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Print ISSN: 1792-1074 Online ISSN: 1792-1082
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February-2015 Volume 9 Issue 2

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International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

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Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

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Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

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Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

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Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

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Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

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Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

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International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

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International Journal of Epigenetics

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Article

MiR-30a upregulates BCL2A1, IER3 and cyclin D2 expression by targeting FOXL2

  • Authors:
    • Tairen Wang
    • Fei Li
    • Shengjian Tang
  • View Affiliations / Copyright

    Affiliations: Institute of Plastic Surgery, Weifang Medical College, Weifang, Shandong 261041, P.R. China
  • Pages: 967-971
    |
    Published online on: November 20, 2014
       https://doi.org/10.3892/ol.2014.2723
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Abstract

FOXL2 is a transcription factor that is essential for ovarian development. Somatic mutations of FOXL2 are associated with ovarian granulosa cell tumorigenesis. In the present study, the expression of FOXL2 was suppressed by microRNAs using the Ago2 knockdown method in COV434 cells. Online bioinformatics tools were utilized to predict that FOXL2 expression may be repressed by miR‑30 family members, and dual luciferase assay and western blotting were performed to demonstrate that FOXL2 is a target gene of miR‑30a, which is relatively abundant in COV434 cells. Furthermore, miR‑30a overexpression upregulates BCL2A1, IER3 and cyclin D2 expression by inhibiting FOXL2. miR‑30a is known to function as a tumor suppressor in breast cancer, small cell lung cancer and colorectal carcinoma; however, the present study revealed an opposing function of miR‑30a as an oncogene.
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Copy and paste a formatted citation
Spandidos Publications style
Wang T, Li F and Tang S: MiR-30a upregulates BCL2A1, IER3 and cyclin D2 expression by targeting FOXL2. Oncol Lett 9: 967-971, 2015.
APA
Wang, T., Li, F., & Tang, S. (2015). MiR-30a upregulates BCL2A1, IER3 and cyclin D2 expression by targeting FOXL2. Oncology Letters, 9, 967-971. https://doi.org/10.3892/ol.2014.2723
MLA
Wang, T., Li, F., Tang, S."MiR-30a upregulates BCL2A1, IER3 and cyclin D2 expression by targeting FOXL2". Oncology Letters 9.2 (2015): 967-971.
Chicago
Wang, T., Li, F., Tang, S."MiR-30a upregulates BCL2A1, IER3 and cyclin D2 expression by targeting FOXL2". Oncology Letters 9, no. 2 (2015): 967-971. https://doi.org/10.3892/ol.2014.2723
Copy and paste a formatted citation
x
Spandidos Publications style
Wang T, Li F and Tang S: MiR-30a upregulates BCL2A1, IER3 and cyclin D2 expression by targeting FOXL2. Oncol Lett 9: 967-971, 2015.
APA
Wang, T., Li, F., & Tang, S. (2015). MiR-30a upregulates BCL2A1, IER3 and cyclin D2 expression by targeting FOXL2. Oncology Letters, 9, 967-971. https://doi.org/10.3892/ol.2014.2723
MLA
Wang, T., Li, F., Tang, S."MiR-30a upregulates BCL2A1, IER3 and cyclin D2 expression by targeting FOXL2". Oncology Letters 9.2 (2015): 967-971.
Chicago
Wang, T., Li, F., Tang, S."MiR-30a upregulates BCL2A1, IER3 and cyclin D2 expression by targeting FOXL2". Oncology Letters 9, no. 2 (2015): 967-971. https://doi.org/10.3892/ol.2014.2723
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