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Review Open Access

Role of antiviral therapy in reducing recurrence and improving survival in hepatitis B virus-associated hepatocellular carcinoma following curative resection (Review)

  • Authors:
    • Chaohui Zuo
    • Man Xia
    • Qunfeng Wu
    • Haizhen Zhu
    • Jingshi Liu
    • Chen Liu
  • View Affiliations / Copyright

    Affiliations: Department of Gastroduodenal and Pancreatic Surgery, Translation Medicine Research Center of Liver Cancer, Hunan Province Tumor Hospital and Affiliated Tumor Hospital of Xiangya Medical School, Central South University, Changsha, Hunan 410013, P.R. China, Department of Pathology, Immunology and Laboratory Medicine and Shands Cancer Center, University of Florida, Gainesville, FL 32610-0275, USA
    Copyright: © Zuo et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 527-534
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    Published online on: November 21, 2014
       https://doi.org/10.3892/ol.2014.2727
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Abstract

Hepatocellular carcinoma (HCC) is one of the major causes of cancer‑related mortality worldwide, with the majority of cases associated with persistent hepatitis B virus (HBV) or hepatitis C virus infection. In particular, chronic HBV infection is a predominant risk factor for the development of HCC in Asian and African populations. Hepatic resection, liver transplantion and radiofrequency ablation are increasingly used for the curative treatment of HCC, however, the survival rate of HCC patients who have undergone curative resection remains unsatisfactory due to the high recurrence rate. HCC is a complex disease that is typically resistant to the most commonly used types of chemotherapy and radiotherapy; therefore, the development of novel treatment strategies is required to improve the survival rate of this disease. A high viral load of HBV DNA is the most important correctable risk factor for HCC recurrence, for example nucleos(t)ide analogs improve the outcome following curative resection of HBV‑associated HCC, and interferon‑α exhibits antitumor activity against various types of cancer via direct inhibitory effects on tumor cells, anti‑angiogenesis, enhanced immunogenicity of tumors, immunomodulatory effects and liver dysfunction. In the present review, antiviral treatment for HBV‑associated HCC is described as a strategy to reduce recurrence and improve survival.
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Copy and paste a formatted citation
Spandidos Publications style
Zuo C, Xia M, Wu Q, Zhu H, Liu J and Liu C: Role of antiviral therapy in reducing recurrence and improving survival in hepatitis B virus-associated hepatocellular carcinoma following curative resection (Review). Oncol Lett 9: 527-534, 2015.
APA
Zuo, C., Xia, M., Wu, Q., Zhu, H., Liu, J., & Liu, C. (2015). Role of antiviral therapy in reducing recurrence and improving survival in hepatitis B virus-associated hepatocellular carcinoma following curative resection (Review). Oncology Letters, 9, 527-534. https://doi.org/10.3892/ol.2014.2727
MLA
Zuo, C., Xia, M., Wu, Q., Zhu, H., Liu, J., Liu, C."Role of antiviral therapy in reducing recurrence and improving survival in hepatitis B virus-associated hepatocellular carcinoma following curative resection (Review)". Oncology Letters 9.2 (2015): 527-534.
Chicago
Zuo, C., Xia, M., Wu, Q., Zhu, H., Liu, J., Liu, C."Role of antiviral therapy in reducing recurrence and improving survival in hepatitis B virus-associated hepatocellular carcinoma following curative resection (Review)". Oncology Letters 9, no. 2 (2015): 527-534. https://doi.org/10.3892/ol.2014.2727
Copy and paste a formatted citation
x
Spandidos Publications style
Zuo C, Xia M, Wu Q, Zhu H, Liu J and Liu C: Role of antiviral therapy in reducing recurrence and improving survival in hepatitis B virus-associated hepatocellular carcinoma following curative resection (Review). Oncol Lett 9: 527-534, 2015.
APA
Zuo, C., Xia, M., Wu, Q., Zhu, H., Liu, J., & Liu, C. (2015). Role of antiviral therapy in reducing recurrence and improving survival in hepatitis B virus-associated hepatocellular carcinoma following curative resection (Review). Oncology Letters, 9, 527-534. https://doi.org/10.3892/ol.2014.2727
MLA
Zuo, C., Xia, M., Wu, Q., Zhu, H., Liu, J., Liu, C."Role of antiviral therapy in reducing recurrence and improving survival in hepatitis B virus-associated hepatocellular carcinoma following curative resection (Review)". Oncology Letters 9.2 (2015): 527-534.
Chicago
Zuo, C., Xia, M., Wu, Q., Zhu, H., Liu, J., Liu, C."Role of antiviral therapy in reducing recurrence and improving survival in hepatitis B virus-associated hepatocellular carcinoma following curative resection (Review)". Oncology Letters 9, no. 2 (2015): 527-534. https://doi.org/10.3892/ol.2014.2727
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