Bifocal juvenile papillomatosis as a marker of breast cancer: A case report and review of the literature

Wang,Tong; Li,Ya‑Qing; Liu,Hong; Fu,Xi-Lin; Tang,Shou‑Ching

doi:10.3892/ol.2014.2600

December-2014 Volume 8 Issue 6

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December-2014 Volume 8 Issue 6

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Case Report

Bifocal juvenile papillomatosis as a marker of breast cancer: A case report and review of the literature

Authors:
- Tong Wang
- Ya‑Qing Li
- Hong Liu
- Xi-Lin Fu
- Shou‑Ching Tang
View Affiliations / Copyright

Affiliations: Second Department of Breast Cancer, Tianjin Medical University Cancer Institute and Hospital, Ministry of Education, Tianjin 300060, P.R. China, Department of Breast Cancer Pathology and Research Laboratory, National Clinical Research Center for Cancer, Key Laboratories of Breast Cancer Prevention and Therapy, Tianjin Medical University Cancer Institute and Hospital, Ministry of Education, Tianjin 300060, P.R. China
Pages: 2587-2590
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Published online on: October 10, 2014

https://doi.org/10.3892/ol.2014.2600
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Abstract

Juvenile papillomatosis (JP), also termed Swiss cheese disease, is a rare and benign type of proliferative breast tumor that is specifically observed in children and adolescents. The majority of JP patients are Caucasian and exhibit a single breast mass. The current report presents an unusual case of bifocal JP in an 11‑year‑old Chinese female. The patient presented with a slow‑growing palpable mass in the upper outer quadrant of the left breast. Ultrasonography identified a further impalpable lesion in the lower outer quadrant of the ipsilateral breast. The preoperative clinical diagnosis of the two masses was fibroadenoma, however, following complete excision of the two tumors, histopathology revealed JP. Furthermore, the patient had a family history of breast cancer. The current report describes a review of the literature regarding the presentation, pathology, diagnosis, and treatment of JP and its association with breast carcinoma. In the current case, JP was associated with an increased risk of breast cancer in the patient, as well as the patient's elder female relatives; therefore, a more thorough medical follow‑up may prove prudent for those individuals with a high risk of developing breast cancer.

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Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Bifocal juvenile papillomatosis as a marker of breast cancer: A case report and review of the literature

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