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Article

Expression and prognostic value of CD97 and its ligand CD55 in pancreatic cancer

  • Authors:
    • Zheng He
    • Hui Wu
    • Yanli Jiao
    • Jun Zheng
  • View Affiliations / Copyright

    Affiliations: Department of General Surgery, The First College of Clinical Medical Sciences, Three Gorges University, Yichang, Hubei 443002, P.R. China
  • Pages: 793-797
    |
    Published online on: December 1, 2014
       https://doi.org/10.3892/ol.2014.2751
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Abstract

CD97 is a member of the epidermal growth factor‑seven transmembrane family. It affects tumor aggressiveness by binding its cellular ligand CD55 and exhibits adhesive properties. Previous studies have shown that CD97 and CD55 are involved in the dedifferentiation, migration, invasiveness and metastasis of tumors. However, little is known regarding the roles of CD97 and CD55 in pancreatic cancer. In this study, immunohistochemistry was used to analyze CD97 and CD55 protein expression in samples obtained from 37 pancreatic cancer patients. CD97 and CD55 were absent or only weakly expressed in the normal pancreatic tissues but strongly expressed in pancreatic cancer tissues (P<0.05), particularly in tissues with lymph node involvement, metastasis or vascular invasion (P<0.05). Notably, CD97 and CD55 were expressed consistently in pancreatic cancer tissues (r2=0.5422; P<0.05). In addition, CD97 and CD55 expression levels were found to significantly correlate with tumor aggressiveness (P<0.01). Multivariate analyses revealed that CD97 and CD55 expression levels were closely associated with prognosis (P<0.05). Taken together, these results indicated that CD97 and its ligand CD55 are upregulated in pancreatic cancers and are closely associated with lymph node involvement, metastasis and vascular invasion. Thus, analysis of both CD97 and CD55 expression may present potential prognostic value for pancreatic cancer.
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Copy and paste a formatted citation
Spandidos Publications style
He Z, Wu H, Jiao Y and Zheng J: Expression and prognostic value of CD97 and its ligand CD55 in pancreatic cancer. Oncol Lett 9: 793-797, 2015.
APA
He, Z., Wu, H., Jiao, Y., & Zheng, J. (2015). Expression and prognostic value of CD97 and its ligand CD55 in pancreatic cancer. Oncology Letters, 9, 793-797. https://doi.org/10.3892/ol.2014.2751
MLA
He, Z., Wu, H., Jiao, Y., Zheng, J."Expression and prognostic value of CD97 and its ligand CD55 in pancreatic cancer". Oncology Letters 9.2 (2015): 793-797.
Chicago
He, Z., Wu, H., Jiao, Y., Zheng, J."Expression and prognostic value of CD97 and its ligand CD55 in pancreatic cancer". Oncology Letters 9, no. 2 (2015): 793-797. https://doi.org/10.3892/ol.2014.2751
Copy and paste a formatted citation
x
Spandidos Publications style
He Z, Wu H, Jiao Y and Zheng J: Expression and prognostic value of CD97 and its ligand CD55 in pancreatic cancer. Oncol Lett 9: 793-797, 2015.
APA
He, Z., Wu, H., Jiao, Y., & Zheng, J. (2015). Expression and prognostic value of CD97 and its ligand CD55 in pancreatic cancer. Oncology Letters, 9, 793-797. https://doi.org/10.3892/ol.2014.2751
MLA
He, Z., Wu, H., Jiao, Y., Zheng, J."Expression and prognostic value of CD97 and its ligand CD55 in pancreatic cancer". Oncology Letters 9.2 (2015): 793-797.
Chicago
He, Z., Wu, H., Jiao, Y., Zheng, J."Expression and prognostic value of CD97 and its ligand CD55 in pancreatic cancer". Oncology Letters 9, no. 2 (2015): 793-797. https://doi.org/10.3892/ol.2014.2751
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