Paratesticular sarcomas: A report of seven cases

Ünlü,Yaşar; Huq,Gülben  Erdem; Özyalvaçlı,Gülzade; Zengin,Mehmet; Koca,Sevim  Baykal; Yücetas,Uğur; Bozkurt,Erol  Rüştü; Behzatoğlu,Kemal

doi:10.3892/ol.2014.2629

January-2015 Volume 9 Issue 1

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January-2015 Volume 9 Issue 1

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Article

Paratesticular sarcomas: A report of seven cases

Authors:
- Yaşar Ünlü
- Gülben Erdem Huq
- Gülzade Özyalvaçlı
- Mehmet Zengin
- Sevim Baykal Koca
- Uğur Yücetas
- Erol Rüştü Bozkurt
- Kemal Behzatoğlu
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Affiliations: Department of Pathology, Konya Education and Research Hospital, Konya 42014, Turkey, Department of Pathology, Istanbul Education and Research Hospital, Istanbul 34098, Turkey, Department of Pathology, Faculty of Medicine, Izzet Baysal University, Bolu 14012, Turkey, Department of Pathology, Şırnak Hospital, Şırnak 73002, Turkey, Department of Pathology, Patnos Hospital, Ağrı 04001, Turkey, Department of Urology, Istanbul Education and Research Hospital, Istanbul 34098, Turkey
Pages: 308-312
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Published online on: October 23, 2014

https://doi.org/10.3892/ol.2014.2629
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Abstract

Primary tumors of the paratesticular region are rare, with paratesticular sarcomas constituting a major proportion of these tumors, particularly in the elderly. The paratesticular region consists of mesothelial, various epithelial and mesenchymal cells and may therefore give rise to a number of tumors with various behaviors. Defining the association between the paratesticular mass and the testicle, and differentiation between benign and malignant masses using radiology is challenging, therefore the mass is usually considered to be malignant and radical orchiectomy with high ligation is performed. The present study reports the cases of seven patients with tumors of the paratesticular region and presents the clinical and significant histological features of the tumors. In total, two patients suffered from dedifferentiated liposarcoma (DDLS), two exhibited leiomyosarcoma, two exhibited low‑grade fibromyxoid sarcoma and one case of undifferentiated pleomorphic sarcoma was identified. Radical orchiectomy with high ligation was performed in five cases; simple orchiectomy was performed in one case and excisional biopsy was performed in the remaining case. A leiomyosarcomatous and epithelial membrane antigen (EMA) positive whorl pattern was observed during microscopy in the two DDLS cases. Additionally, one of the low‑grade fibromyxoid sarcoma patients exhibited pleomorphism and mitosis in focal areas. To the best of our knowledge, the present study is the second time low‑grade fibromyxoid sarcoma cases with paratesticular localization have been reported in the literature. Of the seven cases, four patients succumbed to the disease, one patient is living with the disorder and the two cases of DDLS are living without the disease. Paratesticular sarcomas are often aggressive and a multidisciplinary approach is required for the diagnosis and treatment of these tumors.

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Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Paratesticular sarcomas: A report of seven cases

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