑resistant human lung carcinoma Am1010 cells in non‑obese diabetic/severe combined immunodeficient (NOD/SCID) mice. The inoculated tumor fragments grew rapidly in the NOD/SCID mice. The growth was significantly inhibited by intraperitoneal injection of PBMCs. In the mice injected with PBMCs, numerous CD3+ and CD8+ cells, but less CD4+ cells, were found in spleen and tumor tissues. These data suggest that PBMC transplantation inhibits lung carcinoma progression via the reconstitution of the immune system, particularly of cytotoxic T lymphocytes.
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October 2014
Volume 8 Issue 4

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Spandidos Publications style
Liu X, Li H, Liu J, Guan Y, Huang L, Tang H and He J: Immune reconstitution from peripheral blood mononuclear cells inhibits lung carcinoma growth in NOD/SCID mice. Oncol Lett 8: 1638-1644, 2014.
APA
Liu, X., Li, H., Liu, J., Guan, Y., Huang, L., Tang, H., & He, J. (2014). Immune reconstitution from peripheral blood mononuclear cells inhibits lung carcinoma growth in NOD/SCID mice. Oncology Letters, 8, 1638-1644. https://doi.org/10.3892/ol.2014.2379
MLA
Liu, X., Li, H., Liu, J., Guan, Y., Huang, L., Tang, H., He, J."Immune reconstitution from peripheral blood mononuclear cells inhibits lung carcinoma growth in NOD/SCID mice". Oncology Letters 8.4 (2014): 1638-1644.
Chicago
Liu, X., Li, H., Liu, J., Guan, Y., Huang, L., Tang, H., He, J."Immune reconstitution from peripheral blood mononuclear cells inhibits lung carcinoma growth in NOD/SCID mice". Oncology Letters 8, no. 4 (2014): 1638-1644. https://doi.org/10.3892/ol.2014.2379