Acute basophilic leukemia presenting with maculopapular rashes and a gastric ulcer: A case report

Luo,Xiao‑Hua; Zhu,Yan; Tang,Xiao‑Qiong

doi:10.3892/ol.2014.2544

December-2014 Volume 8 Issue 6

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December-2014 Volume 8 Issue 6

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Case Report

Acute basophilic leukemia presenting with maculopapular rashes and a gastric ulcer: A case report

Authors:
- Xiao‑Hua Luo
- Yan Zhu
- Xiao‑Qiong Tang
View Affiliations / Copyright

Affiliations: Department of Hematology, The First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, P.R. China, Department of Hematology, Southwest Hospital, Third Military Medical University, Chongqing 400038, P.R. China
Pages: 2513-2516
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Published online on: September 17, 2014

https://doi.org/10.3892/ol.2014.2544
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Abstract

Acute basophilic leukemia (ABL) is a rare and poorly characterized form of leukemia. The case of a 65‑year‑old male who complained of dizziness, maculopapular skin lesions and melena is described in the current report. A gastroscopy was conducted and indicated a gastric antral ulcer. The diagnosis of ABL was determined due to characteristic cytomorphological features, the myeloid immunophenotype of the blast cells (identified to be positive for cluster of differentiation [CD]25 and CD123) in addition to the absence of the Philadelphia chromosome and a c‑kit D816V mutation. The patient initially demonstrated clinical improvement as a result of chemotherapy, however, subsequently deteriorated. The gastric and skin manifestations of ABL may be associated with excessive histamine release from basophilic cells. Thus, the administration of H1‑ and H2‑receptor antagonists, proton pump inhibitors and steroids is proposed in order to minimize these associated complications.

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Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Acute basophilic leukemia presenting with maculopapular rashes and a gastric ulcer: A case report

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