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Article

Tumor size predicts prognosis of head and neck synovial cell sarcoma

  • Authors:
    • Alimujiang Wushou
    • Xin‑Chao Miao
  • View Affiliations / Copyright

    Affiliations: Cancer Research Institute, Fudan University Shanghai Cancer Center; Department of Oncology, Shanghai Medical College, Fudan University, Shanghai 200032, P.R. China, Department of Oral and Maxillofacial Surgery, Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200011, P.R. China
  • Pages: 381-386
    |
    Published online on: October 24, 2014
       https://doi.org/10.3892/ol.2014.2634
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Abstract

Head and neck synoviosarcoma (HNSS) is uncommon. To the best of our knowledge, the specific clinicopathological characteristics, treatment outcome and prognostic factors of HNSS were uninvestigated at the time of writing, so a meta‑analysis was performed. An online data collection was carried out using PubMed and Google Scholar. Studies that reported primary HNSS and the treatment, follow‑up time and outcome were chosen for the present study. In total, 93 cases from 26 studies were included for analysis. The study sample consisted of 55 males and 38 females and the median age was 32.1 years (range, 4‑76 years). The median follow‑up period was 62.1 months (range, 1‑373 months). The tumor size was correlated with local recurrence and metastasis of HNSS, as well as with mortality (P=0.001, P<0.0001 and P<0.0001, respectively). The three‑year, five‑year and 10‑year survival rates were 82.1, 80.4 and 78.2% for treatment with surgery alone, and 88.5, 85.5 and 82% for treatment with surgery plus radiotherapy, respectively. A significant tumor size‑dependent difference was found between the overall survival (OS) rates (P<0.0001), as tumors that were >5.0 cm in diameter were associated with a worse OS rate (hazard ratio, 6.460; 95% confidence interval, 206‑18.917; P=0.001). The tumor size was found to be an independent adverse prognostic factor for the OS of HNSS patients. In conclusion, surgical excision is a mainstream treatment of HNSS and post‑operative adjuvant radiotherapy improves the OS rate of HNSS patients.
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Copy and paste a formatted citation
Spandidos Publications style
Wushou A and Miao XC: Tumor size predicts prognosis of head and neck synovial cell sarcoma. Oncol Lett 9: 381-386, 2015.
APA
Wushou, A., & Miao, X. (2015). Tumor size predicts prognosis of head and neck synovial cell sarcoma. Oncology Letters, 9, 381-386. https://doi.org/10.3892/ol.2014.2634
MLA
Wushou, A., Miao, X."Tumor size predicts prognosis of head and neck synovial cell sarcoma". Oncology Letters 9.1 (2015): 381-386.
Chicago
Wushou, A., Miao, X."Tumor size predicts prognosis of head and neck synovial cell sarcoma". Oncology Letters 9, no. 1 (2015): 381-386. https://doi.org/10.3892/ol.2014.2634
Copy and paste a formatted citation
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Spandidos Publications style
Wushou A and Miao XC: Tumor size predicts prognosis of head and neck synovial cell sarcoma. Oncol Lett 9: 381-386, 2015.
APA
Wushou, A., & Miao, X. (2015). Tumor size predicts prognosis of head and neck synovial cell sarcoma. Oncology Letters, 9, 381-386. https://doi.org/10.3892/ol.2014.2634
MLA
Wushou, A., Miao, X."Tumor size predicts prognosis of head and neck synovial cell sarcoma". Oncology Letters 9.1 (2015): 381-386.
Chicago
Wushou, A., Miao, X."Tumor size predicts prognosis of head and neck synovial cell sarcoma". Oncology Letters 9, no. 1 (2015): 381-386. https://doi.org/10.3892/ol.2014.2634
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