Peripheral T‑cell lymphoma with hypercalcemic crisis as a primary symptom accompanied by polymyositis: A case report and review of the literature

Ding,Luyin; Xiao,Xibin; Huang,Liansheng

doi:10.3892/ol.2014.2661

January-2015 Volume 9 Issue 1

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January-2015 Volume 9 Issue 1

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Case Report

Peripheral T‑cell lymphoma with hypercalcemic crisis as a primary symptom accompanied by polymyositis: A case report and review of the literature

Authors:
- Luyin Ding
- Xibin Xiao
- Liansheng Huang
View Affiliations / Copyright

Affiliations: Department of Hematology, The Second Affiliated Hospital of Zhejiang University Medical College, Hangzhou, Zhejiang 310009, P.R. China
Pages: 231-234
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Published online on: November 3, 2014

https://doi.org/10.3892/ol.2014.2661
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Abstract

The present study reports the case of a 61‑year‑old male with polymyositis who presented with exacerbated weakness in the lower limbs and a recurrent fever that had persisted for one month. Positron emission tomography/computed tomography scans revealed multiple regions of elevated fluorodeoxyglucose metabolism in the lymph nodes, lungs, liver, spleen and bones. While symptoms of nonchalance and confusion were identified on admission, the patient's serum calcium level was high at 3.87 mmol/l, so a hypercalcemic crisis was confirmed. A biopsy of the right lingual lymph node revealed peripheral T‑cell lymphoma, not otherwise specified. The serum calcium level was restored to within the normal range following emergency measures, such as saline rehydration, diuretics, calcitonin and glucocorticoids, and partial remission was achieved following two courses of chemotherapy. The study may improve our present understanding of the diagnosis and treatment of cancer‑associated myositis (CAM) and malignancy‑associated hypercalcemia.

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1	Hak AE, de Paepe B, de Bleecker JL, Tak PP and de Visser M: Dermatomyositis and polymyositis: new treatment targets on the horizon. Neth J Med. 69:410–421. 2011.PubMed/NCBI
2	Buchbinder R and Hill CL: Malignancy in patients with inflammatory myopathy. Curr Rheumatol Rep. 4:415–426. 2002. View Article : Google Scholar : PubMed/NCBI
3	Savage KJ, Chhanabhai M, Gascoyne RD and Connors JM: Characterization of peripheral T-cell lymphomas in a single North American institution by the WHO classification. Ann Oncol. 15:1467–1475. 2004. View Article : Google Scholar : PubMed/NCBI
4	Sargent JT and Smith OP: Haematological emergencies managing hypercalcaemia in adults and children with haematological disorders. Br J Haematol. 149:465–477. 2010. View Article : Google Scholar : PubMed/NCBI
5	Shepard MM and Smith JW III: Hypercalcemia. Am J Med Sci. 334:381–385. 2007. View Article : Google Scholar : PubMed/NCBI
6	Dyck PJ, Boes CJ, Mulder D, Millikan C, Windebank AJ, Dyck PJ and Espinosa R: History of standard scoring, notation, and summation of neuromuscular signs. A current survey and recommendation. J Peripher Nerv Syst. 10:158–173. 2005. View Article : Google Scholar : PubMed/NCBI
7	Lister TA, Crowther D, Sutcliffe SB, et al: Report of a committee convened to discuss the evaluation and staging of patients with Hodgkin’s disease: Cotswolds meeting. J Clin Oncol. 7:1630–1636. 1989.PubMed/NCBI
8	Hill CL, Zhang Y, Sigurgeirsson B, et al: Frequency of specific cancer types in dermatomyositis and polymyositis: a population-based study. Lancet. 357:96–100. 2001. View Article : Google Scholar : PubMed/NCBI
9	Aggarwal R and Oddis CV: Paraneoplastic myalgias and myositis. Rheum Dis Clin North Am. 37:607–621. 2011. View Article : Google Scholar : PubMed/NCBI
10	Chen YJ, Wu CY, Huang YL, Wang CB, Shen JL and Chang YT: Cancer risks of dermatomyositis and polymyositis: a nationwide cohort study in Taiwan. Arthritis Res Ther. 12:R702010. View Article : Google Scholar : PubMed/NCBI
11	Selva-O’Callaghan A, Grau JM, Gámez-Cenzano C, et al: Conventional cancer screening versus PET/CT in dermatomyositis/polymyositis. Am J Med. 123:558–562. 2010. View Article : Google Scholar
12	Endres DB: Investigation of hypercalcemia. Clin Biochem. 45:954–963. 2012. View Article : Google Scholar : PubMed/NCBI
13	Vassilopoulou-Sellin R, Newman BM, Taylor SH and Guinee VF: Incidence of hypercalcemia in patients with malignancy referred to a comprehensive cancer center. Cancer. 71:1309–1312. 1993. View Article : Google Scholar : PubMed/NCBI
14	Clines GA and Guise TA: Hypercalcaemia of malignancy and basic research on mechanisms responsible for osteolytic and osteoblastic metastasis to bone. Endocr Relat Cancer. 12:549–583. 2005. View Article : Google Scholar : PubMed/NCBI
15	Majumdar G: Incidence and prognostic significance of hypercalcaemia in B-cell non-Hodgkin’s lymphoma. J Clin Pathol. 55:637–638. 2002. View Article : Google Scholar : PubMed/NCBI
16	Hewison M, Kantorovich V, Liker HR, et al: Vitamin D-mediated hypercalcemia in lymphoma: evidence for hormone production by tumor-adjacent macrophages. J Bone Miner Res. 18:579–582. 2003. View Article : Google Scholar : PubMed/NCBI
17	No authors listed. A predictive model for aggressive non-Hodgkin’s lymphoma. The International Non-Hodgkin’s Lymphoma Prognostic Factors Project. N Engl J Med. 329:987–994. 1993. View Article : Google Scholar
18	Koh LK: The diagnosis and management of hypercalcaemia. Ann Acad Med Singapore. 32:129–139. 2003.PubMed/NCBI

Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Peripheral T‑cell lymphoma with hypercalcemic crisis as a primary symptom accompanied by polymyositis: A case report and review of the literature

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