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Article

Increased frequency of Mediterranean fever gene variants in multiple myeloma

  • Authors:
    • Serkan Celik
    • Fatih Tangi
    • Cagatay Oktenli
  • View Affiliations / Copyright

    Affiliations: Division of Oncology, GATA Haydarpasa Training Hospital, Istanbul, Turkey, Division of Internal Medicine, GATA Haydarpasa Training Hospital, Istanbul, Turkey, Department of Internal Medicine, Anadolu Medical Center, Kocaeli, Turkey
  • Pages: 1735-1738
    |
    Published online on: August 4, 2014
       https://doi.org/10.3892/ol.2014.2407
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Abstract

High frequencies of inherited variants in the Mediterranean fever (MEFV) gene have been identified in patients with multiple myeloma (MM). The sample size of the present pilot study was small, therefore, the actual frequency of inherited variants in the MEFV gene could be investigated in patients with MM. Twenty‑eight patients with MM and 65 healthy controls were included in the study. Six heterozygous and one homozygous (E148Q/E148Q) variant was identified in patients with MM. None of the patients had a family history compatible with familial Mediterranean fever. In the healthy control group, 11 heterozygous variants were identified. The difference in the overall frequency of the inherited variants in the MEFV gene between the MM patients and the controls was statistically significant (χ2=4.905; P=0.027). In conclusion, a high frequency of inherited variants in the MEFV gene was identified in patients with MM. Based on the current data, it is hypothesized that the MEFV gene is a cancer susceptibility gene. Additional evidence, such as familial aggregation, monozygotic versus dizygotic twin concordance, and tumors in genetically engineered model organisms, is required in order to support this hypothesis.
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Copy and paste a formatted citation
Spandidos Publications style
Celik S, Tangi F and Oktenli C: Increased frequency of Mediterranean fever gene variants in multiple myeloma. Oncol Lett 8: 1735-1738, 2014.
APA
Celik, S., Tangi, F., & Oktenli, C. (2014). Increased frequency of Mediterranean fever gene variants in multiple myeloma. Oncology Letters, 8, 1735-1738. https://doi.org/10.3892/ol.2014.2407
MLA
Celik, S., Tangi, F., Oktenli, C."Increased frequency of Mediterranean fever gene variants in multiple myeloma". Oncology Letters 8.4 (2014): 1735-1738.
Chicago
Celik, S., Tangi, F., Oktenli, C."Increased frequency of Mediterranean fever gene variants in multiple myeloma". Oncology Letters 8, no. 4 (2014): 1735-1738. https://doi.org/10.3892/ol.2014.2407
Copy and paste a formatted citation
x
Spandidos Publications style
Celik S, Tangi F and Oktenli C: Increased frequency of Mediterranean fever gene variants in multiple myeloma. Oncol Lett 8: 1735-1738, 2014.
APA
Celik, S., Tangi, F., & Oktenli, C. (2014). Increased frequency of Mediterranean fever gene variants in multiple myeloma. Oncology Letters, 8, 1735-1738. https://doi.org/10.3892/ol.2014.2407
MLA
Celik, S., Tangi, F., Oktenli, C."Increased frequency of Mediterranean fever gene variants in multiple myeloma". Oncology Letters 8.4 (2014): 1735-1738.
Chicago
Celik, S., Tangi, F., Oktenli, C."Increased frequency of Mediterranean fever gene variants in multiple myeloma". Oncology Letters 8, no. 4 (2014): 1735-1738. https://doi.org/10.3892/ol.2014.2407
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