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Article

Long non‑coding RNA PVT1 is associated with tumor progression and predicts recurrence in hepatocellular carcinoma patients

  • Authors:
    • Chaofeng Ding
    • Zhe Yang
    • Zhen Lv
    • Chengli Du
    • Heng Xiao
    • Chuanhui Peng
    • Shaobing Cheng
    • Haiyang Xie
    • Lin Zhou
    • Jian Wu
    • Shusen Zheng
  • View Affiliations / Copyright

    Affiliations: Division of Hepatobiliary and Pancreatic Surgery, Department of Surgery, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang 310003, P.R. China, Key Laboratory of Combined Multi‑Organ Transplantation, Ministry of Public Health, Hangzhou, Zhejiang 310003, P.R. China
  • Pages: 955-963
    |
    Published online on: November 24, 2014
       https://doi.org/10.3892/ol.2014.2730
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Abstract

PVT1, which maps to chromosome 8q24, is a copy number amplification‑associated long non‑coding RNA. Overexpression of PVT1 is a powerful predictor of tumor progression and patient survival in a diverse range of cancer types. However, the association between PVT1 and hepatocellular carcinoma (HCC) remains unclear. The aim of the present study was to examine the expression pattern of PVT1, and its clinical significance in HCC. Between 2003 and 2012, reverse transcription‑quantitative polymerase chain reaction was used to determine the expression levels of PVT1 in two independent cohorts: Cohort one, 58 HCC resection samples; and cohort 2, 214 HCC transplant samples. Additionally, the correlation between PVT1 expression levels and clinical parameters and outcomes was analyzed. The relative expression levels of PVT1 were significantly higher in cancerous tissues compared with the corresponding non‑cancerous tissues (cohort one, P=0.0016; cohort two, P=0.0274). Furthermore, overexpression of PVT1 was associated with a higher serum α‑fetoprotein expression level (P=0.011) and a higher recurrence rate (P=0.004). Kaplan‑Meier analysis indicated that the patients with high PVT1 expression exhibited poor recurrence‑free survival (P=0.021), and multivariate analysis demonstrated that high levels of PVT1 expression are an independent predictor for HCC recurrence (P=0.042; hazard ratio, 1.653). Thus, the high expression levels of PVT1 in HCC may serve as a novel biomarker for predicting tumor recurrence in HCC patients, and as a potential therapeutic target.
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1 

Jemal A, Bray F, Center MM, et al: Global cancer statistics. CA Cancer J Clin. 61:69–90. 2011. View Article : Google Scholar : PubMed/NCBI

2 

El-Serag HB and Rudolph KL: Hepatocellular carcinoma: epidemiology and molecular carcinogenesis. Gastroenterology. 132:2557–2576. 2007. View Article : Google Scholar : PubMed/NCBI

3 

Cha C, Fong Y, Jarnagin WR, Blumgart LH and DeMatteo RP: Predictors and patterns of recurrence after resection of hepatocellular carcinoma. J Am Coll Surg. 197:753–758. 2003. View Article : Google Scholar : PubMed/NCBI

4 

Shah SA, Cleary SP, Wei AC, et al: Recurrence after liver resection for hepatocellular carcinoma: risk factors, treatment, and outcomes. Surgery. 141:330–339. 2007. View Article : Google Scholar : PubMed/NCBI

5 

Zimmerman MA, Ghobrial RM, Tong MJ, et al: Recurrence of hepatocellular carcinoma following liver transplantation: a review of preoperative and postoperative prognostic indicators. Arch Surg. 143:182–188; discussion 188. 2008. View Article : Google Scholar : PubMed/NCBI

6 

Wilusz JE, Sunwoo H and Spector DL: Long noncoding RNAs: functional surprises from the RNA world. Genes Dev. 23:1494–1504. 2009. View Article : Google Scholar : PubMed/NCBI

7 

Mercer TR, Dinger ME and Mattick JS: Long non-coding RNAs: insights into functions. Nat Rev Genet. 10:155–159. 2009. View Article : Google Scholar : PubMed/NCBI

8 

Tsai MC, Spitale RC and Chang HY: Long intergenic noncoding RNAs: new links in cancer progression. Cancer Res. 71:3–7. 2011. View Article : Google Scholar : PubMed/NCBI

9 

Wang KC and Chang HY: Molecular mechanisms of long noncoding RNAs. Mol Cell. 43:904–914. 2011. View Article : Google Scholar : PubMed/NCBI

10 

Yang Z, Zhou L, Wu LM, et al: Overexpression of long non-coding RNA HOTAIR predicts tumor recurrence in hepatocellular carcinoma patients following liver transplantation. Ann Surg Oncol. 18:1243–1250. 2011. View Article : Google Scholar : PubMed/NCBI

11 

Ishibashi M, Kogo R, Shibata K, et al: Clinical significance of the expression of long non-coding RNA HOTAIR in primary hepatocellular carcinoma. Oncol Rep. 29:946–950. 2013.PubMed/NCBI

12 

Lai MC, Yang Z, Zhou L, et al: Long non-coding RNA MALAT-1 overexpression predicts tumor recurrence of hepatocellular carcinoma after liver transplantation. Med Oncol. 29:1810–1816. 2012. View Article : Google Scholar

13 

Braconi C, Kogure T, Valeri N, et al: microRNA-29 can regulate expression of the long non-coding RNA gene MEG3 in hepatocellular cancer. Oncogene. 30:4750–4756. 2011. View Article : Google Scholar : PubMed/NCBI

14 

Zhang L, Yang F, Yuan JH, et al: Epigenetic activation of the MiR-200 family contributes to H19-mediated metastasis suppression in hepatocellular carcinoma. Carcinogenesis. 34:577–586. 2013. View Article : Google Scholar

15 

Takahashi Y, Sawada G, Kurashige J, et al: Amplification of PVT-1 is involved in poor prognosis via apoptosis inhibition in colorectal cancers. Br J Cancer. 110:164–171. 2014. View Article : Google Scholar :

16 

Guan Y, Kuo WL, Stilwell JL, et al: Amplification of PVT1 contributes to the pathophysiology of ovarian and breast cancer. Clin Cancer Res. 13:5745–5755. 2007. View Article : Google Scholar : PubMed/NCBI

17 

Schlaeger C, Longerich T, Schiller C, et al: Etiology-dependent molecular mechanisms in human hepatocarcinogenesis. Hepatology. 47:511–520. 2008. View Article : Google Scholar

18 

Ding J, Huang S, Wu S, et al: Gain of miR-151 on chromosome 8q24.3 facilitates tumour cell migration and spreading through downregulating RhoGDIA. Nat Cell Biol. 12:390–399. 2010. View Article : Google Scholar : PubMed/NCBI

19 

Edmondson HA and Steiner PE: Primary carcinoma of the liver: a study of 100 cases among 48,900 necropsies. Cancer. 7:462–503. 1954. View Article : Google Scholar : PubMed/NCBI

20 

Greene FL, Page DL, Fleming ID, et al: Liver. AJCC Cancer Staging Manual. 6th edition. Springer; Chicago, IL: pp. 4352002

21 

Mazzaferro V, Regalia E, Doci R, et al: Liver transplantation for the treatment of small hepatocellular carcinomas in patients with cirrhosis. N Engl J Med. 334:693–699. 1996. View Article : Google Scholar : PubMed/NCBI

22 

Yao FY, Ferrell L, Bass NM, et al: Liver transplantation for hepatocellular carcinoma: expansion of the tumor size limits does not adversely impact survival. Hepatology. 33:1394–1403. 2001. View Article : Google Scholar : PubMed/NCBI

23 

Zheng SS, Xu X, Wu J, et al: Liver transplantation for hepatocellular carcinoma: Hangzhou experiences. Transplantation. 85:1726–1732. 2008. View Article : Google Scholar : PubMed/NCBI

24 

Gibb EA, Vucic EA, Enfield KS, et al: Human cancer long non-coding RNA transcriptomes. PLoS One. 6:e259152011. View Article : Google Scholar : PubMed/NCBI

25 

Prensner JR, Iyer MK, Balbin OA, et al: Transcriptome sequencing across a prostate cancer cohort identifies PCAT-1, an unannotated lincRNA implicated in disease progression. Nat Biotechnol. 29:742–749. 2011. View Article : Google Scholar : PubMed/NCBI

26 

Gutschner T and Diederichs S: The hallmarks of cancer: a long non-coding RNA point of view. RNA Biol. 9:703–719. 2012. View Article : Google Scholar : PubMed/NCBI

27 

Guttman M and Rinn JL: Modular regulatory principles of large non-coding RNAs. Nature. 482:339–346. 2012. View Article : Google Scholar : PubMed/NCBI

28 

Rinn JL, Kertesz M, Wang JK, et al: Functional demarcation of active and silent chromatin domains in human HOX loci by noncoding RNAs. Cell. 129:1311–1323. 2007. View Article : Google Scholar : PubMed/NCBI

29 

Tripathi V, Ellis JD, Shen Z, et al: The nuclear-retained noncoding RNA MALAT1 regulates alternative splicing by modulating SR splicing factor phosphorylation. Mol Cell. 39:925–938. 2010. View Article : Google Scholar : PubMed/NCBI

30 

Barsotti AM, Beckerman R, Laptenko O, et al: p53-dependent induction of PVT1 and miR-1204. J Biol Chem. 287:2509–2519. 2012. View Article : Google Scholar :

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Copy and paste a formatted citation
Spandidos Publications style
Ding C, Yang Z, Lv Z, Du C, Xiao H, Peng C, Cheng S, Xie H, Zhou L, Wu J, Wu J, et al: Long non‑coding RNA PVT1 is associated with tumor progression and predicts recurrence in hepatocellular carcinoma patients. Oncol Lett 9: 955-963, 2015.
APA
Ding, C., Yang, Z., Lv, Z., Du, C., Xiao, H., Peng, C. ... Zheng, S. (2015). Long non‑coding RNA PVT1 is associated with tumor progression and predicts recurrence in hepatocellular carcinoma patients. Oncology Letters, 9, 955-963. https://doi.org/10.3892/ol.2014.2730
MLA
Ding, C., Yang, Z., Lv, Z., Du, C., Xiao, H., Peng, C., Cheng, S., Xie, H., Zhou, L., Wu, J., Zheng, S."Long non‑coding RNA PVT1 is associated with tumor progression and predicts recurrence in hepatocellular carcinoma patients". Oncology Letters 9.2 (2015): 955-963.
Chicago
Ding, C., Yang, Z., Lv, Z., Du, C., Xiao, H., Peng, C., Cheng, S., Xie, H., Zhou, L., Wu, J., Zheng, S."Long non‑coding RNA PVT1 is associated with tumor progression and predicts recurrence in hepatocellular carcinoma patients". Oncology Letters 9, no. 2 (2015): 955-963. https://doi.org/10.3892/ol.2014.2730
Copy and paste a formatted citation
x
Spandidos Publications style
Ding C, Yang Z, Lv Z, Du C, Xiao H, Peng C, Cheng S, Xie H, Zhou L, Wu J, Wu J, et al: Long non‑coding RNA PVT1 is associated with tumor progression and predicts recurrence in hepatocellular carcinoma patients. Oncol Lett 9: 955-963, 2015.
APA
Ding, C., Yang, Z., Lv, Z., Du, C., Xiao, H., Peng, C. ... Zheng, S. (2015). Long non‑coding RNA PVT1 is associated with tumor progression and predicts recurrence in hepatocellular carcinoma patients. Oncology Letters, 9, 955-963. https://doi.org/10.3892/ol.2014.2730
MLA
Ding, C., Yang, Z., Lv, Z., Du, C., Xiao, H., Peng, C., Cheng, S., Xie, H., Zhou, L., Wu, J., Zheng, S."Long non‑coding RNA PVT1 is associated with tumor progression and predicts recurrence in hepatocellular carcinoma patients". Oncology Letters 9.2 (2015): 955-963.
Chicago
Ding, C., Yang, Z., Lv, Z., Du, C., Xiao, H., Peng, C., Cheng, S., Xie, H., Zhou, L., Wu, J., Zheng, S."Long non‑coding RNA PVT1 is associated with tumor progression and predicts recurrence in hepatocellular carcinoma patients". Oncology Letters 9, no. 2 (2015): 955-963. https://doi.org/10.3892/ol.2014.2730
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