Small cell carcinoma of the urinary bladder: A case report and review of the literature

Ou,Wen‑Ting; Liang,Qi‑Lian; Huang,Xin; Li,Zhou‑Yu; Liu,Qiu‑Long

doi:10.3892/ol.2014.2646

January-2015 Volume 9 Issue 1

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January-2015 Volume 9 Issue 1

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Case Report

Small cell carcinoma of the urinary bladder: A case report and review of the literature

Authors:
- Wen‑Ting Ou
- Qi‑Lian Liang
- Xin Huang
- Zhou‑Yu Li
- Qiu‑Long Liu
View Affiliations / Copyright

Affiliations: Department of Oncology, Affiliated Hospital of Guangdong Medical College, Zhanjiang, Guangdong 524001, P.R. China, Department of Radiotherapy, Cancer Center of Guangzhou Medical University, Guangzhou, Guangdong 510095, P.R. China
Pages: 488-490
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Published online on: October 30, 2014

https://doi.org/10.3892/ol.2014.2646
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Abstract

Small cell carcinoma of the urinary bladder (SCBC) is a type of rare malignant tumor of the urinary tract. As it does not have specific symptoms and its epidemiological features are similar to transitional cell carcinoma of the bladder, it is often misdiagnosed. SCBC is highly aggressive, metastasizes very early and has a poor prognosis, and consequently, it has become a focus for urological surgeons and oncologists. An 82‑year‑old male visited the Department of Urinary Surgery, in the Affiliated Hospital of Guangdong Medical College (Zhanjiang, China), due to gross hematuria that had persisted for one week. Abdominal computed tomography showed a neoplasm of ~6x6x7 cm on the anterior wall of the bladder. The initial diagnosis was of uroepithelial cell carcinoma of the bladder and surgery was performed to remove the tumor. However, the subsequent pathological examination suggested that the tumor was an SCBC. Small cell carcinoma is a highly malignant disease, with a high mortality rate, and it rarely occurs in the bladder. Upon review of a large number of studies, SCBC was not found to present with specific symptoms, making the early diagnosis of the disease difficult, however, commonly occurring symptoms included dysuria, painless gross hematuria and urinary tract obstruction.

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1	Riaz SP, Lüchtenborg M, Coupland VH, et al: Trends in incidence of small cell lung cancer and all lung cancer. Lung Cancer. 75:280–284. 2012. View Article : Google Scholar
2	Koga F, Yokoyama M and Fukushima H: Small cell carcinoma of the urinary bladder: a contemporary review with a special focus on bladder-sparing treatments. Expert Rev Anticancer Ther. 13:1269–1279. 2013. View Article : Google Scholar : PubMed/NCBI
3	Cheng L, Jones TD, McCarthy RP, et al: Molecular genetic evidence for a common clonal origin of urinary bladder small cell carcinoma and coexisting urothelial carcinoma. Am J Pathol. 166:1533–1539. 2005. View Article : Google Scholar : PubMed/NCBI
4	Grignon DJ, Ro JY, Ayala AG, et al: Small cell carcinoma of the urinary bladder. A clinicopathologic analysis of 22 cases. Cancer. 69:527–536. 1992. View Article : Google Scholar : PubMed/NCBI
5	Pervez N, El-Gehani F, Joseph K, et al: Genitourinary small-cell carcinoma: a single-institution experience. Curr Oncol. 20:258–264. 2013. View Article : Google Scholar : PubMed/NCBI
6	Gon S, Majumdar B, Dey RK and Mitra SK: Pure primary small cell carcinoma of urinary bladder: A rare diagnostic entity. Urol Ann. 5:209–211. 2013. View Article : Google Scholar : PubMed/NCBI
7	Koay EJ, Teh BS, Paulino AC and Butler EB: A Surveillance, Epidemiology, and End Results analysis of small cell carcinoma of the bladder: epidemiology, prognostic variables, and treatment trends. Cancer. 117:5325–5333. 2011. View Article : Google Scholar : PubMed/NCBI
8	Choong NW, Quevedo JF and Kaur JS: Small cell carcinoma of the urinary bladder. The Mayo Clinic experience. Cancer. 103:1172–1178. 2005. View Article : Google Scholar : PubMed/NCBI
9	Mangar SA, Logue JP, Shanks JH, et al: Small-cell carcinoma of the urinary bladder: 10-year experience. Clin Oncol (R Coll Radiol). 16:523–527. 2004. View Article : Google Scholar
10	Quek ML, Nichols PW, Yamzon J, et al: Radical cystectomy for primary neuroendocrine tumors of the bladder: the University of Southern California experience. J Urol. 174:93–96. 2005. View Article : Google Scholar : PubMed/NCBI
11	Gkirlemis K, Miliadou A, Koukourakis G and Sotiropoulou-Lontou A: Small cell carcinoma of the bladder: a search of the current literature. J BUON. 18:220–226. 2013.PubMed/NCBI
12	Dong WX, Ping YX, Liang WC, et al: Small cell carcinoma of the urinary bladder diverticulum: a case report and review of the literature. J Cancer Res Ther. 9:151–153. 2013. View Article : Google Scholar : PubMed/NCBI
13	Siefker-Radtke AO, Dinney CP, Abrahams NA, et al: Evidence supporting preoperative chemotherapy for small cell carcinoma of the bladder: a retrospective review of the M. D. Anderson cancer experience. J Urol. 172:481–484. 2004. View Article : Google Scholar : PubMed/NCBI
14	Sejima T and Miyagawa I: ‘Successful’ chemo- and radiotherapy prior to radical cystectomy does not necessarily correlate with clinical course in small cell carcinoma of the bladder. Urol Int. 74:286–288. 2005. View Article : Google Scholar
15	Nejat RJ, Purohit R, Goluboff ET, et al: Cure of undifferentiated small cell carcinoma of the urinary bladder with M-VAC chemotherapy. Urologic Oncology. 6:53–55. 2001. View Article : Google Scholar : PubMed/NCBI
16	Bastús R, Caballero JM, González G, et al: Small cell carcinoma of the urinary bladder treated with chemotherapy and radiotherapy: results in five cases. Eur Urol. 35:323–326. 1999. View Article : Google Scholar : PubMed/NCBI

Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Small cell carcinoma of the urinary bladder: A case report and review of the literature

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