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Article

A phase I clinical trial of dose escalation of lobaplatin in combination with fixed‑dose docetaxel for the treatment of human solid tumours that had progressed following chemotherapy

  • Authors:
    • Yu Peng
    • Yue‑E Liu
    • Xiao‑Can Ren
    • Xue‑Ji Chen
    • Hui‑Ling Su
    • Jie Zong
    • Zeng‑Li Feng
    • Dong‑Ying Wang
    • Qiang Lin
    • Xian‑Shu Gao
  • View Affiliations / Copyright

    Affiliations: Hebei North University, Zhangjiakou, Hebei 075000, P.R. China, Department of Oncology, North China Petroleum Bureau General Hospital of Hebei Medical University, Renqiu, Hebei 062552, P.R. China, Department of Radiation Oncology, Peking University First Hospital, Xicheng, Beijing 100034, P.R. China
  • Pages: 67-74
    |
    Published online on: November 5, 2014
       https://doi.org/10.3892/ol.2014.2675
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Abstract

In this study, the maximum tolerated dose (MTD) of lobaplatin (LBP) when it was combined with docetaxel (TXT) for the treatment of solid tumours that had progressed following chemotherapy was determined, and toxicities to this regimen were evaluated. A modified Fibonacci method was used for the dose escalation of LBP. The patients received TXT (at a fixed dose of 60 mg/m2) on day one (d1) and LBP (at an initial tested dose of 30 mg/m2) on day two (d2) of a treatment cycle that was repeated every 21 days. Each dose group consisted of at least three cases. In the absence of dose‑limiting toxicity (DLT), we proceeded to the next dose group, with a dose increment of 5 mg/m2 between groups, until DLT occurred. The dose immediately below the dose that produced DLT was regarded as the MTD. The 17 patients examined in this study completed a total of 58 cycles of chemotherapy, and a total of three dose‑escalation groups (30 mg/m2 LBP, 35 mg/m2 LBP, and 40 mg/m2 LBP) were established. The main adverse event that was observed was myelosuppression. DLT occurred in four patients, including three patients in the 40 mg/m2 LBP group and one patient in the 35 mg/m2 LBP group. In total, three out of the four patients in the 40 mg/m2 LBP group exhibited DLT. We determined that the treatment administered to the 35 mg/m2 LBP group represented the MTD. Thus, our phase I trial revealed that the MTD for the tested LBP combination regimen was 35 mg/m2 LBP and 60 mg/m2 TXT. This regimen resulted in mild adverse reactions and favourable patient tolerance. Therefore, we recommend the use of these dosages in phase II clinical trials.
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1 

Chen WQ, Zheng RS, Zeng HM, Zhang SW, Li N, Zou XN and He J: Trend analysis and prediction of cancer incidence in China. Zhonghua Yu Fang Yi Xue Za Zhi. 46:581–586. 2012.(In Chinese). PubMed/NCBI

2 

Harstrick A, Bokemeyer C, Scharnofkse M, Hapke G, Reile D and Schmoll HJ: Preclinical activity of a new platinum analogue, lobaplatin, in cisplatin-sensitive and -resistant human testicular, ovarian, and gastric carcinoma cell lines. Cancer Chemother Pharmacol. 33:43–47. 1993. View Article : Google Scholar : PubMed/NCBI

3 

Gietema JA, Guchelaar HJ, de Vries EG, Aulenbacher P, Sleijfer DT and Mulder NH: A Phase I study of lobaplatin (D-19466) administered by 72 h continuous infusion. Anticancer Drugs. 4:51–55. 1993. View Article : Google Scholar : PubMed/NCBI

4 

Lai SQ and Xu M: Antineoplastic-lobaplatin. Shi Jie Lin Chuang Yao Wu. 26:3152005.(In Chinese).

5 

Yang LQ and Qin SK: Progression of lobaplatin as the third generation platinum drug. Lin Chuang Zhong Liu Xue Za Zhi. 14:1134–1139. 2009.(In Chinese).

6 

Mckeage MJ: Lobaplatin: a new antitumor platinum drug. Expert Opin Investig Drugs. 10:119–128. 2001. View Article : Google Scholar

7 

Saris CP, van De Vaart PJ, Rietbroek RC and Blommaert FA: In Vitro formation of DNA adducts by cisplatin, lobaplatin and oxaliplatin in calf thymus DNA in solution and in cultured human cells. Carcinogenesis. 17:2763–2769. 1996. View Article : Google Scholar : PubMed/NCBI

8 

Shi J, Yuan ZF, Liu WN, et al: Study on Lobaplatin Pharmacokinetic in Human Plasma and Tumor Tissue of Malignant Patients. Zhongguo Yaoxue Zazhi. 24:1888–1891. 2007.(In Chinese).

9 

Welink J, Pechstein B and van der Vijgh WJ: Determination of the two diastereoisomers of lobaplatin (D-19466) in plasma ultrafiltrate of cancer patients with a normal or an impaired kidney or liver function by high-performance liquid chromatography with ultraviolet detection. J Chromatogr B Biomed Appl. 675:107–111. 1996. View Article : Google Scholar : PubMed/NCBI

10 

Deng QQ, Huang XE, Ye LH, Lu YY, Liang Y and Xiang J: Phase II trial of Loubo® (Lobaplatin) and pemetrexed for patients with metastatic breast cancer not responding to anthracycline or taxanes. Asian Pac J Cancer Prev. 14:413–417. 2013. View Article : Google Scholar

11 

Xie CY, Xu YP, Jin W and Lou LG: Antitumor activity of lobaplatin alone or in combination with antitubulin agents in non-small-cell lung cancer. Anticancer Drugs. 23:698–705. 2012. View Article : Google Scholar : PubMed/NCBI

12 

Zhang Y, Liu YG and Sun H: Clinical observation of docetaxel plus lobaplatin in treating anthracyclines resistant advanced breast cancer. Xian Dai Zhong Liu Xue Za Zhi. 3:473–474. 2011.(In Chinese).

13 

Chouaid C, Atsou K, Hejblum G and Vergnenegre A: Economics of treatments for non-small cell lung cancer. Pharmacoeconomics. 27:113–125. 2009. View Article : Google Scholar : PubMed/NCBI

14 

Dancey J, Shepherd FA, Gralla RJ and Kim YS: Quality of life assessment of second-line docetaxel versus best supportive care in patients with non-small-cell lung cancer previously treated with platinum-based chemotherapy: results of a prospective, randomized phase III trial. Lung Cancer. 43:183–194. 2004. View Article : Google Scholar : PubMed/NCBI

15 

Davies AM, Lara PN Jr, Mack PC and Gandara DR: Docetaxel in non-small cell lung cancer: a review. Expert Opin Pharmacother. 4:553–565. 2003. View Article : Google Scholar : PubMed/NCBI

16 

Nabholtz JM and Crown J: Phase III studies of single-agent docetaxel in patients with metastatic breast cancer who have progressed despite previous chemotherapy regimens: preliminary results. Semin Oncol. 25:4–9. 1998.PubMed/NCBI

17 

Fiebig HH, Henß H, Mross K, et al: Phase I clinical trial of lobaplatin (D-19466) after intravenous bolus injection. Onkologie. 17:142–148. 1994. View Article : Google Scholar

18 

Manegold C, Drings P, Gatzemeier U, Pawel Jv, Fiebig HH, Queißer W and Edler L: Lobaplatin (D-19466) in Patients with Advanced Non-Small-Cell Lung Cancer: A Trial of the Association for Medical Oncology (AIO) Phase II Study Group. Onkologie. 19:248–251. 1996. View Article : Google Scholar

19 

Degardin M, Armand JP, Chevallier B, Cappelaere P, Lentz MA, David M and Roché H: A clinical screening cooperative group phase II evaluation of lobaplatin (ASTA D-19466) in advanced head and neck cancer. Invest New Drugs. 13:253–255. 1995. View Article : Google Scholar : PubMed/NCBI

20 

Kavanagh JJ, Edwards CL, Freedman RS, et al: A trial of lobaplatin (D-19466) in platinum-resistant ovarian cancer. Gynecol Oncol. 58:106–109. 1995. View Article : Google Scholar : PubMed/NCBI

21 

Huisman C, Smit EF, Giaccone G and Postmus PE: Second-line chemotherapy in relapsing or refractory non-small-cell lung cancer: a review. J Clin Oncol. 18:3722–3730. 2000.PubMed/NCBI

22 

Lai CL, Tsai CM, Chiu CH, Wang GS, Su WJ, Chen YM and Perng RP: Phase II randomized trial of tri-weekly versus days 1 and 8 weekly docetaxel as a second-line treatment of advanced non-small cell lung cancer. Jpn J Clin Oncol. 35:700–706. 2005. View Article : Google Scholar : PubMed/NCBI

23 

Kunitoh H, Watanabe K, Onoshi T, Furuse K, Niitani H and Taguchi T: Phase II trial of docetaxel in previously untreated advanced non-small-cell lung cancer: a Japanese cooperativestudy. J Clin Oncol. 14:1649–1655. 1996.PubMed/NCBI

24 

Nakamura Y, Kunitoh H, Kubota K, Sekine I, Yamamoto N, Tamura T, et al: Retrospective analysis of safety and efficacy of low-dose docetaxel 60 mg/m2 in advanced non-small cell lung cancer patients previously treated with platinum-based chemotherapy. Am J Clin Oncol. 26:459–464. 2003. View Article : Google Scholar : PubMed/NCBI

25 

Lin Q, Gao XS, Qiao XY, et al: Phase I trial of escalating-dose cisplatin with 5-fluorouracil and concurrent radiotherapy in Chinese patients with esophageal cancer. Acta Med Okayama. 62:37–44. 2008.PubMed/NCBI

26 

Lin Q, Liu YE, Chang CL, et al: Phase I trial of dose escalation of capecitabine combined with fixed docetaxel in previously treated patients with non-small cell lung cancer. Chinese-German Journal of Clinical Oncology. 11:6–10. 2012. View Article : Google Scholar

27 

Ardizzoni A, Tiseo M, Boni L, et al: Pemetrexed versus pemetrexed and carboplatin as second-line chemotherapy in advanced non-small-cell lung cancer: results of the GOIRC 02-2006 randomized phase II study and pooled analysis with the NVALT7 trial. J Clin Oncol. 30:4501–4507. PubMed/NCBI

28 

Kim HJ, Yun J, Kim HJ, et al: Phase II study of palliative S-1 in combination with cisplatin as second-line chemotherapy for gemcitabine-refractory pancreatic cancer patients. Oncol Lett. 3:1314–1318. PubMed/NCBI

29 

DCTD, NCI, NIH and DHHS. Cancer Therapy Evaluation Program, Common Toxicity Criteria for Adverse Events, Version 3.0. http://ctep.cancer.gov/protocolDevelopment/electronic_applications/docs/ctcaev3.pdf. Accessed October 30, 2014

30 

Ratain MJ, Mick R, Schilsky RL and Siegler M: Statistical and ethical issues in the design and conduct of phase I and II clinical trials of new anticancer agents. J Natl Cancer Inst. 85:1637–1643. 1993. View Article : Google Scholar : PubMed/NCBI

31 

Eisenhauer EA, Therasse P, Bogaerts J, et al: New response evaluation criteria in solid tumours: revised RECIST guideline (version 1.1). Eur J Cancer. 45:228–247. 2009. View Article : Google Scholar

32 

Cho KH, Ahn SJ, Pyo HR, et al: A Phase II study of synchronous three-dimensional conformal boost to the gross tumor volume for patients with unresectable Stage III non-small-cell lung cancer: results of Korean Radiation Oncology Group 0301 study. Int J Radiat Oncol Biol Phys. 74:1397–1404. 2009. View Article : Google Scholar : PubMed/NCBI

33 

Ali I, Wani WA, Saleem K and Haque A: Platinum compounds: a hope for future cancer chemotherapy. Anticancer Agents in Med Chem. 13:296–306. 2013. View Article : Google Scholar

34 

Wheate NJ, Walker S, Craig GE and Oun R: The status of platinum anticancer drugs in the clinic and in clinical trials. Dalton Trans. 39:8113–8127. 2010. View Article : Google Scholar : PubMed/NCBI

35 

Cortes JE and Pazdur R: Docetaxel. J Clin Oncol. 13:2643–2655. 1995.PubMed/NCBI

36 

Yang LQ, Shi Y, Qin SK, et al: Clinical study of Lobaplatin combined with Navelbine for advanced non-small cell lung cancer. Lin Chuang Zhong Liu Xue Za Zhi. 12:890–894. 2006.(In Chinese).

37 

He AB, Luo YX, Wang Q, Tong WX and Liu AH: The efficacy of lobaplatin combined with docetaxel versus docetaxel alone as the second-line treatment for advanced non-small cell lung cancer. Lin Chuang Zhong Liu Xue Za Zhi. 10:923–926. 2012.(In Chinese).

38 

Weiss JM and Stinchcombe TE: Second-Line Therapy for Advanced NSCLC. Oncologist. 18:947–953. 2013. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Peng Y, Liu YE, Ren XC, Chen XJ, Su HL, Zong J, Feng ZL, Wang DY, Lin Q, Gao XS, Gao XS, et al: A phase I clinical trial of dose escalation of lobaplatin in combination with fixed‑dose docetaxel for the treatment of human solid tumours that had progressed following chemotherapy. Oncol Lett 9: 67-74, 2015.
APA
Peng, Y., Liu, Y., Ren, X., Chen, X., Su, H., Zong, J. ... Gao, X. (2015). A phase I clinical trial of dose escalation of lobaplatin in combination with fixed‑dose docetaxel for the treatment of human solid tumours that had progressed following chemotherapy. Oncology Letters, 9, 67-74. https://doi.org/10.3892/ol.2014.2675
MLA
Peng, Y., Liu, Y., Ren, X., Chen, X., Su, H., Zong, J., Feng, Z., Wang, D., Lin, Q., Gao, X."A phase I clinical trial of dose escalation of lobaplatin in combination with fixed‑dose docetaxel for the treatment of human solid tumours that had progressed following chemotherapy". Oncology Letters 9.1 (2015): 67-74.
Chicago
Peng, Y., Liu, Y., Ren, X., Chen, X., Su, H., Zong, J., Feng, Z., Wang, D., Lin, Q., Gao, X."A phase I clinical trial of dose escalation of lobaplatin in combination with fixed‑dose docetaxel for the treatment of human solid tumours that had progressed following chemotherapy". Oncology Letters 9, no. 1 (2015): 67-74. https://doi.org/10.3892/ol.2014.2675
Copy and paste a formatted citation
x
Spandidos Publications style
Peng Y, Liu YE, Ren XC, Chen XJ, Su HL, Zong J, Feng ZL, Wang DY, Lin Q, Gao XS, Gao XS, et al: A phase I clinical trial of dose escalation of lobaplatin in combination with fixed‑dose docetaxel for the treatment of human solid tumours that had progressed following chemotherapy. Oncol Lett 9: 67-74, 2015.
APA
Peng, Y., Liu, Y., Ren, X., Chen, X., Su, H., Zong, J. ... Gao, X. (2015). A phase I clinical trial of dose escalation of lobaplatin in combination with fixed‑dose docetaxel for the treatment of human solid tumours that had progressed following chemotherapy. Oncology Letters, 9, 67-74. https://doi.org/10.3892/ol.2014.2675
MLA
Peng, Y., Liu, Y., Ren, X., Chen, X., Su, H., Zong, J., Feng, Z., Wang, D., Lin, Q., Gao, X."A phase I clinical trial of dose escalation of lobaplatin in combination with fixed‑dose docetaxel for the treatment of human solid tumours that had progressed following chemotherapy". Oncology Letters 9.1 (2015): 67-74.
Chicago
Peng, Y., Liu, Y., Ren, X., Chen, X., Su, H., Zong, J., Feng, Z., Wang, D., Lin, Q., Gao, X."A phase I clinical trial of dose escalation of lobaplatin in combination with fixed‑dose docetaxel for the treatment of human solid tumours that had progressed following chemotherapy". Oncology Letters 9, no. 1 (2015): 67-74. https://doi.org/10.3892/ol.2014.2675
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