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Oncology Letters
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Print ISSN: 1792-1074 Online ISSN: 1792-1082
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January-2015 Volume 9 Issue 1

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International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

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International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

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Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

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Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

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Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

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Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

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Case Report

Synchronous primary cancers of the thyroid and breast: A case report and review of the literature

  • Authors:
    • Li Liu
    • Jing Shi
    • Fengfeng Mao
    • Jinli Wei
    • Deyuan Fu
    • Jiaxin Zhang
  • View Affiliations / Copyright

    Affiliations: Department of Thyroid and Breast Surgery, Clinical Medical College of Yangzhou University, Subei People's Hospital of Jiangsu Province, Yangzhou, Jiangsu 225001, P.R. China
  • Pages: 351-354
    |
    Published online on: October 17, 2014
       https://doi.org/10.3892/ol.2014.2625
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Abstract

The current report presents the case of a 41‑year‑old female exhibiting synchronous primary cancers of the thyroid and breast. Pathological examination of a tissue sample following biopsy identified papillary carcinoma of the thyroid and invasive ductal carcinoma of the breast to provide a definitive diagnosis of synchronous primary tumors. The patient underwent a modified radical mastectomy and total thyroidectomy. Following regular adjuvant chemotherapy with cyclophosphamide (800 mg), doxorubicin (100 mg) and paclitaxel (120 mg), once every three weeks for 3.5 months, oral levothyroxine and endocrinotherapy was recommended. Two years after the initial diagnosis, the patient was healthy with no disease recurrence. To the best of our knowledge, no association has been identified between the etiology and diagnoses of the two synchronous primary tumors. Thus, the aim of the current report was to improve the understanding of synchronous primary tumors of the thyroid and breast by presenting a review of the associated literature regarding breast and thyroid cancer. The mechanisms of synchronous neoplasms have only recently been elucidated, however, misdiagnosis is common. Clinicians are, therefore, advised to carefully examine patients with thyroid or breast cancer to avoid an incorrect or misdiagnosis. Furthermore, the present report aims to provide a reference for the cancer database, since the majority of analyses of rare diseases are derived from case reports. To improve the understanding of synchronous primary cancers of the thyroid and breast, an analysis of recent studies regarding the underlying mechanisms of synchronous primary cancers was also undertaken.
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1 

Chalstrey LJ and Benjamin B: High incidence of breast cancer in thyroid cancer patients. Br J Cancer. 20:670–675. 1966. View Article : Google Scholar : PubMed/NCBI

2 

Chen AY, Levy L, Goepfert H, et al: The development of breast carcinoma in women with thyroid carcinoma. Cancer. 92:225–231. 2001. View Article : Google Scholar : PubMed/NCBI

3 

Kim C, Bi X, Pan D, et al: The risk of second cancers after diagnosis of primary thyroid cancer is elevated in thyroid microcarcinomas. Thyroid. 23:575–582. 2013. View Article : Google Scholar :

4 

Simon MS, Tang MT, Bernstein L, et al: Do thyroid disorders increase the risk of breast cancer? Cancer Epidemiol Biomarkers Prev. 11:1574–1578. 2002.PubMed/NCBI

5 

Murray SE, Schneider DF, Bauer PS, et al: Synchronous and antecedent nonthyroidal malignancies in patients with papillary thyroid carcinoma. J Am Coll Surg. 216:1174–1180. 2013. View Article : Google Scholar : PubMed/NCBI

6 

Kim WG, Zhu X, Kim DW, et al: Reactivation of the silenced thyroid hormone receptor-β gene expression delays thyroid tumor progression. Endocrinology. 154:25–35. 2013. View Article : Google Scholar :

7 

Ling Y, Xu X, Hao J, et al: Aberrant methylation of the THRB gene in tissue and plasma of breast cancer patients. Cancer Genet Cytogenet. 196:140–145. 2010. View Article : Google Scholar : PubMed/NCBI

8 

Guigon CJ, Kim DW, Willingham MC and Cheng SY: Mutation of thyroid hormone receptor-β in mice predisposes to the development of mammary tumors. Oncogene. 30:3381–3390. 2011. View Article : Google Scholar : PubMed/NCBI

9 

Sar P, Peter R, Rath B, et al: 3, 3′5 Triiodo L thyronine induces apoptosis in human breast cancer MCF-7 cells, repressing SMP30 expression through negative thyroid response elements. PLoS One. 6:e208612011. View Article : Google Scholar

10 

Muller I, Giani C, Zhang L, et al: Does thyroid peroxidase provide an antigenic link between thyroid autoimmunity and breast cancer? Int J Cancer. 134:1706–1714. 2014. View Article : Google Scholar

11 

Carrera-González MP, Ramírez-Expósito MJ, Mayas MD, et al: Local thyroid renin-angiotensin system in experimental breast cancer. Life Sci. 93:1004–1009. 2013. View Article : Google Scholar : PubMed/NCBI

12 

Gaertner FC, Rohde F, Mueller J, et al: Endogenous expression of the sodium iodide symporter mediates uptake of iodide in murine models of colorectal carcinoma. Int J Cancer. 125:2783–2791. 2009. View Article : Google Scholar : PubMed/NCBI

13 

Smith VE, Franklyn JA and McCabe CJ: Expression and function of the novel proto-oncogene PBF in thyroid cancer: a new target for augmenting radioiodine uptake. J Endocrinol. 210:157–163. 2011. View Article : Google Scholar : PubMed/NCBI

14 

Chowdhury UR, Samant RS, Fodstad O and Shevde LA: Emerging role of nuclear protein 1 (NUPR1) in cancer biology. Cancer Metastasis Rev. 28:225–232. 2009. View Article : Google Scholar : PubMed/NCBI

15 

Knappskog S, Myklebust LM, Busch C, et al: RINF (CXXC5) is overexpressed in solid tumors and is an unfavorable prognostic factor in breast cancer. Ann Oncol. 22:2208–2215. 2011. View Article : Google Scholar : PubMed/NCBI

16 

Liu MY, Guo HP, Hong CQ, et al: Up-regulation of nuclear receptor coactivator amplified in breast cancer-1 in papillary thyroid carcinoma correlates with lymph node metastasis. Clin Transl Oncol. 15:947–952. 2013. View Article : Google Scholar : PubMed/NCBI

17 

Wang C, Mayer JA, Mazumdar A and Brown PH: The rearranged during transfection/papillary thyroid carcinoma tyrosine kinase is an estrogen-dependent gene required for the growth of estrogen receptor positive breast cancer cells. Breast Cancer Res Treat. 133:487–500. 2012. View Article : Google Scholar :

18 

Ni Y, He X, Chen J, Moline J, Mester J, Orloff MS, Ringel MD and Eng C: Germline SDHx variants modify breast and thyroid cancer risks in Cowden and Cowden-like syndrome via FAD/NAD-dependant destabilization of p53. Hum Mol Genet. 21:300–310. 2012. View Article : Google Scholar :

19 

Van Fossen VL, Wilhelm SM, Eaton JL and McHenry CR: Association of thyroid, breast and renal cell cancer: a population-based study of the prevalence of second malignancies. Ann Surg Oncol. 20:1341–1347. 2013. View Article : Google Scholar

20 

Wei X, Li Y, Zhang S, et al: Evaluation of microvascularization in focal salivary gland lesions by contrast-enhanced ultrasonography (CEUS) and Color Doppler sonography. Clin Hemorheol Microcirc. 54:259–271. 2013.PubMed/NCBI

21 

Jiskra J, Barkmanova J, Limanova Z, et al: Thyroid autoimmunity occurs more frequently in women with breast cancer compared to women with colorectal cancer and controls but it has no impact on relapse-free and overall survival. Oncol Rep. 18:1603–1611. 2007.PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Liu L, Shi J, Mao F, Wei J, Fu D and Zhang J: Synchronous primary cancers of the thyroid and breast: A case report and review of the literature. Oncol Lett 9: 351-354, 2015.
APA
Liu, L., Shi, J., Mao, F., Wei, J., Fu, D., & Zhang, J. (2015). Synchronous primary cancers of the thyroid and breast: A case report and review of the literature. Oncology Letters, 9, 351-354. https://doi.org/10.3892/ol.2014.2625
MLA
Liu, L., Shi, J., Mao, F., Wei, J., Fu, D., Zhang, J."Synchronous primary cancers of the thyroid and breast: A case report and review of the literature". Oncology Letters 9.1 (2015): 351-354.
Chicago
Liu, L., Shi, J., Mao, F., Wei, J., Fu, D., Zhang, J."Synchronous primary cancers of the thyroid and breast: A case report and review of the literature". Oncology Letters 9, no. 1 (2015): 351-354. https://doi.org/10.3892/ol.2014.2625
Copy and paste a formatted citation
x
Spandidos Publications style
Liu L, Shi J, Mao F, Wei J, Fu D and Zhang J: Synchronous primary cancers of the thyroid and breast: A case report and review of the literature. Oncol Lett 9: 351-354, 2015.
APA
Liu, L., Shi, J., Mao, F., Wei, J., Fu, D., & Zhang, J. (2015). Synchronous primary cancers of the thyroid and breast: A case report and review of the literature. Oncology Letters, 9, 351-354. https://doi.org/10.3892/ol.2014.2625
MLA
Liu, L., Shi, J., Mao, F., Wei, J., Fu, D., Zhang, J."Synchronous primary cancers of the thyroid and breast: A case report and review of the literature". Oncology Letters 9.1 (2015): 351-354.
Chicago
Liu, L., Shi, J., Mao, F., Wei, J., Fu, D., Zhang, J."Synchronous primary cancers of the thyroid and breast: A case report and review of the literature". Oncology Letters 9, no. 1 (2015): 351-354. https://doi.org/10.3892/ol.2014.2625
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