Open Access

Effects of co‑treatment with sulforaphane and autophagy modulators on uridine 5'-diphospho‑glucuronosyltransferase 1A isoforms and cytochrome P450 3A4 expression in Caco‑2 human colon cancer cells

  • Authors:
    • Min Wang
    • Jing-Yu Zhu
    • Shuo Chen
    • Ying Qing
    • Dong Wu
    • Ying-Min Lin
    • Ji-Zhuang Luo
    • Wei Han
    • Yan-Qing Li
  • View Affiliations

  • Published online on: September 15, 2014     https://doi.org/10.3892/ol.2014.2536
  • Pages: 2407-2416
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Abstract

Sulforaphane (SFN), which is highly enriched in cruciferous vegetables, has been investigated for its cancer chemopreventive properties and ability to induce autophagy. Uridine 5'‑diphospho (UDP)‑glucuronosyltransferase (UGT)1A induction is one of the mechanisms that is responsible for the cancer chemopreventive activity of SFN. The current study demonstrates that rapamycin may enhance the chemopreventive effects of SFN on Caco‑2 cells; this may be partially attributed to nuclear translocation of nuclear factor erythroid 2-related factor 2 (Nrf2)‑ and human pregnane X receptor (hPXR)‑mediated UGT1A1, UGT1A8 and UGT1A10 induction. These results indicate that targeting autophagy modulation may be a promising strategy for increasing the chemopreventive effects of SFN in cases of colon cancer.
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December-2014
Volume 8 Issue 6

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Spandidos Publications style
Wang M, Zhu J, Chen S, Qing Y, Wu D, Lin Y, Luo J, Han W and Li Y: Effects of co‑treatment with sulforaphane and autophagy modulators on uridine 5'-diphospho‑glucuronosyltransferase 1A isoforms and cytochrome P450 3A4 expression in Caco‑2 human colon cancer cells. Oncol Lett 8: 2407-2416, 2014.
APA
Wang, M., Zhu, J., Chen, S., Qing, Y., Wu, D., Lin, Y. ... Li, Y. (2014). Effects of co‑treatment with sulforaphane and autophagy modulators on uridine 5'-diphospho‑glucuronosyltransferase 1A isoforms and cytochrome P450 3A4 expression in Caco‑2 human colon cancer cells. Oncology Letters, 8, 2407-2416. https://doi.org/10.3892/ol.2014.2536
MLA
Wang, M., Zhu, J., Chen, S., Qing, Y., Wu, D., Lin, Y., Luo, J., Han, W., Li, Y."Effects of co‑treatment with sulforaphane and autophagy modulators on uridine 5'-diphospho‑glucuronosyltransferase 1A isoforms and cytochrome P450 3A4 expression in Caco‑2 human colon cancer cells". Oncology Letters 8.6 (2014): 2407-2416.
Chicago
Wang, M., Zhu, J., Chen, S., Qing, Y., Wu, D., Lin, Y., Luo, J., Han, W., Li, Y."Effects of co‑treatment with sulforaphane and autophagy modulators on uridine 5'-diphospho‑glucuronosyltransferase 1A isoforms and cytochrome P450 3A4 expression in Caco‑2 human colon cancer cells". Oncology Letters 8, no. 6 (2014): 2407-2416. https://doi.org/10.3892/ol.2014.2536