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Clinical significance of migration and invasion inhibitor protein expression in non-small‑cell lung cancer

  • Authors:
    • Xinhua Wang
    • Hongling Liu
    • Xiaoyu Wang
    • Yuzhi An
  • View Affiliations / Copyright

    Affiliations: Department of Oncology, The First Affiliated Hospital of Liaoning Medical University, Jinzhou, Liaoning 121000, P.R. China, Department of Respiratory Internal Medicine, Qingzhou People's Hospital, Qinzhou, Shandong 262500, P.R. China
  • Pages: 2417-2422
    |
    Published online on: September 12, 2014
       https://doi.org/10.3892/ol.2014.2526
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Abstract

Migration and invasion inhibitor protein (MIIP) was initially identified in a yeast two‑hybrid screen. Recently, MIIP has emerged as a key protein in regulating cell migration and invasion. However, the MIIP expression profile in non‑small‑cell lung cancer (NSCLC) has not been analyzed. In the present study, MIIP mRNA expression levels were evaluated using the SYBR Green quantitative real‑time polymerase chain reaction method in 37 NSCLC specimens and matched normal tissue samples. MIIP protein expression in a further 94 NSCLC specimens was examined with immunohistochemistry. Patient survival data were collected retrospectively, and the association between MIIP protein expression and the five‑year overall survival rate was evaluated. The results revealed that MIIP mRNA and protein expression were downregulated in cancer tissues, as compared with the matched normal tissues. MIIP expression levels were significantly associated with pathology and tumor stage, with reduced MIIP mRNA expression levels detected in advanced tumor stage samples. Furthermore, patients with MIIP‑positive protein expression had an improved prognosis as compared with those patients with MIIP‑negative protein expression, with five‑year survival rates of 41.7 and 22.4%, respectively (Kaplan‑Meier, log‑rank, P=0.028). A significant association between MIIP protein expression and improved prognosis was also demonstrated using univariate and multivariate analyses (P=0.033 and P=0.040, respectively). These results suggest that MIIP may have a potential role in the pathogenesis of NSCLC and also confirm that MIIP is a putative tumor‑suppressor gene. Therefore, MIIP may be identified as a functional genetic marker of NSCLC development and prognosis, and may be an attractive therapeutic target for the treatment of lung cancer.
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1 

Jemal A, Bray F, Center MM, et al: Global cancer statistics. CA Cancer J Clin. 61:69–90. 2011.

2 

Yang L, Parkin DM, Ferlay J, Li L and Chen Y: Estimates of cancer incidence in China for 2000 and projections for 2005. Cancer Epidemiol Biomarkers Prev. 14:243–250. 2005.

3 

Esposito L, Conti D, Ailavajhala R, Khalil N and Giordano A: Lung Cancer: Are we up to the Challenge? Curr Genomics. 11:513–518. 2010.

4 

Alberg AJ, Ford JG and Samet JM; American College of Chest Physicians. Epidemiology of lung cancer: ACCP evidence-based clinical practice guidelines (2nd edition). Chest. 132(3 Suppl): 29S–55S. 2007.

5 

Song SW, Fuller GN, Zheng H and Zhang W: Inactivation of the invasion inhibitory gene IIp45 by alternative splicing in gliomas. Cancer Res. 65:3562–3567. 2005.

6 

Song SW, Fuller GN, Khan A, et al: IIp45, an insulin-like growth factor binding protein 2 (IGFBP-2) binding protein, antagonizes IGFBP-2 stimulation of glioma cell invasion. Proc Natl Acad Sci USA. 100:13970–13975. 2003.

7 

Wang Y, Wen J and Zhang W: MIIP, a cytoskeleton regulator that blocks cell migration and invasion, delays mitosis, and suppresses tumorogenesis. Curr Protein Pept Sci. 12:68–73. 2011.

8 

Munirajan AK, Ando K, Mukai A, et al: KIF1Bbeta functions as a haploinsufficient tumor suppressor gene mapped to chromosome 1p36.2 by inducing apoptotic cell death. J Biol Chem. 283:24426–24434. 2008.

9 

Fujita T, Igarashi J, Okawa ER, et al: CHD5, a tumor suppressor gene deleted from 1p36.31 in neuroblastomas. J Natl Cancer Inst. 100:940–949. 2008.

10 

Ragnarsson G, Eiriksdottir G, Johannsdottir JT, et al: Loss of heterozygosity at chromosome 1p in different solid human tumours: association with survival. Br J Cancer. 79:1468–1474. 1999.

11 

Gibbs M, Stanford JL, McIndoe RA, et al: Evidence for a rare prostate cancer-susceptibility locus at chromosome 1p36. Am J Hum Genet. 64:776–787. 1999.

12 

Yanada M, Yaoi T, Shimada J, et al: Frequent hemizygous deletion at 1p36 and hypermethylation downregulate RUNX3 expression in human lung cancer cell lines. Oncol Rep. 14:817–822. 2005.

13 

Ji P, Smith SM, Wang Y, et al: Inhibition of gliomagenesis and attenuation of mitotic transition by MIIP. Oncogene. 29:3501–3508. 2010.

14 

Shimosato Y: Histological Typing of Lung and Pleural Tumors (3rd edition, 1999): Malignant epithelial tumors. Nihon Rinsho. 60(Suppl 5): 123–131. 2002.(In Japanese).

15 

Detterbeck FC, Boffa DJ and Tanoue LT: The new lung cancer staging system. Chest. 136:260–271. 2009.

16 

Cunha-Ferreira I, Bento I and Bettencourt-Dias M: From zero to many: control of centriole number in development and disease. Traffic. 10:482–498. 2009.

17 

Mehlen P and Puisieux A: Metastasis: a question of life or death. Nat Rev Cancer. 6:449–458. 2006.

18 

Wu Y, Song SW, Sun J, et al: IIp45 inhibits cell migration through inhibition of HDAC6. J Biol Chem. 285:3554–3560. 2010.

19 

Song F, Ji P, Zheng H, et al: Definition of a functional single nucleotide polymorphism in the cell migration inhibitory gene MIIP that affects the risk of breast cancer. Cancer Res. 70:1024–1032. 2010.

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Copy and paste a formatted citation
Spandidos Publications style
Wang X, Liu H, Wang X and An Y: Clinical significance of migration and invasion inhibitor protein expression in non-small‑cell lung cancer. Oncol Lett 8: 2417-2422, 2014.
APA
Wang, X., Liu, H., Wang, X., & An, Y. (2014). Clinical significance of migration and invasion inhibitor protein expression in non-small‑cell lung cancer. Oncology Letters, 8, 2417-2422. https://doi.org/10.3892/ol.2014.2526
MLA
Wang, X., Liu, H., Wang, X., An, Y."Clinical significance of migration and invasion inhibitor protein expression in non-small‑cell lung cancer". Oncology Letters 8.6 (2014): 2417-2422.
Chicago
Wang, X., Liu, H., Wang, X., An, Y."Clinical significance of migration and invasion inhibitor protein expression in non-small‑cell lung cancer". Oncology Letters 8, no. 6 (2014): 2417-2422. https://doi.org/10.3892/ol.2014.2526
Copy and paste a formatted citation
x
Spandidos Publications style
Wang X, Liu H, Wang X and An Y: Clinical significance of migration and invasion inhibitor protein expression in non-small‑cell lung cancer. Oncol Lett 8: 2417-2422, 2014.
APA
Wang, X., Liu, H., Wang, X., & An, Y. (2014). Clinical significance of migration and invasion inhibitor protein expression in non-small‑cell lung cancer. Oncology Letters, 8, 2417-2422. https://doi.org/10.3892/ol.2014.2526
MLA
Wang, X., Liu, H., Wang, X., An, Y."Clinical significance of migration and invasion inhibitor protein expression in non-small‑cell lung cancer". Oncology Letters 8.6 (2014): 2417-2422.
Chicago
Wang, X., Liu, H., Wang, X., An, Y."Clinical significance of migration and invasion inhibitor protein expression in non-small‑cell lung cancer". Oncology Letters 8, no. 6 (2014): 2417-2422. https://doi.org/10.3892/ol.2014.2526
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