Squamous cell carcinoma of the uterine cervix associated with osteoclast‑like giant cells: A case report and review of the literature

Yu,Guohua; Lin,Chunhua; Wang,Wei; Han,Yekun; Qu,Guimei; Zhang,Tingguo

doi:10.3892/ol.2014.2384

October 2014 Volume 8 Issue 4

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October 2014 Volume 8 Issue 4

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Case Report

Squamous cell carcinoma of the uterine cervix associated with osteoclast‑like giant cells: A case report and review of the literature

Authors:
- Guohua Yu
- Chunhua Lin
- Wei Wang
- Yekun Han
- Guimei Qu
- Tingguo Zhang
View Affiliations / Copyright

Affiliations: Department of Pathology, Shandong University School of Medicine, Jinan, Shandong 250012, P.R. China, Department of Surgery, Affiliated Yantai Yuhuangding Hospital, Medical College of Qingdao University, Yantai, Shangdong 264000, P.R. China, Department of Pathology, Affiliated Yantai Yuhuangding Hospital, Medical College of Qingdao University, Yantai, Shangdong 264000, P.R. China, Department of Pharmacology, Affiliated Hospital, Binzhou Medical College, Binzhou, Shandong 256603, P.R. China
Pages: 1595-1598
|
Published online on: July 25, 2014

https://doi.org/10.3892/ol.2014.2384
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Abstract

Squamous cell carcinoma is a common malignant tumor of the uterine cervix. The present study reports the case of squamous cell carcinoma of the uterine cervix with osteoclast‑like giant cells (OGCs) in an 84‑year‑old female who had suffered from irregular vaginal bleeding for one month. Colposcopy was performed and a cauliflower‑like mass was identified in the front lip of the uterine cervix. Biopsy was then performed, and the tumor was found to be composed of epithelial cell nests, ranging in size. The neoplastic cells exhibited unclear boundaries and eosinophilic cytoplasm. Additionally, the nuclei were atypical and mitosis was observed. Among the epithelial nests, there were numerous OGCs with abundant eosinophilic cytoplasm, as well as multinucleation with bland nuclei. By immunohistochemical staining, the epithelial cells were positive for cytokeratin, while negative for CD68 and vimentin. By contrast, the immunophenotype of the OGCs was the exact opposite. Based on the histological characters, a diagnosis of squamous cell carcinoma of the uterine cervix associated with OGCs was made. Considering the age of the patient, radiotherapy was administered. The patient succumbed to brain metastasis of the tumor after eight months of follow‑up.

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Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Squamous cell carcinoma of the uterine cervix associated with osteoclast‑like giant cells: A case report and review of the literature

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Abstract

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