Gastric cancer following a liver transplantation for glycogen storage disease type Ia (von Gierke disease): A case report

Xiao,Hua; Bian,Jianmin; Zhang,Lei; Wang,Zhaoming; Ding,Aixing

doi:10.3892/ol.2014.2599

December-2014 Volume 8 Issue 6

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December-2014 Volume 8 Issue 6

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Case Report

Gastric cancer following a liver transplantation for glycogen storage disease type Ia (von Gierke disease): A case report

Authors:
- Hua Xiao
- Jianmin Bian
- Lei Zhang
- Zhaoming Wang
- Aixing Ding
View Affiliations / Copyright

Affiliations: Department of General Surgery, Nanjing First Hospital, Nanjing Medical University, Nanjing, Jiangsu 210006, P.R. China
Pages: 2803-2805
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Published online on: October 9, 2014

https://doi.org/10.3892/ol.2014.2599
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Abstract

Glycogen storage disease type Ia (GSD‑Ia; also termed von Gierke disease) is an inherited metabolic disorder resulting from a glucose‑6‑phosphatase deficiency. Liver transplantation is considered to be the most effective treatment for GSD‑Ia patients. In the present study, the case of a patient with GSD‑Ia who received a liver transplantation at 17 years of age is presented. During the 12 years following transplantation, the patient's quality of life markedly improved. However, recently, the patient was diagnosed with de novo gastric cancer following a biopsy. Thus, a total gastrectomy with lymph node dissection was performed and the tumor was histologically determined to be a poorly differentiated adenocarcinoma (histopathological stage, pT4N1M0). The patient recovered well and was discharged on postoperative day 10 without any complications. To the best of our knowledge, this is the first case of de novo gastric cancer in a patient with GSD‑Ia to be reported.

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Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Gastric cancer following a liver transplantation for glycogen storage disease type Ia (von Gierke disease): A case report

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