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Print ISSN: 1792-1074 Online ISSN: 1792-1082
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December-2014 Volume 8 Issue 6

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International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

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International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

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Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

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Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

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Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

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Case Report

Malignant gastrointestinal neuroectodermal tumor: A case report and review of the literature

  • Authors:
    • Jie Kong
    • Nan Li
    • Shiwu Wu
    • Xingmei Guo
    • Congyou Gu
    • Zhenzhong Feng
  • View Affiliations / Copyright

    Affiliations: Department of Pathology, The First Affiliated Hospital of Bengbu Medical College, Bengbu Medical College, Bengbu, Anhui 233000, P.R. China
  • Pages: 2687-2690
    |
    Published online on: September 11, 2014
       https://doi.org/10.3892/ol.2014.2524
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Abstract

Malignant gastrointestinal neuroectodermal tumor (GNET) is a rare soft tissue sarcoma, previously referred to as clear cell sarcoma‑like gastrointestinal tumor (CCSLGT) and also commonly reported in the literature as clear cell sarcoma of the gastrointestinal tract (CCS‑GI). The current study reports a case of GNET arising in the stomach of a 17‑year‑old male, who presented with symptoms of fatigue, anemia and low temperature. Examination with positron emission tomography‑computed tomography revealed a soft tissue mass in the gastric antrum. Subsequently, radical distal gastric resection was performed, and the mass measured 6.0x4.0x3.5 cm3. Histopathological analysis revealed that the tumor cells were arranged in nests and focally formed fascicular, pseudopapillary, pseudoalveolar and rosette‑like growth patterns. Osteoclast‑like giant cells were also observed. Immunohistochemically, the tumor cells were positive for S‑100 protein, vimentin and BCL‑2, and negative for HMB45, Melan‑A, CD117, CD34 and CD99. Additionally, the osteoclast‑like giant cells were positive for CD68. Fluorescence in situ hybridization demonstrated EWSR1 gene rearrangement. After 10 months of follow‑up, no evidence of recurrence or metastasis was observed. As GNET is currently classified differently and under various names in the literature, the information provided by this case study and review is predicted to be useful towards the accurate diagnosis, treatment and prognosis of this rare tumor type.
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Copy and paste a formatted citation
Spandidos Publications style
Kong J, Li N, Wu S, Guo X, Gu C and Feng Z: Malignant gastrointestinal neuroectodermal tumor: A case report and review of the literature. Oncol Lett 8: 2687-2690, 2014.
APA
Kong, J., Li, N., Wu, S., Guo, X., Gu, C., & Feng, Z. (2014). Malignant gastrointestinal neuroectodermal tumor: A case report and review of the literature. Oncology Letters, 8, 2687-2690. https://doi.org/10.3892/ol.2014.2524
MLA
Kong, J., Li, N., Wu, S., Guo, X., Gu, C., Feng, Z."Malignant gastrointestinal neuroectodermal tumor: A case report and review of the literature". Oncology Letters 8.6 (2014): 2687-2690.
Chicago
Kong, J., Li, N., Wu, S., Guo, X., Gu, C., Feng, Z."Malignant gastrointestinal neuroectodermal tumor: A case report and review of the literature". Oncology Letters 8, no. 6 (2014): 2687-2690. https://doi.org/10.3892/ol.2014.2524
Copy and paste a formatted citation
x
Spandidos Publications style
Kong J, Li N, Wu S, Guo X, Gu C and Feng Z: Malignant gastrointestinal neuroectodermal tumor: A case report and review of the literature. Oncol Lett 8: 2687-2690, 2014.
APA
Kong, J., Li, N., Wu, S., Guo, X., Gu, C., & Feng, Z. (2014). Malignant gastrointestinal neuroectodermal tumor: A case report and review of the literature. Oncology Letters, 8, 2687-2690. https://doi.org/10.3892/ol.2014.2524
MLA
Kong, J., Li, N., Wu, S., Guo, X., Gu, C., Feng, Z."Malignant gastrointestinal neuroectodermal tumor: A case report and review of the literature". Oncology Letters 8.6 (2014): 2687-2690.
Chicago
Kong, J., Li, N., Wu, S., Guo, X., Gu, C., Feng, Z."Malignant gastrointestinal neuroectodermal tumor: A case report and review of the literature". Oncology Letters 8, no. 6 (2014): 2687-2690. https://doi.org/10.3892/ol.2014.2524
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