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Article

Expression of P‑gp in acute myeloid leukemia and the reversal function of As2O3 on drug resistance

  • Authors:
    • Feng Gao
    • Wanwei Dong
    • Wei Yang
    • Jia Liu
    • Zhihong Zheng
    • Kailai Sun
  • View Affiliations / Copyright

    Affiliations: Department of Genetics, China Medical University, Shenyang, Liaoning 110001, P.R. China, Laboratory Animal Center, China Medical University, Shenyang, Liaoning 110001, P.R. China
  • Pages: 177-182
    |
    Published online on: November 10, 2014
       https://doi.org/10.3892/ol.2014.2692
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Abstract

To study the expression of P‑glycoprotein (P‑gp) and the reversal function of As2O3, the active ingredient of arsenic, on drug resistance in acute myeloid leukemia (AML) patients, P‑gp and cluster of differentiation 34 (CD34) were examined in primary mononuclear and resistant cells, with or without As2O3. In addition, multidrug resistance gene 1 (MDR1) mRNA expression was investigated in K562/D cells and AML patients. In total, 28.6% of newly‑treated (NT) patients and 59.1% of relapsed/refractory (RR) patients were P‑gpfunction+, and 31.7% of NT patients and 59.1% of RR patients were CD34+. The positivity rate of P‑gpfunction and CD34+ expression in the RR group were significantly higher compared with that in the NT group (P<0.05). In addition, higher CD34+, P‑gpexpression+ and P‑gpfunction+ values were observed in older patients compared with younger patients. MDR1 expression was downregulated in certain patients following treatment with AS2O3. In the present study, the overexpression of P‑gp was the primary cause of drug resistance in the AML patients, and MDR1 expression was downregulated by As2O3 in primary leukemia and drug‑resistant cells.
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Copy and paste a formatted citation
Spandidos Publications style
Gao F, Dong W, Yang W, Liu J, Zheng Z and Sun K: Expression of P‑gp in acute myeloid leukemia and the reversal function of As2O3 on drug resistance. Oncol Lett 9: 177-182, 2015.
APA
Gao, F., Dong, W., Yang, W., Liu, J., Zheng, Z., & Sun, K. (2015). Expression of P‑gp in acute myeloid leukemia and the reversal function of As2O3 on drug resistance. Oncology Letters, 9, 177-182. https://doi.org/10.3892/ol.2014.2692
MLA
Gao, F., Dong, W., Yang, W., Liu, J., Zheng, Z., Sun, K."Expression of P‑gp in acute myeloid leukemia and the reversal function of As2O3 on drug resistance". Oncology Letters 9.1 (2015): 177-182.
Chicago
Gao, F., Dong, W., Yang, W., Liu, J., Zheng, Z., Sun, K."Expression of P‑gp in acute myeloid leukemia and the reversal function of As2O3 on drug resistance". Oncology Letters 9, no. 1 (2015): 177-182. https://doi.org/10.3892/ol.2014.2692
Copy and paste a formatted citation
x
Spandidos Publications style
Gao F, Dong W, Yang W, Liu J, Zheng Z and Sun K: Expression of P‑gp in acute myeloid leukemia and the reversal function of As2O3 on drug resistance. Oncol Lett 9: 177-182, 2015.
APA
Gao, F., Dong, W., Yang, W., Liu, J., Zheng, Z., & Sun, K. (2015). Expression of P‑gp in acute myeloid leukemia and the reversal function of As2O3 on drug resistance. Oncology Letters, 9, 177-182. https://doi.org/10.3892/ol.2014.2692
MLA
Gao, F., Dong, W., Yang, W., Liu, J., Zheng, Z., Sun, K."Expression of P‑gp in acute myeloid leukemia and the reversal function of As2O3 on drug resistance". Oncology Letters 9.1 (2015): 177-182.
Chicago
Gao, F., Dong, W., Yang, W., Liu, J., Zheng, Z., Sun, K."Expression of P‑gp in acute myeloid leukemia and the reversal function of As2O3 on drug resistance". Oncology Letters 9, no. 1 (2015): 177-182. https://doi.org/10.3892/ol.2014.2692
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