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Article

Bisdemethoxycurcumin attenuates gastric adenocarcinoma growth by inducing mitochondrial dysfunction

  • Authors:
    • Changjiang Luo
    • Zhixing Du
    • Xing Wei
    • Gang Chen
    • Zhongxue Fu
  • View Affiliations / Copyright

    Affiliations: Department of Gastrointestinal Surgery, The First Affiliated Hospital, Chongqing Medical University, Chongqing 400016, P.R. China, Department of General Surgery, Lanzhou University Second Hospital, Lanzhou, Gansu 730030, P.R. China, Department of Surgical ICU, Lanzhou University Second Hospital, Lanzhou, Gansu 730030, P.R. China
  • Pages: 270-274
    |
    Published online on: November 7, 2014
       https://doi.org/10.3892/ol.2014.2685
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Abstract

Bisdemethoxycurcumin (BDMC) is a demethoxy derivative of curcumin. In this study, a human gastric adenocarcinoma xenograft model was generated in vivo using nude mice and BDMC was observed to suppress the growth and activity of tumors, in addition to improving the physical and mental capacity of the mice. An increased number of apoptotic cells, decreased ratio of B‑cell lymphoma 2 (Bcl‑2)/Bcl‑2‑associated X protein and increased caspase‑3 expression was also observed following treatment with BDMC, indicating that BDMC may promote apoptosis in tumors via mitochondrial modulation. The growth of SGC 7901 gastric cancer cells was inhibited and arrested at G1 phase. Specific indicators of mitochondrial dysfunction, a reduction in adenosine triphosphate generation, the inner mitochondrial membrane potential, augmentation of reactive oxygen species production and cytochrome c were also detected in the mitochondria following treatment with BDMC. These results indicate that BDMC attenuates gastric adenocarcinoma growth by inducing mitochondrial dysfunction.
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Copy and paste a formatted citation
Spandidos Publications style
Luo C, Du Z, Wei X, Chen G and Fu Z: Bisdemethoxycurcumin attenuates gastric adenocarcinoma growth by inducing mitochondrial dysfunction. Oncol Lett 9: 270-274, 2015.
APA
Luo, C., Du, Z., Wei, X., Chen, G., & Fu, Z. (2015). Bisdemethoxycurcumin attenuates gastric adenocarcinoma growth by inducing mitochondrial dysfunction. Oncology Letters, 9, 270-274. https://doi.org/10.3892/ol.2014.2685
MLA
Luo, C., Du, Z., Wei, X., Chen, G., Fu, Z."Bisdemethoxycurcumin attenuates gastric adenocarcinoma growth by inducing mitochondrial dysfunction". Oncology Letters 9.1 (2015): 270-274.
Chicago
Luo, C., Du, Z., Wei, X., Chen, G., Fu, Z."Bisdemethoxycurcumin attenuates gastric adenocarcinoma growth by inducing mitochondrial dysfunction". Oncology Letters 9, no. 1 (2015): 270-274. https://doi.org/10.3892/ol.2014.2685
Copy and paste a formatted citation
x
Spandidos Publications style
Luo C, Du Z, Wei X, Chen G and Fu Z: Bisdemethoxycurcumin attenuates gastric adenocarcinoma growth by inducing mitochondrial dysfunction. Oncol Lett 9: 270-274, 2015.
APA
Luo, C., Du, Z., Wei, X., Chen, G., & Fu, Z. (2015). Bisdemethoxycurcumin attenuates gastric adenocarcinoma growth by inducing mitochondrial dysfunction. Oncology Letters, 9, 270-274. https://doi.org/10.3892/ol.2014.2685
MLA
Luo, C., Du, Z., Wei, X., Chen, G., Fu, Z."Bisdemethoxycurcumin attenuates gastric adenocarcinoma growth by inducing mitochondrial dysfunction". Oncology Letters 9.1 (2015): 270-274.
Chicago
Luo, C., Du, Z., Wei, X., Chen, G., Fu, Z."Bisdemethoxycurcumin attenuates gastric adenocarcinoma growth by inducing mitochondrial dysfunction". Oncology Letters 9, no. 1 (2015): 270-274. https://doi.org/10.3892/ol.2014.2685
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