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Article

MicroRNA-133a suppresses colorectal cancer cell invasion by targeting Fascin1

Retraction in: /10.3892/ol.2021.12905
  • Authors:
    • Keyan Zheng
    • Weicheng Liu
    • Ye Liu
    • Congqing Jiang
    • Qun Qian
  • View Affiliations / Copyright

    Affiliations: Department of Colorectal and Anal Surgery, Zhongnan Hospital of Wuhan University, Wuhan, Hubei 430071, P.R. China
  • Pages: 869-874
    |
    Published online on: December 1, 2014
       https://doi.org/10.3892/ol.2014.2753
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Abstract

MicroRNAs (miRs) are a type of small non‑coding RNA molecule that are involved in gene silencing and the regulation of cancer progression; miR‑133a in particular has been implicated in colorectal cancer, although its specific role and underlying mechanism have yet to be determined. In the present study, the expression level of miR‑133a was significantly downregulated in a number of colorectal cancer cell lines, as well as in colorectal cancer tissues compared with the normal adjacent tissues. Furthermore, the Fascin1 (FSCN1) gene was identified as a direct target of miR‑133a, and the protein expression level of FSCN1 was negatively regulated by miR‑133a in colorectal cancer cells. Additionally, restoration of miR‑133a expression and downregulation of FSCN1 protein expression suppressed colorectal cancer cell invasion, while overexpression of FSCN1 reversed the inhibitory effect of miR‑133a upregulation on colorectal cancer cell invasion. Thus, the present data indicates that miR‑133a may at least partially suppress colorectal cancer cell invasion, possibly via the inhibition of FSCN1 expression. The present study highlights the important role of miR‑133a in the progression of colorectal cancer.
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Copy and paste a formatted citation
Spandidos Publications style
Zheng K, Liu W, Liu Y, Jiang C and Qian Q: MicroRNA-133a suppresses colorectal cancer cell invasion by targeting Fascin1 Retraction in /10.3892/ol.2021.12905. Oncol Lett 9: 869-874, 2015.
APA
Zheng, K., Liu, W., Liu, Y., Jiang, C., & Qian, Q. (2015). MicroRNA-133a suppresses colorectal cancer cell invasion by targeting Fascin1 Retraction in /10.3892/ol.2021.12905. Oncology Letters, 9, 869-874. https://doi.org/10.3892/ol.2014.2753
MLA
Zheng, K., Liu, W., Liu, Y., Jiang, C., Qian, Q."MicroRNA-133a suppresses colorectal cancer cell invasion by targeting Fascin1 Retraction in /10.3892/ol.2021.12905". Oncology Letters 9.2 (2015): 869-874.
Chicago
Zheng, K., Liu, W., Liu, Y., Jiang, C., Qian, Q."MicroRNA-133a suppresses colorectal cancer cell invasion by targeting Fascin1 Retraction in /10.3892/ol.2021.12905". Oncology Letters 9, no. 2 (2015): 869-874. https://doi.org/10.3892/ol.2014.2753
Copy and paste a formatted citation
x
Spandidos Publications style
Zheng K, Liu W, Liu Y, Jiang C and Qian Q: MicroRNA-133a suppresses colorectal cancer cell invasion by targeting Fascin1 Retraction in /10.3892/ol.2021.12905. Oncol Lett 9: 869-874, 2015.
APA
Zheng, K., Liu, W., Liu, Y., Jiang, C., & Qian, Q. (2015). MicroRNA-133a suppresses colorectal cancer cell invasion by targeting Fascin1 Retraction in /10.3892/ol.2021.12905. Oncology Letters, 9, 869-874. https://doi.org/10.3892/ol.2014.2753
MLA
Zheng, K., Liu, W., Liu, Y., Jiang, C., Qian, Q."MicroRNA-133a suppresses colorectal cancer cell invasion by targeting Fascin1 Retraction in /10.3892/ol.2021.12905". Oncology Letters 9.2 (2015): 869-874.
Chicago
Zheng, K., Liu, W., Liu, Y., Jiang, C., Qian, Q."MicroRNA-133a suppresses colorectal cancer cell invasion by targeting Fascin1 Retraction in /10.3892/ol.2021.12905". Oncology Letters 9, no. 2 (2015): 869-874. https://doi.org/10.3892/ol.2014.2753
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