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Article

Pre‑operative granulocyte/lymphocyte ratio as a predictive marker of post‑operative complications in patients with colorectal cancer

  • Authors:
    • Jiro Shimazaki
    • Takanobu Tabuchi
    • Takeshi Nakachi
    • Gyo Motohashi
    • Kiyotaka Nishida
    • Hideyuki Ubukata
    • Takafumi Tabuchi
  • View Affiliations / Copyright

    Affiliations: Department of Gastrointestinal Surgery, Ibaraki Medical Center, Tokyo Medical University, Ami, Ibaraki 300‑0395, Japan
  • Pages: 425-429
    |
    Published online on: November 4, 2014
       https://doi.org/10.3892/ol.2014.2669
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Abstract

The aim of the present study was to assess the clinical relevance of the pre‑operative granulocyte/lymphocyte (G/L) ratio as a predictive marker of post‑operative complications in patients with colorectal cancer. In total, 85 patients (59 males and 26 females; mean age, 68.9 years) underwent surgery for colorectal cancer at the Department of Surgery, Ibraki Medical Center, Tokyo Medical University (Ami, Japan), and were divided into post‑operative complication and non‑complication groups. Clinical data, including age, gender, body mass index, tumor localization, tumor pathological type, cancer staging, surgery time, volume of surgical bleeding, pre‑operative G/L ratio and further pre‑operative laboratory data, including levels of albumin and C‑reactive protein, Glasgow Prognostic Score, white blood cell count and levels of hemoglobin, creatine kinase, lactate dehydrogenase, carcinoembryonic antigen and carbohydrate antigen 19‑9 were analyzed between these groups. The total post‑operative complication rate was 18.8%. On univariate analysis, the amount of surgical bleeding and the pre‑operative G/L ratio were significantly higher in the complication group than in the non‑complication group (299.8±361.7 vs. 155.6±268.6 ml, P<0.05; and 6.73±10.38 vs. 3.49±2.78, P<0.05, respectively). Multivariate logistic regression analysis for the risk factors of post‑operative complications, determined using univariate analysis, demonstrated that the amount of surgical bleeding and the pre‑operative G/L ratio were independent risk factors of post‑operative complications in patients with colorectal cancer. In conclusion, the G/L ratio may be a clinically relevant pre‑operative predictive marker for post‑operative complications.
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Copy and paste a formatted citation
Spandidos Publications style
Shimazaki J, Tabuchi T, Nakachi T, Motohashi G, Nishida K, Ubukata H and Tabuchi T: Pre‑operative granulocyte/lymphocyte ratio as a predictive marker of post‑operative complications in patients with colorectal cancer. Oncol Lett 9: 425-429, 2015.
APA
Shimazaki, J., Tabuchi, T., Nakachi, T., Motohashi, G., Nishida, K., Ubukata, H., & Tabuchi, T. (2015). Pre‑operative granulocyte/lymphocyte ratio as a predictive marker of post‑operative complications in patients with colorectal cancer. Oncology Letters, 9, 425-429. https://doi.org/10.3892/ol.2014.2669
MLA
Shimazaki, J., Tabuchi, T., Nakachi, T., Motohashi, G., Nishida, K., Ubukata, H., Tabuchi, T."Pre‑operative granulocyte/lymphocyte ratio as a predictive marker of post‑operative complications in patients with colorectal cancer". Oncology Letters 9.1 (2015): 425-429.
Chicago
Shimazaki, J., Tabuchi, T., Nakachi, T., Motohashi, G., Nishida, K., Ubukata, H., Tabuchi, T."Pre‑operative granulocyte/lymphocyte ratio as a predictive marker of post‑operative complications in patients with colorectal cancer". Oncology Letters 9, no. 1 (2015): 425-429. https://doi.org/10.3892/ol.2014.2669
Copy and paste a formatted citation
x
Spandidos Publications style
Shimazaki J, Tabuchi T, Nakachi T, Motohashi G, Nishida K, Ubukata H and Tabuchi T: Pre‑operative granulocyte/lymphocyte ratio as a predictive marker of post‑operative complications in patients with colorectal cancer. Oncol Lett 9: 425-429, 2015.
APA
Shimazaki, J., Tabuchi, T., Nakachi, T., Motohashi, G., Nishida, K., Ubukata, H., & Tabuchi, T. (2015). Pre‑operative granulocyte/lymphocyte ratio as a predictive marker of post‑operative complications in patients with colorectal cancer. Oncology Letters, 9, 425-429. https://doi.org/10.3892/ol.2014.2669
MLA
Shimazaki, J., Tabuchi, T., Nakachi, T., Motohashi, G., Nishida, K., Ubukata, H., Tabuchi, T."Pre‑operative granulocyte/lymphocyte ratio as a predictive marker of post‑operative complications in patients with colorectal cancer". Oncology Letters 9.1 (2015): 425-429.
Chicago
Shimazaki, J., Tabuchi, T., Nakachi, T., Motohashi, G., Nishida, K., Ubukata, H., Tabuchi, T."Pre‑operative granulocyte/lymphocyte ratio as a predictive marker of post‑operative complications in patients with colorectal cancer". Oncology Letters 9, no. 1 (2015): 425-429. https://doi.org/10.3892/ol.2014.2669
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