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December-2014 Volume 8 Issue 6

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International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

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Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

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Article

Hepatoma upregulated protein expression is involved in the pathogenesis of human breast carcinogenesis

  • Authors:
    • Jin Chen
    • Qiu‑Jun Liu
    • Da Wang
    • Xian‑Yao Zhou
    • Ding Xiong
    • Hong-Jiang Li
    • Chang-Long Li
  • View Affiliations / Copyright

    Affiliations: Department of Biochemistry and Molecular Biology, Sichuan University, Chengdu, Sichuan 610072, P.R. China, Department of Thyroid and Breast Surgery, West China Hospital of Sichuan University, Chengdu, Sichuan 610072, P.R. China
  • Pages: 2543-2548
    |
    Published online on: October 13, 2014
       https://doi.org/10.3892/ol.2014.2614
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Abstract

In the last decade, the overexpression of hepatoma upregulated protein (HURP) has been reported in hepatocellular carcinoma, adrenocortical tumors and urogenital carcinoma. However, the role of HURP in breast cancer remains unknown. In the present study, a comprehensive analysis was performed to examine the HURP expression level in 43 breast cancer tumor samples and paired adjacent normal tissues. The correlation between the HURP expression level and the clinicopathological characteristics was evaluated. The role of HURP in breast cancer was investigated by quantitative polymerase chain reaction, western blot analysis and cell proliferation assays. HURP expression was found to be significantly increased in the breast cancer samples. The HURP expression level was higher in the tumors with advanced‑grade metastasis and was strongly associated with tumor‑node‑metastasis staging (P=0.003). Transfection and cell proliferation assays suggested that the suppression of HURP expression or the interference in HURP activity in the breast cancer cells inhibited cell proliferation significantly. These data suggest that HURP is associated with the degree of malignancy and the proliferation of breast cancer. HURP could be a tumor biomarker for prognosis and a potential therapeutic drug target for human breast cancer.
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1 

Polyak K: Breast cancer: origins and evolution. J Clin Invest. 117:3155–3163. 2007.

2 

Bray F, McCarron P and Parkin DM: The changing global patterns of female breast cancer incidence and mortality. Breast Cancer Res. 6:229–239. 2004.

3 

Downs-Holmes C and Silverman P: Breast cancer: overview & updates. Nurse Pract. 36:20–26. 2011.

4 

Sauer G, Körner R, Hanisch A, Ries A, Nigg EA and Silljé HH: Proteome analysis of the human mitotic spindle. Mol Cell Proteomics. 4:35–43. 2005.

5 

Tsou AP, Yang CW, Huang CY, et al: Identification of a novel cell cycle regulated gene, HURP, overexpressed in human hepatocellular carcinoma. Oncogene. 22:298–307. 2003.

6 

Silljé HH, Nagel S, Körner R and Nigg EA: HURP is a Ran-importin beta-regulated protein that stabilizes kinetochore microtubules in the vicinity of chromosomes. Curr Biol. 16:731–742. 2006.

7 

Koffa MD, Casanova CM, Santarella R, et al: HURP is part of a Ran-dependent complex involved in spindle formation. Curr Biol. 16:743–754. 2006.

8 

Yu CT, Hsu JM, Lee YC, et al: Phosphorylation and stabilization of HURP by Aurora-A: implication of HURP as a transforming target of Aurora-A. Mol Cell Biol. 25:5789–5800. 2005.

9 

Sasai K, Parant JM, Brandt ME, et al: Targeted disruption of Aurora A causes abnormal mitotic spindle assembly, chromosome misalignment and embryonic lethality. Oncogene. 27:4122–4127. 2008.

10 

Wong J, Lerrigo R, Jang CY and Fang G: Aurora A regulates the activity of HURP by controlling the accessibility of its microtubule-binding domain. Mol Biol Cell. 19:2083–2091. 2008.

11 

Wong J and Fang G: HURP controls spindle dynamics to promote proper interkinetochore tension and efficient kinetochore capture. J Cell Biol. 173:879–891. 2006.

12 

Negrini S, Gorgoulis VG and Halazonetis TD: Genomic instability - an evolving hallmark of cancer. Nat Rev Mol Cell Biol. 11:220–228. 2010.

13 

Bakhoum SF and Compton DA: Kinetochores and disease: keeping microtubule dynamics in check! Curr Opin Cell Biol. 24:64–70. 2012.

14 

Fragoso MC, Almeida MQ, Mazzuco TL, et al: Combined expression of BUB1B, DLGAP5, and PINK1 as predictors of poor outcome in adrenocortical tumors: validation in a Brazilian cohort of adult and pediatric patients. Eur J Endocrinol. 166:61–67. 2012.

15 

Chiu AW, Huang YL, Huan SK, et al: Potential molecular marker for detecting transitional cell carcinoma. Urology. 60:181–185. 2002.

16 

Lakhani and Sunil R: WHO Classification of Tumours of the Breast. 4th edition. International Agency for Research on Cancer; Lyon, France: 2012

17 

Singletary SE and Greene FL: Revision of breast cancer staging: The 6th edition of the TNM Classification. Seminars in Surgical Oncology. 21. Wiley Subscription Services, Inc., A Wiley Company; 2003

18 

Kuo TC, Chang PY, Huang SF, Chou CK and Chao CC: Knockdown of HURP inhibits the proliferation of hepacellular carcinoma cells via downregulation of gankyrin and accumulation of p53. Biochem Pharmacol. 83:758–768. 2012.

19 

Betz MJ and Beuschlein F: Diagnosis: Novel molecular signatures for adrenocortical carcinoma. Nat Rev Endocrinol. 5:297–299. 2009.

20 

Huang YL, Chiu AW, Huan SK, et al: Prognostic significance of hepatoma-up-regulated protein expression in patients with urinary bladder transitional cell carcinoma. Anticancer Res. 23:2729–2733. 2003.

21 

Wang YC, Lee YH, Huang GC, et al: Enhanced transformation and chemosensitivity of NIH3T3 cells transduced with hepatoma upregulated protein. Biochem Biophys Res Commun. 340:244–249. 2006.

22 

Zhao L, Qin LX, Ye QH, et al: KIAA0008 gene is associated with invasive phenotype of human hepatocellular carcinoma - a functional analysis. J Cancer Res Clin Oncol. 130:719–727. 2004.

23 

Chen X, Thiaville MM, Chen L, et al: Defining NOTCH3 target genes in ovarian cancer. Cancer Res. 72:2294–2303. 2012.

24 

Ye F, Tan L, Yang Q, et al: HURP regulates chromosome congression by modulating kinesin Kif18A function. Curr Biol. 21:1584–1591. 2011.

25 

Zelnak AB: Clinical pharmacology and use of microtubule-targeting agents in cancer therapy. Methods Mol Med. 137:209–234. 2007.

26 

Jordan MA and Wilson L: Microtubules as a target for anticancer drugs. Nat Rev Cancer. 4:253–265. 2004.

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Copy and paste a formatted citation
Spandidos Publications style
Chen J, Liu QJ, Wang D, Zhou XY, Xiong D, Li H and Li C: Hepatoma upregulated protein expression is involved in the pathogenesis of human breast carcinogenesis. Oncol Lett 8: 2543-2548, 2014.
APA
Chen, J., Liu, Q., Wang, D., Zhou, X., Xiong, D., Li, H., & Li, C. (2014). Hepatoma upregulated protein expression is involved in the pathogenesis of human breast carcinogenesis. Oncology Letters, 8, 2543-2548. https://doi.org/10.3892/ol.2014.2614
MLA
Chen, J., Liu, Q., Wang, D., Zhou, X., Xiong, D., Li, H., Li, C."Hepatoma upregulated protein expression is involved in the pathogenesis of human breast carcinogenesis". Oncology Letters 8.6 (2014): 2543-2548.
Chicago
Chen, J., Liu, Q., Wang, D., Zhou, X., Xiong, D., Li, H., Li, C."Hepatoma upregulated protein expression is involved in the pathogenesis of human breast carcinogenesis". Oncology Letters 8, no. 6 (2014): 2543-2548. https://doi.org/10.3892/ol.2014.2614
Copy and paste a formatted citation
x
Spandidos Publications style
Chen J, Liu QJ, Wang D, Zhou XY, Xiong D, Li H and Li C: Hepatoma upregulated protein expression is involved in the pathogenesis of human breast carcinogenesis. Oncol Lett 8: 2543-2548, 2014.
APA
Chen, J., Liu, Q., Wang, D., Zhou, X., Xiong, D., Li, H., & Li, C. (2014). Hepatoma upregulated protein expression is involved in the pathogenesis of human breast carcinogenesis. Oncology Letters, 8, 2543-2548. https://doi.org/10.3892/ol.2014.2614
MLA
Chen, J., Liu, Q., Wang, D., Zhou, X., Xiong, D., Li, H., Li, C."Hepatoma upregulated protein expression is involved in the pathogenesis of human breast carcinogenesis". Oncology Letters 8.6 (2014): 2543-2548.
Chicago
Chen, J., Liu, Q., Wang, D., Zhou, X., Xiong, D., Li, H., Li, C."Hepatoma upregulated protein expression is involved in the pathogenesis of human breast carcinogenesis". Oncology Letters 8, no. 6 (2014): 2543-2548. https://doi.org/10.3892/ol.2014.2614
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