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Article

Controlling serum uric acid using febuxostat in cancer patients at risk of tumor lysis syndrome

  • Authors:
    • Mihoko Takai
    • Takahiro Yamauchi
    • Kei Fujita
    • Shin Lee
    • Miyuki Ookura
    • Shinji Kishi
    • Yoshimasa Urasaki
    • Akira Yoshida
    • Hiromichi Iwasaki
    • Takanori Ueda
  • View Affiliations / Copyright

    Affiliations: Department of Hematology and Oncology, University of Fukui, Matsuoka, Eiheiji, Fukui 910‑1193, Japan, Division of Infection Control, University of Fukui, Matsuoka, Eiheiji, Fukui 910‑1193, Japan
  • Pages: 1523-1527
    |
    Published online on: July 30, 2014
       https://doi.org/10.3892/ol.2014.2394
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Abstract

Tumor lysis syndrome (TLS) is a life‑threatening oncological emergency, in which control of serum uric acid (S‑UA) levels is important. S‑UA‑lowering efficacy of a new xanthine oxidase inhibitor, febuxostat, was retrospectively evaluated in seven patients with hematological malignancies who were at an intermediate risk of developing TLS. A 10‑mg dose of febuxostat was initiated and chemotherapy was started within 24 h of administering the first dose of febuxostat. Febuxostat was continued until at least day 7 of chemotherapy treatment. The UA‑lowering treatment was considered effective if febuxostat reduced S‑UA levels to ≤7.5 mg/dl by day 5. The mean S‑UA level at base line was 6.4±2.6 mg/dl and, on day 5, the mean S‑UA level was 4.7±1.8 mg/dl. All the patients achieved S‑UA levels ≤7.5 mg/dl. Serum creatinine levels decreased from 0.93±0.25 to 0.85±0.25 mg/dl. The estimated glomerular filtration rate values increased from 69.7±24.5 to 76.9±26.2 ml/min. No adverse reactions were noted during the study period and no patients experienced progressive TLS. Successful control of S‑UA and improved renal function were obtained in response to febuxostat treatment in cancer patients at a risk of TLS.
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Copy and paste a formatted citation
Spandidos Publications style
Takai M, Yamauchi T, Fujita K, Lee S, Ookura M, Kishi S, Urasaki Y, Yoshida A, Iwasaki H, Ueda T, Ueda T, et al: Controlling serum uric acid using febuxostat in cancer patients at risk of tumor lysis syndrome. Oncol Lett 8: 1523-1527, 2014.
APA
Takai, M., Yamauchi, T., Fujita, K., Lee, S., Ookura, M., Kishi, S. ... Ueda, T. (2014). Controlling serum uric acid using febuxostat in cancer patients at risk of tumor lysis syndrome. Oncology Letters, 8, 1523-1527. https://doi.org/10.3892/ol.2014.2394
MLA
Takai, M., Yamauchi, T., Fujita, K., Lee, S., Ookura, M., Kishi, S., Urasaki, Y., Yoshida, A., Iwasaki, H., Ueda, T."Controlling serum uric acid using febuxostat in cancer patients at risk of tumor lysis syndrome". Oncology Letters 8.4 (2014): 1523-1527.
Chicago
Takai, M., Yamauchi, T., Fujita, K., Lee, S., Ookura, M., Kishi, S., Urasaki, Y., Yoshida, A., Iwasaki, H., Ueda, T."Controlling serum uric acid using febuxostat in cancer patients at risk of tumor lysis syndrome". Oncology Letters 8, no. 4 (2014): 1523-1527. https://doi.org/10.3892/ol.2014.2394
Copy and paste a formatted citation
x
Spandidos Publications style
Takai M, Yamauchi T, Fujita K, Lee S, Ookura M, Kishi S, Urasaki Y, Yoshida A, Iwasaki H, Ueda T, Ueda T, et al: Controlling serum uric acid using febuxostat in cancer patients at risk of tumor lysis syndrome. Oncol Lett 8: 1523-1527, 2014.
APA
Takai, M., Yamauchi, T., Fujita, K., Lee, S., Ookura, M., Kishi, S. ... Ueda, T. (2014). Controlling serum uric acid using febuxostat in cancer patients at risk of tumor lysis syndrome. Oncology Letters, 8, 1523-1527. https://doi.org/10.3892/ol.2014.2394
MLA
Takai, M., Yamauchi, T., Fujita, K., Lee, S., Ookura, M., Kishi, S., Urasaki, Y., Yoshida, A., Iwasaki, H., Ueda, T."Controlling serum uric acid using febuxostat in cancer patients at risk of tumor lysis syndrome". Oncology Letters 8.4 (2014): 1523-1527.
Chicago
Takai, M., Yamauchi, T., Fujita, K., Lee, S., Ookura, M., Kishi, S., Urasaki, Y., Yoshida, A., Iwasaki, H., Ueda, T."Controlling serum uric acid using febuxostat in cancer patients at risk of tumor lysis syndrome". Oncology Letters 8, no. 4 (2014): 1523-1527. https://doi.org/10.3892/ol.2014.2394
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