Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Oncology Letters
Join Editorial Board Propose a Special Issue
Print ISSN: 1792-1074 Online ISSN: 1792-1082
Journal Cover
December-2014 Volume 8 Issue 6

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
December-2014 Volume 8 Issue 6

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article Open Access

Nitric oxide signaling pathway activation inhibits the immune escape of pancreatic carcinoma cells

  • Authors:
    • Yebin Lu
    • Juanjuan Hu
    • Weijia Sun
    • Xiaohui Duan
    • Xiong Chen
  • View Affiliations / Copyright

    Affiliations: Department of General Surgery, Xiangya Hospital, Central South University, Changsha, Hunan 410008, P.R. China
  • Pages: 2371-2378
    |
    Published online on: October 10, 2014
       https://doi.org/10.3892/ol.2014.2607
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

The aim of the present study was to investigate the effect of the nitric oxide signaling pathway on immune escape; thus, a tumorigenesis model was established using nude mice. The mice were inoculated with pancreatic carcinoma cells and divided into two groups, a glyceryl trinitrate (GTN) and a placebo group. When tumor volumes reached 150 mm3, the mice in the GTN group were treated with GTN transdermal patches (dose, 7.3 µg/h) while the mice in the placebo group were administered untreated patches. Following treatment, the tumor volume was recorded every 3‑4 days and after 28 days, the tumors were analyzed. The results indicated that GTN treatment may reduce the levels of soluble major histocompatibility complex class I chain‑related molecules, and natural killer group 2 member D, as well as inhibiting tumor growth.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

Figure 5

Figure 6

Figure 7

Figure 8

Figure 9

View References

1 

Seliger B and Massa C: The dark side of dendritic cells: Development and exploitation of tolerogenic activity that favor tumor outgrowth and immune escape. Front Immunol. 4:4192013.

2 

Groh V, Rhinehart R, Secrist H, Bauer S, Grabstein KH and Spies T: Broad tumor-associated expression and recognition by tumor-derived gamma delta T cells of MICA and MICB. Proc Natl Acad Sci USA. 96:6879–6884. 1999.

3 

Li K, Mandai M, Hamanishi J, Matsumura N, Suzuki A, Yagi H, Yamaguchi K, Baba T, Fujii S and Konishi I: Clinical significance of the NKG2D ligands, MICA/B and ULBP2 in ovarian cancer: high expression of ULBP2 is an indicator of poor prognosis. Cancer Immunol Immunother. 58:641–652. 2009.

4 

Diefenbach A, Jensen ER, Jamieson AM and Raulet DH: Rae1 and H60 ligands of the NKG2D receptor stimulate tumour immunity. Nature. 413:165–171. 2001.

5 

Groh V, Steinle A, Bauer S and Spies T: Recognition of stress-induced MHC molecu1es by intestina1 epithelial gammadelta T cells. Science. 279:1737–1740. 1998.

6 

Conejo-Garcia JR, Benencia F, Courreges MC, Khang E, Zhang L, Mohamed-Hadley A, Vinocur JM, Buckanovich RJ, Thompson CB, Levine B, et al: A tumor-associated NKG2D immunoreceptor ligand, induces activation and expansion of effector immune cells. Cancer Biol Ther. 2:446–451. 2003.

7 

Vivier E, Tomasello E and Paul P: Lymphocyte activation via NKG2D: towards a new paradigm in immune recognition? Curr Opin Immunol. 14:306–311. 2002.

8 

Holdenrieder S, Stieber P, Peterfi A, Nagel D, Steinle A and Salih HR: Soluble MICA in malignant diseases. Int J Cancer. 118:684–687. 2006.

9 

Ota KT, Pierre VJ, Ploski JE, Queen K and Schafe GE: The NO-cGMP-PKG signaling pathway regulates synaptic plasticity and fear memory consolidation in the lateral amygdala via activation of ERK/MAP kinase. Learn Mem. 15:792–805. 2008.

10 

Bonthius DJ, Karacay B, Dai D, Hutton A and Pantazis NJ: The NO-cGMP-PKG pathway plays an essential role in the acquisition of ethanol resistance by cerebellar granule neurons. Neurotoxicol Teratol. 26:47–57. 2004.

11 

Bredt DS and Snyder SH: Nitric oxide, a novel neuronal messenger. Neuron. 8:3–11. 1992.

12 

Son H, Lu YF, Zhuo M, Arancio O, Kandel ER and Hawkins RD: The specific role of cGMP in hippocampal LTP. Learn Mem. 5:231–245. 1998.

13 

Denninger JW and Marletta MA: Guanylate cyclase and the NO/cGMP signaling pathway. Biochim Biophys Acta. 1411:334–350. 1999.

14 

Arancio O, Antonova I, Gambaryan S, Lohmann SM, Wood JS, Lawrence DS and Hawkins RD: Presynaptic role of cGMP dependent protein kinase during long-lasting potentiation. J Neurosci. 21:143–149. 2001.

15 

Bradford MM: A rapid and sensitive for the quantitation of microgram quantitites of protein utilizing the principle of protein-dye binding. Anal Biochem. 72:248–254. 1976.

16 

Siemens DR, Hu N, Sheikhi AK, Chung E, Frederiksen LJ, Pross H and Graham CH: Hypoxia increases tumor cell shedding of MHC Class I chain-related molecule: role of nitric oxide. Cancer Res. 68:4746–4753. 2008.

17 

Jiang H, Tian YP, Dong Z and Zhang YD: Microarray technique for observing the regulation of glyceryl trinitrate on angiogenesis gene expression of Hela. Xian Dai Kang Fu. 29:6413–6415. 2004.

18 

Cai YG, Yang SM and Fang DC: Effects of heparin enzyme on the occurrence, development, metastasis and prognosis rehabilitation of tumor. Xian Dai Kang Fu. 14:2086–2087. 2003.

19 

Das T, Sa G, Chattopadhyay S and Ray PK: Protein A-induced apoptosis of cancer cells is effected by soluble immune mediators. Cancer Immunol Immunother. 51:376–380. 2002.

20 

Feelisch M, Brands F and Kelm M: Human endothelial cells bioactivate organic nitrates to nitric oxide: implications for the reinforcement of endothelial defence mechanisms. Eur J Clin Invest. 25:737–745. 1995.

21 

Chen Z, Zhang J and Stamler JS: Identification of the enzymatic mechanism of nitroglycerin bioactivation. Proc Natl Acad Sci USA. 99:8306–8311. 2002.

22 

Kearney MF, Brien JF, Marks GS, Lei H and Nakatsu K: Thiol agents separate nitric oxide formation from vasodilation induced by glyceryl trinitrate. Drug Metab Dispos. 26:547–551. 1998.

23 

Ji Y, Akerboom TP and Sies H: Microsomal formation of S-nitrosoglutathione from organic nitrites: possible role of membrane-bound glutathione transferase. Biochem J. 313:377–380. 1996.

24 

Thomas WJ, Thomas DL, Knezetic JA and Adrian TE: The role of oxygen-derived free radicals and nitric oxide in cytokine-induced anti-proliferation of pancreatic cancer cells. Pancreas. 24:161–168. 2002.

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Lu Y, Hu J, Sun W, Duan X and Chen X: Nitric oxide signaling pathway activation inhibits the immune escape of pancreatic carcinoma cells. Oncol Lett 8: 2371-2378, 2014.
APA
Lu, Y., Hu, J., Sun, W., Duan, X., & Chen, X. (2014). Nitric oxide signaling pathway activation inhibits the immune escape of pancreatic carcinoma cells. Oncology Letters, 8, 2371-2378. https://doi.org/10.3892/ol.2014.2607
MLA
Lu, Y., Hu, J., Sun, W., Duan, X., Chen, X."Nitric oxide signaling pathway activation inhibits the immune escape of pancreatic carcinoma cells". Oncology Letters 8.6 (2014): 2371-2378.
Chicago
Lu, Y., Hu, J., Sun, W., Duan, X., Chen, X."Nitric oxide signaling pathway activation inhibits the immune escape of pancreatic carcinoma cells". Oncology Letters 8, no. 6 (2014): 2371-2378. https://doi.org/10.3892/ol.2014.2607
Copy and paste a formatted citation
x
Spandidos Publications style
Lu Y, Hu J, Sun W, Duan X and Chen X: Nitric oxide signaling pathway activation inhibits the immune escape of pancreatic carcinoma cells. Oncol Lett 8: 2371-2378, 2014.
APA
Lu, Y., Hu, J., Sun, W., Duan, X., & Chen, X. (2014). Nitric oxide signaling pathway activation inhibits the immune escape of pancreatic carcinoma cells. Oncology Letters, 8, 2371-2378. https://doi.org/10.3892/ol.2014.2607
MLA
Lu, Y., Hu, J., Sun, W., Duan, X., Chen, X."Nitric oxide signaling pathway activation inhibits the immune escape of pancreatic carcinoma cells". Oncology Letters 8.6 (2014): 2371-2378.
Chicago
Lu, Y., Hu, J., Sun, W., Duan, X., Chen, X."Nitric oxide signaling pathway activation inhibits the immune escape of pancreatic carcinoma cells". Oncology Letters 8, no. 6 (2014): 2371-2378. https://doi.org/10.3892/ol.2014.2607
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team