Characterization of uncommon portosystemic collateral circulations in patients with hepatic cirrhosis

Wu,Qin; Shen,Lijun; Chu,Jindong; Ma,Xuemei; Jin,Bo; Meng,Fanping; Chen,Jinpin; Wang,Yanling; Wu,Libing; Han,Jun; Zhang,Wenhui; Ma,Wei; Wang,Huaming; Li,Hanwei

doi:10.3892/ol.2014.2626

January-2015 Volume 9 Issue 1

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January-2015 Volume 9 Issue 1

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Article

Characterization of uncommon portosystemic collateral circulations in patients with hepatic cirrhosis

Authors:
- Qin Wu
- Lijun Shen
- Jindong Chu
- Xuemei Ma
- Bo Jin
- Fanping Meng
- Jinpin Chen
- Yanling Wang
- Libing Wu
- Jun Han
- Wenhui Zhang
- Wei Ma
- Huaming Wang
- Hanwei Li
View Affiliations / Copyright

Affiliations: Liver Cirrhosis Therapeutic Center, 302 Hospital of the People's Liberation Army, Beijing 100039, P.R. China
Pages: 347-350
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Published online on: October 22, 2014

https://doi.org/10.3892/ol.2014.2626
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Abstract

The purpose of the present study was to characterize uncommon portosystemic collateral circulation in hepatic cirrhosis. Portosystemic uncommon collateral circulation (UCC) was detected, characterized and evaluated by a combination of spiral computed tomography angiography, three‑dimensional imaging angiography and electronic gastroscopy in patients diagnosed with hepatic cirrhosis. In total, 118 cases with UCC were detected from a pool of 700 hepatic cirrhosis patients with portal hypertension. The incidence was 16.86% and included cases with splenic‑renal, gastro‑renal, paravertebral, retroperitoneal, gastric‑splenic and cardio‑phrenic angle vein shunts. The occurrence rate of UCC formation increased with the Child‑Pugh grade. Compared with common collateral circulations, the incidence of severe esophageal or gastric fundus varicose veins, severe portal hypertensive gastropathy and the incidence of a large quantity of ascites was much lower in the patients with UCC (P<0.01), whereas the incidence of hepatic encephalopathy and chronic elevated blood ammonia levels was significantly higher (P<0.01). The incidence of uncommon portosystemic collateral circulation is extremely common in patients with liver cirrhosis and is associated with the Child‑Pugh grades of hepatic function. UCC can aid in the relief of the complications derived from portal hypertension, but it may increase the incidence of hepatic encephalopathy and chronic elevated blood ammonia levels.

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1	Moubarak E, Bouvier A, Boursier J, et al: Portosystemic collateral vessels in liver cirrhosis: a three-dimensional MDCT pictorial review. Abdom Imaging. 37:746–766. 2012. View Article : Google Scholar
2	Szczepanik AB, Proniewski J and Huszcza S: Portal venous system after endoscopic sclerotherapy of esophageal varices in patients with liver cirrhosis - prospective study with Doppler sonography. Hepatogastroenterology. 52:1448–1451. 2005.PubMed/NCBI
3	Gao L, Yang F, Ren C, et al: Diagnosis of cirrhotic portal hypertension and compensatory circulation using transsplenic portal scintigraphy with (99m)Tc-phytate. J Nuc Med. 51:52–56. 2010. View Article : Google Scholar
4	Cholongitas E, Papatheodoridis GV, Vangeli M, et al: Systematic review: the model for end-stage liver disease - should it replace Child-Pugh’s classification for assessing prognosis in cirrhosis? Aliment Pharmacol Ther. 22:1079–1089. 2005. View Article : Google Scholar : PubMed/NCBI
5	Lin D, Wu X, Ji X, et al: A novel canine model of portal vein stenosis plus thioacetamide administration-induced cirrhotic portal hypertension with hypersplenism. Cell Biochem Biophys. 62:245–255. 2012. View Article : Google Scholar
6	Iwakiri Y: Endothelial dysfunction in the regulation of cirrhosis and portal hypertension. Liver Int. 32:199–213. 2012. View Article : Google Scholar
7	Tarantino G, Citro V, Conca P, et al: What are the implications of the spontaneous splenic-renal shunts in liver cirrhosis? BMC Gastroenterol. 9:892009. View Article : Google Scholar
8	Kim MY, Baik SK and Lee SS: Hemodynamic alterations in cirrhosis and portal hypertension. Korean J Hepatol. 16:347–352. 2010. View Article : Google Scholar
9	Kim SH, Lee JM, Choi JY, et al: Changes of portosystemic collaterals and splenic volume on CT after liver transplantation and factors influencing those changes. AJR Am J Roentgenol. 191:W8–W16. 2008. View Article : Google Scholar : PubMed/NCBI
10	Zeng DB, Dai CZ, Lu SC, et al: Abnormal splenic artery diameter/hepatic artery diameter ratio in cirrhosis-induced portal hypertension. World J Gastroenterol. 19:1292–1298. 2013. View Article : Google Scholar : PubMed/NCBI
11	Møller S, Bendtsen F and Henriksen JH: Splanchnic and systemic hemodynamic derangement in decompensated cirrhosis. Can J Gastroenterol. 15:94–106. 2001.PubMed/NCBI
12	Dooley JS, Lok A, Burroughs AK and Heathcote J: Sherlock’s Diseases of the Liver and Biliary System. 12th edition. Wiley-Blackwell; New York, NY: 2011, View Article : Google Scholar
13	Ito K, Koike S, Shimizu A, et al: Portal venous system: evaluation with unenhanced MR angiography with a single-breath-hold ECG-synchronized 3D half-Fourier fast spin-echo sequence. AJR Am J Roentgenol. 191:550–554. 2008. View Article : Google Scholar : PubMed/NCBI
14	Bhutto AR, Abbasi A, Butt N, Khan A and Munir SM: Hepatic vein waveform in liver cirrhosis: correlation with Child’s class and size of varices. J Pak Med Assoc. 62:794–797. 2012.
15	Yilmaz VT, Eken C, Avci AB, et al: Relationship of increased serum brain natriuretic peptide levels with hepatic failure, portal hypertension and treatment in patients with cirrhosis. Turk J Gastroenterol. 21:381–386. 2010.
16	Hsin IF, Wang SS, Huang HC, et al: Portosystemic collaterals are not prerequisites for the development of hepatic encephalopathy in cirrhotic rats. J Chin Med Assoc. 75:3–9. 2012. View Article : Google Scholar : PubMed/NCBI

Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Characterization of uncommon portosystemic collateral circulations in patients with hepatic cirrhosis

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