A novel mutation of thyroid hormone receptor β in exon 10 in a case of thyroid hormone-resistant non-Hodgkin's lymphoma 
of the thyroid

Chen,Ke; Xie,Yanhong; Zhao,Liling; Zhao,Shaoli; He,Honghui; Mo,Zhaohui

doi:10.3892/ol.2014.2715

February-2015 Volume 9 Issue 2

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February-2015 Volume 9 Issue 2

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Article Open Access

A novel mutation of thyroid hormone receptor β in exon 10 in a case of thyroid hormone-resistant non-Hodgkin's lymphoma of the thyroid

Authors:
- Ke Chen
- Yanhong Xie
- Liling Zhao
- Shaoli Zhao
- Honghui He
- Zhaohui Mo
View Affiliations / Copyright

Affiliations: Department of Endocrinology, Third Xiangya Hospital of Central South University, Changsha, Hunan 410013, P.R. China

Copyright: © Chen et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
Pages: 614-618
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Published online on: November 20, 2014

https://doi.org/10.3892/ol.2014.2715
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Abstract

Only a few previous studies have demonstrated an association between resistance to thyroid hormone (RTH) and thyroid cancer. The current study presents the case of a 67‑year‑old female who was referred to the Third Xiangya Hospital of Central South University with an enlargement of the neck that had grown gradually over two years and subsequently, rapidly enlarged over the two months prior to admission, alongside a slight sensation of shortness of breath. Laboratory data revealed a significantly increased level of thyroid‑stimulating hormone (TSH), total triiodothyronine, total thyroxine, free triiodothyronine, free thyroxine, thyroprotein and thyroglobulin antibody; however, the levels of thyroperoxidase and TSH receptor antibody were within the normal ranges. A thyroid hormone suppression test revealed a TSH reduction of 32%, Magnetic resonance imaging of the pituitary gland was negative for abnormalities. The patient's thyroid pathology revealed a non‑Hodgkin's lymphoma of the thyroid. CHOP + nimustine chemotherapy significantly reduced the clinical symptoms. The genetic analysis revealed a novel point mutation of the thyroid hormone receptor β (THRB) gene in exon 10 (g1680 G to A) in the 3'‑untranslated region of the patient. To the best of our knowledge, this is the first case report of RTH with thyroid non‑Hodgkin's lymphoma, which involved a mutation (g1680 G to A) in exon 10 of THRB.

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