Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Oncology Letters
Join Editorial Board Propose a Special Issue
Print ISSN: 1792-1074 Online ISSN: 1792-1082
Journal Cover
January-2015 Volume 9 Issue 1

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
January-2015 Volume 9 Issue 1

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Case Report

Rare incidence of primary adrenocortical carcinosarcoma: A case report and literature review

  • Authors:
    • Yong‑Bao Wei
    • Yun‑Liang Gao
    • Hong‑Tao Wu
    • Shi‑Feng Ou‑Yang
    • Tao Xu
    • Dong‑Fang Mao
    • Jin‑Rui Yang
  • View Affiliations / Copyright

    Affiliations: Department of Urology, The Second Xiangya Hospital, Central South University, Changsha, Hunan 410011, P.R. China
  • Pages: 153-158
    |
    Published online on: October 24, 2014
       https://doi.org/10.3892/ol.2014.2635
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Adrenocortical carcinoma (ACC) is a rare, but highly aggressive type of tumor with an incidence of one to two per million annually. Adrenocortical carcinosarcoma is an exceptional variant of ACC, which is characterized by the presence of histological regions of carcinoma and sarcoma. To date, to the best of our knowledge, there have only been 12 reported cases of adrenocortical carcinosarcoma. In the present study, a case of primary, non‑functional adrenocortical carcinosarcoma is described, as well as a review of the literature to raise awareness of this particularly rare type of malignant neoplasm that is associated with a worse diagnosis and prognosis than adrenocortical carcinoma. In the present study, the patient underwent a laparoscopic left adrenalectomy and the tumor was dissected without complication from the left kidney. Microscopic observations showed the tumor comprised of epithe­lial and spindle cell components. The patient did not exhibit signs of tumor recurrence at the one‑month follow‑up. The potential diagnosis of adrenocortical carcinosarcoma must be considered when diagnosing adrenal malignancies in adults. In addition, comphrensive imunohistochemical staining may be required to identify possible sarcomatous patterns. To the best of our knowledge, the present case is the first to report an incidence of adrenocortical carcinosarcoma in China. Details of the patient are presented and the pathology of adrenocortical carcinosarcoma is discussed.
View Figures

Figure 1

Figure 2

View References

1 

Lacroix A: Approach to the patient with adrenocortical carcinoma. J Clin Endocrinol Metab. 95:4812–4822. 2010. View Article : Google Scholar : PubMed/NCBI

2 

Zini L, Porpiglia F and Fassnacht M: Contemporary management of adrenocortical carcinoma. Eur Urol. 60:1055–1065. 2011. View Article : Google Scholar : PubMed/NCBI

3 

Fassnacht M, Libé R, Kroiss M and Allolio B: Adrenocortical carcinoma: a clinician’s update. Nat Rev Endocrinol. 7:323–335. 2011. View Article : Google Scholar : PubMed/NCBI

4 

Ng L and Libertino JM: Adrenocortical carcinoma: diagnosis, evaluation and treatment. J Urol. 169:5–11. 2003. View Article : Google Scholar

5 

Roman S: Adrenocortical carcinoma. Curr Opin Oncol. 18:36–42. 2006. View Article : Google Scholar

6 

Crucitti F, Bellantone R, Ferrante A, et al: The Italian Registry for Adrenal Cortical Carcinoma: analysis of a multiinstitutional series of 129 patients. The ACC Italian Registry Study Group. Surgery. 119:161–170. 1996. View Article : Google Scholar : PubMed/NCBI

7 

Icard P, Goudet P, Charpenay C, et al: Adrenocortical carcinomas: surgical trends and results of a 253-patient series from the French Association of Endocrine Surgeons study group. World J Surg. 25:891–897. 2001. View Article : Google Scholar : PubMed/NCBI

8 

Tauchmanovà L, Colao A, Marzano LA, et al: Andrenocortical carcinomas: twelve-year prospective experience. World J Surg. 28:896–903. 2004. View Article : Google Scholar : PubMed/NCBI

9 

Decorato JW, Gruber H, Petti M and Levowitz BS: Adrenal carcinosarcoma. J Surg Oncol. 45:134–136. 1990. View Article : Google Scholar : PubMed/NCBI

10 

Fischler DF, Nunez C, Levin HS, et al: Adrenal carcinosarcoma presenting in a woman with clinical signs of virilization. A case report with immunohistochemical and ultrastructural findings. Am J Surg Pathol. 16:626–631. 1992. View Article : Google Scholar : PubMed/NCBI

11 

Sasaki K, Desimone M, Rao HR, et al: Adrenocortical carcinosarcoma: a case report and review of the literature. Diagn Pathol. 5:512010.PubMed/NCBI

12 

Thway K, Olmos D, Shah C, et al: Oncocytic adrenal cortical carcinosarcoma with pleomorphic rhabdomyosarcomatous metastases. Am J Surg Pathol. 36:470–477. 2012. View Article : Google Scholar : PubMed/NCBI

13 

Barksdale SK, Marincola FM and Jaffe G: Carcinosarcoma of the adrenal cortex presenting with mineralocorticoid excess. Am J Surg Pathol. 17:941–945. 1993. View Article : Google Scholar : PubMed/NCBI

14 

Okazumi S, Asano T, Ryu M, et al: Surgical resection of adrenal carcinoma extending into the vena cava, right atrium and ventricle: case report and review of the literature. Nihon Geka Gakkai Zasshi. 88:231–238. 1987.(In Japanese). PubMed/NCBI

15 

Collina G, Maldarizzi F, Betts CM and Eusebi V: Primary sarcomatoid carcinoma of the adrenal gland. First case report. Virchows Arch A Pathol Anat Histopathol. 415:161–167. 1989. View Article : Google Scholar : PubMed/NCBI

16 

Lee MS, Park IA, Chi JG, et al: Adrenal carcinosarcoma - a case report. J Korean Med Sci. 12:374–377. 1997. View Article : Google Scholar : PubMed/NCBI

17 

Sturm N, Moulai N, Laverrière MH, et al: Primary adrenocortical sarcomatoid carcinoma: case report and review of literature. Virchows Arch. 452:215–219. 2008. View Article : Google Scholar

18 

Coli A, Di Giorgio A, Castri F, et al: Sarcomatoid carcinoma of the adrenal gland: a case report and review of literature. Pathol Res Pract. 206:59–65. 2010. View Article : Google Scholar

19 

Bertolini F, Rossi G, Fiocchi F, et al: Primary adrenal gland carcinosarcoma associated with metastatic rectal cancer: a hitherto unreported collision tumor. Tumori. 97:27e–30e. 2011.PubMed/NCBI

20 

Kao CS, Grignon DJ, Ulbright TM and Idrees MT: A case report of adrenocortical carcinosarcoma with oncocytic and primitive neuroectodermal-like features. Hum pathol. 44:1947–1955. 2013. View Article : Google Scholar : PubMed/NCBI

21 

Miettinen M: Neuroendocrine differentiation in adrenocortical carcinoma. New immunohistochemical findings supported by electron microscopy. Lab Invest. 66:169–174. 1992.PubMed/NCBI

22 

Hoang MP, Ayala AG and Albores-Saavedra J: Oncocytic adrenocortical carcinoma: a morphologic, immunohistochemical and ultrastructural study of four cases. Mod Pathol. 15:973–978. 2002. View Article : Google Scholar : PubMed/NCBI

23 

Jorda M, De MB and Nadji M: Calretinin and inhibin are useful in separating adrenocortical neoplasms from pheochromocytomas. Appl Immunohistochem Mol Morphol. 10:67–70. 2002. View Article : Google Scholar : PubMed/NCBI

24 

Ghorab Z, Jorda M, Ganjei P and Nadji M: Melan A (A103) is expressed in adrenocortical neoplasms but not in renal cell and hepatocellular carcinomas. Appl Immunohistochem Mol Morphol. 11:330–333. 2003. View Article : Google Scholar : PubMed/NCBI

25 

Zhang PJ, Genega EM, Tomaszewski JE, et al: The role of calretinin, inhibin, melan-A, BCL-2, and C-kit in differentiating adrenal cortical and medullary tumors: an immunohistochemical study. Mod Pathol. 16:591–597. 2003. View Article : Google Scholar : PubMed/NCBI

26 

Pan CC, Chen PC, Tsay SH and Ho DM: Differential immunoprofiles of hepatocellular carcinoma, renal cell carcinoma, and adrenocortical carcinoma: a systemic immunohistochemical survey using tissue array technique. Appl Immunohistochem Mol Morphol. 13:347–352. 2005. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Wei YB, Gao YL, Wu HT, Ou‑Yang SF, Xu T, Mao DF and Yang JR: Rare incidence of primary adrenocortical carcinosarcoma: A case report and literature review. Oncol Lett 9: 153-158, 2015.
APA
Wei, Y., Gao, Y., Wu, H., Ou‑Yang, S., Xu, T., Mao, D., & Yang, J. (2015). Rare incidence of primary adrenocortical carcinosarcoma: A case report and literature review. Oncology Letters, 9, 153-158. https://doi.org/10.3892/ol.2014.2635
MLA
Wei, Y., Gao, Y., Wu, H., Ou‑Yang, S., Xu, T., Mao, D., Yang, J."Rare incidence of primary adrenocortical carcinosarcoma: A case report and literature review". Oncology Letters 9.1 (2015): 153-158.
Chicago
Wei, Y., Gao, Y., Wu, H., Ou‑Yang, S., Xu, T., Mao, D., Yang, J."Rare incidence of primary adrenocortical carcinosarcoma: A case report and literature review". Oncology Letters 9, no. 1 (2015): 153-158. https://doi.org/10.3892/ol.2014.2635
Copy and paste a formatted citation
x
Spandidos Publications style
Wei YB, Gao YL, Wu HT, Ou‑Yang SF, Xu T, Mao DF and Yang JR: Rare incidence of primary adrenocortical carcinosarcoma: A case report and literature review. Oncol Lett 9: 153-158, 2015.
APA
Wei, Y., Gao, Y., Wu, H., Ou‑Yang, S., Xu, T., Mao, D., & Yang, J. (2015). Rare incidence of primary adrenocortical carcinosarcoma: A case report and literature review. Oncology Letters, 9, 153-158. https://doi.org/10.3892/ol.2014.2635
MLA
Wei, Y., Gao, Y., Wu, H., Ou‑Yang, S., Xu, T., Mao, D., Yang, J."Rare incidence of primary adrenocortical carcinosarcoma: A case report and literature review". Oncology Letters 9.1 (2015): 153-158.
Chicago
Wei, Y., Gao, Y., Wu, H., Ou‑Yang, S., Xu, T., Mao, D., Yang, J."Rare incidence of primary adrenocortical carcinosarcoma: A case report and literature review". Oncology Letters 9, no. 1 (2015): 153-158. https://doi.org/10.3892/ol.2014.2635
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team