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Article

Sulfur inhibits the growth of androgen-independent prostate cancer in vivo

  • Authors:
    • Fei Duan
    • Yuhua Li
    • Liangkang Chen
    • Xiaoyu Zhou
    • Jianxing Chen
    • Hailin Chen
    • Runsheng Li
  • View Affiliations / Copyright

    Affiliations: Shanghai Medical College, Fudan University, Shanghai 200032, P.R. China, Key Laboratory of Contraceptive Drugs and Devices of NPFPC, Shanghai Institute of Planned Parenthood Research, Shanghai 200032, P.R. China
  • Pages: 437-441
    |
    Published online on: November 11, 2014
       https://doi.org/10.3892/ol.2014.2700
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Abstract

Sulfur is a bright yellow crystalline solid at room temperature. The aim of the present study was to investigate the inhibitory effect of sulfur on prostate cancer (PCa) in vivo. Prostate tumors were developed by injecting 22Rv1 or DU‑145 PCa cells into sulfur‑treated or untreated nude mice. The weight and volume of the tumors were measured. The cancer cells were separated from the tumors, and analyzed for their growth rate and clonogenicity in culture. The expression of PCa‑targeted genes was also assessed using real‑time polymerase chain reaction. The rate of growth of 22Rv1 tumors in sulfur‑treated nude mice gradually decreased, and was reduced by 41.99% (P<0.01) after 22 days when compared with that of the control group. In addition, the growth of DU‑145 tumors was also suppressed by 75.16% (P<0.05) after 11 weeks. The clonogenicity of the sulfur‑treated tumor cells decreased by 36.7% when compared with that of the control cells. However, no significant difference in cell growth was identified. mRNA levels of the androgen‑receptor, prostate specific antigen and human Hox (NKX3.1) genes were significantly decreased by 32.8, 48.2 and 42.2% in sulfur‑treated tumors, respectively. Additionally, it was found that the hydrogen sulfide concentration in the serum of sulfur‑treated mice was increased by 4.73% (P<0.05). Sulfur significantly suppressed the growth of PCa in vivo. Since sulfur is a known ingredient used in traditional Chinese medicine, it may be used clinically for the treatment of PCa, independently or in combination with other medicine.
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1 

Pruksachatkunakorn C, Damrongsak M and Sinthupuan S: Sulfur for scabies outbreaks in orphanages. Pediatr Dermatol. 19:448–453. 2002. View Article : Google Scholar : PubMed/NCBI

2 

Kenawi MZ, Morsy TA, Abdalla KF and el Hady HM: Treatment of human scabies by sulfur and permethrin. J Egypt Soc Parasitol. 23:691–696. 1993.PubMed/NCBI

3 

Gupta AK and Nicol K: The use of sulfur in dermatology. J Drugs Dermatol. 3:427–431. 2004.PubMed/NCBI

4 

United States Pharmacopeia. USP35-NF30. The Unites States Pharmacopeial Convention. 4727:2012.

5 

Parcell S: Sulfur in human nutrition and applications in medicine. Altern Med Rev. 7:22–44. 2002.PubMed/NCBI

6 

Lee ZW, Zhou J, Chen CS, et al: The slow-releasing hydrogen sulfide donor, GYY4137, exhibits novel anti-cancer effects in vitro and in vivo. PLoS One. 6:e210772011. View Article : Google Scholar : PubMed/NCBI

7 

Ma K, Liu Y, Zhu Q, et al: H2S donor, S-propargyl-cysteine, increases CSE in SGC-7901 and cancer-induced mice: evidence for a novel anti-cancer effect of endogenous H2S? PLoS One. 6:e205252011. View Article : Google Scholar : PubMed/NCBI

8 

Das A, Banik NL and Ray SK: Garlic compounds generate reactive oxygen species leading to activation of stress kinases and cysteine proteases for apoptosis in human glioblastoma T98G and U87MG cells. Cancer. 110:1083–1095. 2007. View Article : Google Scholar : PubMed/NCBI

9 

Zhang ZM, Zhong N, Gao HQ, et al: Inducing apoptosis and upregulation of Bax and Fas ligand expression by allicin in hepatocellular carcinoma in Balb/c nude mice. Chin Med J (Eng). 119:422–425. 2006.

10 

Zeng JX, Sun JJ, Mo JC, Ma Y and He XS: Inhibition of Allicin on Growth of Neuroblastoma in Vitro and in Vivo [J]. Journal of Sun Yat-Sen University (Medical Sciences). 3:0092009.

11 

Karmakar S, Banik NL, Patel SJ and Ray SK: Garlic compounds induced calpain and intrinsic caspase cascade for apoptosis in human malignant neuroblastoma SH-SY5Y cells. Apoptosis. 12:671–684. 2007. View Article : Google Scholar : PubMed/NCBI

12 

Huggins C and Hodges CV: Studies on prostatic cancer: I. The effect of castration, of estrogen and of androgen injection on serum phosphatases in metastatic carcinoma of the prostate. 1941. J Urol. 168:9–12. 2002. View Article : Google Scholar : PubMed/NCBI

13 

Kozlowski JM, Ellis WJ and Grayhack JT: Advanced prostatic carcinoma. Early versus late endocrine therapy. Urol Clin North Am. 18:15–24. 1991.PubMed/NCBI

14 

Denmeade SR and Isaacs JT: A history of prostate cancer treatment. Nat Rev Cancer. 2:389–396. 2002. View Article : Google Scholar : PubMed/NCBI

15 

Petrylak DP: Current state of castration-resistant prostate cancer. Am J Manag Care. 19:358–365. 2013.

16 

Chi KN, Bjartell A, Dearnaley D, et al: Castration-resistant prostate cancer: from new pathophysiology to new treatment targets. Eur Urol. 56:594–605. 2009. View Article : Google Scholar : PubMed/NCBI

17 

Debes JD and Tindall DJ: Mechanisms of androgen-refractory prostate cancer. N Eng J Med. 351:1488–1490. 2004. View Article : Google Scholar

18 

Hartel A, Didier A, Pfaffl MW and Meyer HH: Characterisation of gene expression patterns in 22RV1 cells for determination of environmental androgenic/antiandrogenic compounds. J Steroid Biochem Mol Biol. 84:231–238. 2003. View Article : Google Scholar : PubMed/NCBI

19 

Kim J and Coetzee GA: Prostate specific antigen gene regulation by androgen receptor. J Cell Biochem. 93:233–241. 2004. View Article : Google Scholar : PubMed/NCBI

20 

Sramkoski RM, Pretlow TG II, Giaconia JM, et al: A new human prostate carcinoma cell line, 22Rv1. In Vitro Cell Dev Biol Anim. 35:403–409. 1999. View Article : Google Scholar : PubMed/NCBI

21 

Ware JL, Paulson DF and Webb KS: 1, 10-Phenanthroline reversibility inhibits proliferation of two human prostate carcinoma cell lines (PC-3 and DU145). Biochem Biophys Res Commun. 124:538–543. 1984. View Article : Google Scholar : PubMed/NCBI

22 

Meletiadis J, Meis JF, Mouton JW, Donnelly JP and Verweij PE: Comparison of NCCLS and 3-(4,5-dimethyl-2-thiazyl)-2, 5-diphenyl-2H-tetrazolium bromide (MTT) methods of in vitro susceptibility testing of filamentous fungi and development of a new simplified method. J Clin Microbiol. 38:2949–2954. 2000.PubMed/NCBI

23 

Sardana G, Jung K, Stephan C and Diamandis EP: Proteomic analysis of conditioned media from the PC3, LNCaP, and 22Rv1 prostate cancer cell lines: discovery and validation of candidate prostate cancer biomarkers. J Proteome Res. 7:3329–3338. 2008. View Article : Google Scholar : PubMed/NCBI

24 

Sciavolino PJ, Abrams EW, Yang L, Austenberg LP, Shen MM and Abate-Shen C: Tissue-specific expression of murine Nkx3.1 in the male urogenital system. Dev Dyn. 209:127–138. 1997. View Article : Google Scholar : PubMed/NCBI

25 

Ha AW, Hong KH, Kim HS and Kim WK: Inorganic sulfur reduces cell proliferation by inhibiting of ErbB2 and ErbB3 protein and mRNA expression in MDA-MB-231 human breast cancer cells. Nutr Res Pract. 7:89–95. 2013. View Article : Google Scholar : PubMed/NCBI

26 

Qin X, Zhang H, Yao X, et al: Variations in circulating sex steroid levels in metastatic prostate cancer patients with combined androgen blockade: observation and implication. Andrology. 1:512–516. 2013. View Article : Google Scholar : PubMed/NCBI

27 

Nishimura S, Hato M, Hyugaji S, et al: Glycomics for drug discovery: metabolic perturbation in androgen-independent prostate cancer cells induced by unnatural hexosamine mimics. Angew Chem Int Ed Engl. 51:3386–3390. 2012. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Duan F, Li Y, Chen L, Zhou X, Chen J, Chen H and Li R: Sulfur inhibits the growth of androgen-independent prostate cancer in vivo. Oncol Lett 9: 437-441, 2015.
APA
Duan, F., Li, Y., Chen, L., Zhou, X., Chen, J., Chen, H., & Li, R. (2015). Sulfur inhibits the growth of androgen-independent prostate cancer in vivo. Oncology Letters, 9, 437-441. https://doi.org/10.3892/ol.2014.2700
MLA
Duan, F., Li, Y., Chen, L., Zhou, X., Chen, J., Chen, H., Li, R."Sulfur inhibits the growth of androgen-independent prostate cancer in vivo". Oncology Letters 9.1 (2015): 437-441.
Chicago
Duan, F., Li, Y., Chen, L., Zhou, X., Chen, J., Chen, H., Li, R."Sulfur inhibits the growth of androgen-independent prostate cancer in vivo". Oncology Letters 9, no. 1 (2015): 437-441. https://doi.org/10.3892/ol.2014.2700
Copy and paste a formatted citation
x
Spandidos Publications style
Duan F, Li Y, Chen L, Zhou X, Chen J, Chen H and Li R: Sulfur inhibits the growth of androgen-independent prostate cancer in vivo. Oncol Lett 9: 437-441, 2015.
APA
Duan, F., Li, Y., Chen, L., Zhou, X., Chen, J., Chen, H., & Li, R. (2015). Sulfur inhibits the growth of androgen-independent prostate cancer in vivo. Oncology Letters, 9, 437-441. https://doi.org/10.3892/ol.2014.2700
MLA
Duan, F., Li, Y., Chen, L., Zhou, X., Chen, J., Chen, H., Li, R."Sulfur inhibits the growth of androgen-independent prostate cancer in vivo". Oncology Letters 9.1 (2015): 437-441.
Chicago
Duan, F., Li, Y., Chen, L., Zhou, X., Chen, J., Chen, H., Li, R."Sulfur inhibits the growth of androgen-independent prostate cancer in vivo". Oncology Letters 9, no. 1 (2015): 437-441. https://doi.org/10.3892/ol.2014.2700
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