Choroidal metastasis as the presenting feature of a non‑small cell lung carcinoma with no apparent primary lesion identified by X‑ray: A case report

Lam,Michael; Lee,Jason; Teoh,Stephen; Agrawal,Rupesh

doi:10.3892/ol.2014.2389

October 2014 Volume 8 Issue 4

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October 2014 Volume 8 Issue 4

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Case Report

Choroidal metastasis as the presenting feature of a non‑small cell lung carcinoma with no apparent primary lesion identified by X‑ray: A case report

Authors:
- Michael Lam
- Jason Lee
- Stephen Teoh
- Rupesh Agrawal
View Affiliations / Copyright

Affiliations: Department of Ophthalmology, National Healthcare Group Eye Institute, Tan Tock Seng Hospital, Singapore 308433, Republic of Singapore
Pages: 1886-1888
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Published online on: July 28, 2014

https://doi.org/10.3892/ol.2014.2389
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Abstract

The most common type of intraocular tumor in adults is the metastatic variety, with the choroid as the typical site of involvement. The case of a patient with non‑small cell lung cancer, who presented with choroidal metastasis, is described in the current report. In addition, the limitation of using a chest X‑ray to identify a large primary lung lesion is highlighted. A 71‑year‑old female that presented with a choroidal mass lesion is described in the current report. A chest X‑ray was conducted and was considered to be normal following detailed investigation, however, a computed tomography (CT) scan of the thorax revealed a large lobulated mass in the right upper lobe. On further histopathological analysis, the patient was diagnosed with a non‑small cell lung carcinoma. Thus, when a large choroidal lesion and overlying exudative retinal detachment is observed, a diagnosis of choroidal metastasis should be considered. X‑ray images may appear to be normal even in the presence of a large pulmonary lesion. Therefore, in cases where there may be a metastatic lesion, a CT scan is proposed as the optimal diagnostic imaging technique.

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1	Ferry AP and Font RL: Carcinoma metastatic to eye and orbit. I A clinicopathologic study of 227 cases. Arch Ophthalmol. 92:276–286. 1974.
2	Stephens RF and Shields JA: Diagnosis and management of cancer metastatic to the uvea: a study of 70 cases. Ophthalmology. 86:1336–1349. 1979.
3	Shields CL, Shields JA, Gross NE, et al: Survey of 520 eyes with uveal metastases. Ophthalmology. 104:1265–1276. 1997.
4	Kreusel KM, Bechrakis N, Wiegel T, et al: Clinical characteristics of choroidal metastasis. Ophthalmologe. 100:618–622. 2003.(In German).
5	Kreusel KM, Wiegel T, Stange M, et al: Choroidal metastasis in disseminated lung cancer: frequency and risk factors. Am J Ophthalmol. 134:445–447. 2002.
6	Kreusel KM, Bornfeld N, Hosten N, Wiegel T and Foerster MH: Solitary choroidal metastasis as the first sign of metastatic lung carcinoid. Arch Ophthalmol. 116:1396–1397. 1998.
7	Simsek T, Ozdamar Y and Berker N: Choroidal mass as an initial presentation of lung cancer. Med Oncol. 25:400–402. 2008.
8	Fernandes BF, Fernandes LH and Burnier MN Jr: Choroidal mass as the presenting sign of small cell lung carcinoma. Can J Ophthalmol. 41:605–608. 2006.
9	Ascaso FJ, Castillo JM, García FJ, Cristóbal JA, Fuertes A and Artal A: Bilateral choroidal metastases revealing an advanced non-small cell lung cancer. Ann Thorac Surg. 88:1013–1015. 2009.
10	Koçak Z, Tabakoğlu E, Benian O, Bayir G, Unlü E and Uzal C: Bilateral choroidal metastases as an initial manifestation of small-cell carcinoma of the lung. Tuberk Toraks. 54:61–64. 2006.

Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Choroidal metastasis as the presenting feature of a non‑small cell lung carcinoma with no apparent primary lesion identified by X‑ray: A case report

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