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Print ISSN: 1792-1074 Online ISSN: 1792-1082
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January-2015 Volume 9 Issue 1

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Case Report

Salivary duct carcinoma of the parotid gland: A case report and review of the literature

  • Authors:
    • Shule Xie
    • Hongyu Yang
    • Marius Bredell
    • Shiyue Shen
    • Huijun Yang
    • Long Jin
    • Shanshan Zhang

  • View Affiliations / Copyright

    Affiliations: Department of Oral and Maxillofacial Surgery, Peking University Shenzhen Hospital, Shenzhen, Guangdong 518001, P.R. China, Department of Cranio-maxillofacial and Oral Surgery, University Hospital Zürich, Zurich 8091, Switzerland
  • Pages: 371-374
    |
    Published online on: October 31, 2014
       https://doi.org/10.3892/ol.2014.2655
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Abstract

Salivary duct carcinoma (SDC) is a rare and aggressive parotid malignancy that most commonly affects males in the fifth and sixth decades of life. Histopathology specimens obtained from SDC patients demonstrate a resemblance to ductal carcinoma of the breast. Therefore, to distinguish SDC from breast ductal carcinoma, several immunohistochemical markers exist that may enable surgeons to make an accurate diagnosis. In this study, the case of a 54-year-old male with salivary duct carcinoma of the right parotid gland is presented. The results of the present case study revealed that the SDC sample was positive for the expression of human epidermal growth factor 2 (Her‑2), cytokeratin (CK) 8/CK 18, p63, high molecular weight CK and calponin, and negative for expression of the estrogen receptor and progesterone receptor. Based on the result, an ipsilateral selective neck dissection followed by adjuvant post‑operative radiation therapy was suitable at the primary treatment stage. At one year of follow-up, the patient was alive and free of recurrence. In advanced cases of SDC, treatment with anti‑HER‑2 monoclonal antibodies, such as trastuzumab, is recommended.
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Copy and paste a formatted citation
Spandidos Publications style
Xie S, Yang H, Bredell M, Shen S, Yang H, Jin L and Zhang S: Salivary duct carcinoma of the parotid gland: A case report and review of the literature. Oncol Lett 9: 371-374, 2015.
APA
Xie, S., Yang, H., Bredell, M., Shen, S., Yang, H., Jin, L., & Zhang, S. (2015). Salivary duct carcinoma of the parotid gland: A case report and review of the literature. Oncology Letters, 9, 371-374. https://doi.org/10.3892/ol.2014.2655
MLA
Xie, S., Yang, H., Bredell, M., Shen, S., Yang, H., Jin, L., Zhang, S."Salivary duct carcinoma of the parotid gland: A case report and review of the literature". Oncology Letters 9.1 (2015): 371-374.
Chicago
Xie, S., Yang, H., Bredell, M., Shen, S., Yang, H., Jin, L., Zhang, S."Salivary duct carcinoma of the parotid gland: A case report and review of the literature". Oncology Letters 9, no. 1 (2015): 371-374. https://doi.org/10.3892/ol.2014.2655
Copy and paste a formatted citation
x
Spandidos Publications style
Xie S, Yang H, Bredell M, Shen S, Yang H, Jin L and Zhang S: Salivary duct carcinoma of the parotid gland: A case report and review of the literature. Oncol Lett 9: 371-374, 2015.
APA
Xie, S., Yang, H., Bredell, M., Shen, S., Yang, H., Jin, L., & Zhang, S. (2015). Salivary duct carcinoma of the parotid gland: A case report and review of the literature. Oncology Letters, 9, 371-374. https://doi.org/10.3892/ol.2014.2655
MLA
Xie, S., Yang, H., Bredell, M., Shen, S., Yang, H., Jin, L., Zhang, S."Salivary duct carcinoma of the parotid gland: A case report and review of the literature". Oncology Letters 9.1 (2015): 371-374.
Chicago
Xie, S., Yang, H., Bredell, M., Shen, S., Yang, H., Jin, L., Zhang, S."Salivary duct carcinoma of the parotid gland: A case report and review of the literature". Oncology Letters 9, no. 1 (2015): 371-374. https://doi.org/10.3892/ol.2014.2655
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