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Print ISSN: 1792-1074 Online ISSN: 1792-1082
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International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

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International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

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Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

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Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

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Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

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Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

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Article

Lesion human leukocyte antigen‑F expression is associated with a poor prognosis in patients with hepatocellular carcinoma

  • Authors:
    • Yongfu Xu
    • Haixiong Han
    • Fabiao Zhang
    • Shangdong Lv
    • Zhengyu Li
    • Zheping Fang
  • View Affiliations / Copyright

    Affiliations: Department of Hepatobiliary Surgery, Taizhou Hospital of Zhejiang Province, Wenzhou Medical University, Linhai, Zhejiang 317000, P.R. China
  • Pages: 300-304
    |
    Published online on: November 7, 2014
       https://doi.org/10.3892/ol.2014.2686
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Abstract

Human leukocyte antigen (HLA)‑F, a non‑classical HLA‑class I molecule, has attracted attention as an important immunosuppressive molecule in recent years, although the clinical relevance of HLA‑F expression in cancer patients remains unclear. In the present study, HLA‑F expression in 90 primary hepatocellular carcinoma (HCC) lesions and 55 corresponding adjacent normal liver tissues was analyzed by immunohistochemistry, and the associations between HLA‑F expression and clinicopathological parameters and patient survival times were analyzed. Positive HLA‑F expression was observed in 47.8% (43/90) of the HCC lesions and in 10.9% (6/55) of the normal liver tissues. HLA‑F expression in HCC lesions was significantly correlated with patient gender (P=0.02), and venous or lymphatic invasion (P=0.02). Patients who were HLA‑F‑positive had worse survival times than those who were HLA‑F‑negative (P=0.04). The mean overall survival times for HLA‑F‑negative and ‑positive patients were 44.2 months [95% confidence interval (CI), 37.7‑50.7] and 33.0 months (95% CI, 25.1‑40.8), respectively. Multivariate analysis revealed that HLA‑F was an independent prognostic factor for HCC patients with a hazard ratio of 2.1 (95% CI, 1.0‑4.4). In conclusion, the present study demonstrated that HLA‑F expression was associated with poor survival in HCC patients, and is correlated with tumor cell invasion and metastasis.
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Copy and paste a formatted citation
Spandidos Publications style
Xu Y, Han H, Zhang F, Lv S, Li Z and Fang Z: Lesion human leukocyte antigen‑F expression is associated with a poor prognosis in patients with hepatocellular carcinoma. Oncol Lett 9: 300-304, 2015.
APA
Xu, Y., Han, H., Zhang, F., Lv, S., Li, Z., & Fang, Z. (2015). Lesion human leukocyte antigen‑F expression is associated with a poor prognosis in patients with hepatocellular carcinoma. Oncology Letters, 9, 300-304. https://doi.org/10.3892/ol.2014.2686
MLA
Xu, Y., Han, H., Zhang, F., Lv, S., Li, Z., Fang, Z."Lesion human leukocyte antigen‑F expression is associated with a poor prognosis in patients with hepatocellular carcinoma". Oncology Letters 9.1 (2015): 300-304.
Chicago
Xu, Y., Han, H., Zhang, F., Lv, S., Li, Z., Fang, Z."Lesion human leukocyte antigen‑F expression is associated with a poor prognosis in patients with hepatocellular carcinoma". Oncology Letters 9, no. 1 (2015): 300-304. https://doi.org/10.3892/ol.2014.2686
Copy and paste a formatted citation
x
Spandidos Publications style
Xu Y, Han H, Zhang F, Lv S, Li Z and Fang Z: Lesion human leukocyte antigen‑F expression is associated with a poor prognosis in patients with hepatocellular carcinoma. Oncol Lett 9: 300-304, 2015.
APA
Xu, Y., Han, H., Zhang, F., Lv, S., Li, Z., & Fang, Z. (2015). Lesion human leukocyte antigen‑F expression is associated with a poor prognosis in patients with hepatocellular carcinoma. Oncology Letters, 9, 300-304. https://doi.org/10.3892/ol.2014.2686
MLA
Xu, Y., Han, H., Zhang, F., Lv, S., Li, Z., Fang, Z."Lesion human leukocyte antigen‑F expression is associated with a poor prognosis in patients with hepatocellular carcinoma". Oncology Letters 9.1 (2015): 300-304.
Chicago
Xu, Y., Han, H., Zhang, F., Lv, S., Li, Z., Fang, Z."Lesion human leukocyte antigen‑F expression is associated with a poor prognosis in patients with hepatocellular carcinoma". Oncology Letters 9, no. 1 (2015): 300-304. https://doi.org/10.3892/ol.2014.2686
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