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Primary pulmonary amyloidosis misdiagnosed as malignancy on dual-time‑point fluoro-deoxyglucose positron emission tomography/computed tomography: A case report and review of the literature

  • Authors:
    • Meng‑Jie Dong
    • Kui Zhao
    • Zhen‑Feng Liu
    • Guo‑Lin Wang
    • Jun Yang
  • View Affiliations / Copyright

    Affiliations: Positron Emission Tomography Center, First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, Zhejiang 310003, P.R. China, Department of Nuclear Medicine, First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, Zhejiang 310003, P.R. China
    Copyright: © Dong et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 591-594
    |
    Published online on: December 8, 2014
       https://doi.org/10.3892/ol.2014.2778
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Abstract

Primary pulmonary amyloidosis is an uncommon manifestation, characterized by amyloid deposition in the lungs and other associated tissue. The clinical presentation of amyloidosis is variable, with non‑specific symptoms. The current study reports the case of a 59‑year‑old female presenting with primary pulmonary amyloidosis, indistinguishable from lung malignancy based on 18F‑fluoro‑deoxyglucose (18F‑FDG) accumulation on dual‑time‑point (DTP) FDG‑positron emission tomography/computed tomography (PET/CT) imaging and the similarities in morphological changes. A percutaneous CT‑guided thoracoscopic biopsy was subsequently performed. Histological examination revealed that the specimens contained amorphous, homogeneous material with a number of polyclonal plasma cells, lymphocytes and giant cells. A diagnosis of primary nodular parenchymal pulmonary amyloidosis was determined, and the patient was discharged without chemotherapy. The patient remained in good clinical condition during follow-up. The present case indicated that localized nodular amyloidosis with increased FDG uptake on DTP FDG PET must be considered in the differential diagnosis of growing lung nodules, and that a histological examination must be conducted to distinguish this condition from malignancies of the lung.
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1 

Utz JP, Swensen SJ and Gertz MA: Pulmonary amyloidosis. The Mayo Clinic experience from 1980 to 1993. Ann Intern Med. 124:407–413. 1996. View Article : Google Scholar : PubMed/NCBI

2 

Eguchi T, Yoshida K, Kobayashi N, et al: Localized nodular amyloidosis of the lung. Gen Thorac Cardiovasc Surg. 59:715–717. 2011. View Article : Google Scholar : PubMed/NCBI

3 

Lesser A: Ein Fall von Enchondroma osteiodes mixtum der Lunge mit partieller amyloid Entotung. Virchows Arch (Pathol Anat). 69:404–408. 1877. View Article : Google Scholar

4 

Ding L, Li W, Wang K, Chen Y, Xu H, Wang H and Shen H: Primary tracheobronchial amyloidosis in China: analysis of 64 cases and a review of literature. J Huazhong Univ Sci Technolog Med Sci. 30:599–603. 2010. View Article : Google Scholar : PubMed/NCBI

5 

Fiorelli A, Accardo M, Galluccio G and Santini M: Tracheobronchial amyloidosis treated by endobronchial laser resection and self expanding Y stent. Arch Bronconeumol. 49:303–305. 2013. View Article : Google Scholar : PubMed/NCBI

6 

O’Regan A, Fenlon HM, Beamis JF Jr, et al: Tracheobronchial amyloidosis. The Boston University experience from 1984 to 1999. Medicine (Baltimore). 79:69–79. 2000. View Article : Google Scholar

7 

Cresner R, Mahmood S, Chen J, et al: Thoracic amyloidomas: Two case reports of an evasive diagnosis. JRSM Open. 5:20542704145272802014. View Article : Google Scholar : PubMed/NCBI

8 

Gillmore JD and Hawkins PN: Amyloidosis and the respiratory tract. Thorax. 54:444–451. 1999. View Article : Google Scholar : PubMed/NCBI

9 

Ishii S, Kubota K, Minamimoto R, et al: Lung amyloid nodule detected by 99mTc-aprotinin scintigraphy. Ann Nucl Med. 26:522–526. 2012. View Article : Google Scholar : PubMed/NCBI

10 

Jeong YJ, Yi CA and Lee KS: Solitary pulmonary nodules: detection, characterization, and guidance for further diagnostic workup and treatment. AJR Am J Roentgenol. 188:57–68. 2007. View Article : Google Scholar

11 

Lan XL, Zhang YX, Wu ZJ, Jia Q, Wei H and Gao ZR: The value of dual time point (18)F-FDG PET imaging for the differentiation between malignant and benign lesions. Clin Radiol. 63:756–764. 2008. View Article : Google Scholar : PubMed/NCBI

12 

Tan H, Guan Y, Zhao J and Lin X: Findings of pulmonary amyloidosis on dual phase FDG PET/CT imaging. Clin Nucl Med. 35:206–207. 2010. View Article : Google Scholar : PubMed/NCBI

13 

Berk JL, O’Regan A and Skinner M: Pulmonary and tracheobronchial amyloidosis. Semin Respir Crit Care Med. 23:155–165. 2002. View Article : Google Scholar

14 

Orlacchio A, Schillaci O, Antonelli L, D’Urso S, et al: Solitary pulmonary nodules: morphological and metabolic characterisation by FDG-PET-MDCT. Radiol Med. 112:157–173. 2007. View Article : Google Scholar : PubMed/NCBI

15 

Gould MK, Maclean CC, Kuschner WG, Rydzak CE and Owens DK: Accuracy of positron emission tomography for diagnosis of pulmonary nodules and mass lesions: a meta-analysis. JAMA. 285:914–924. 2001. View Article : Google Scholar : PubMed/NCBI

16 

Jeong YJ, Lee KS and Kwon OJ: Diagnosis and management of solitary pulmonary nodules. Expert Rev Respir Med. 2:767–777. 2008. View Article : Google Scholar : PubMed/NCBI

17 

Kim SK, Allen-Auerbach M, Goldin J, et al: Accuracy of PET/CT in characterization of solitary pulmonary lesions. J Nucl Med. 48:214–220. 2007.PubMed/NCBI

18 

Demura Y, Tsuchida T, Ishizaki T, et al: 18F-FDG accumulation with PET for differentiation between benign and malignant lesions in the thorax. J Nucl Med. 44:540–548. 2003.PubMed/NCBI

19 

Matthies A, Hickeson M, Cuchiara A and Alavi A: Dual time point 18F-FDG PET for the evaluation of pulmonary nodules. J Nucl Med. 43:871–875. 2002.PubMed/NCBI

20 

Ooi GC, Khong PL and Yau YY: Advances in imaging of the solitary pulmonary nodule. Hong Kong Med J. 10:107–116. 2004.PubMed/NCBI

21 

Zhang LN, Xue XY, Wang N and Wang JX: Mimicking pulmonary multiple metastatic tumors: A case of primary nodular parenchymal pulmonary amyloidosis with review of the literature. Oncol Lett. 4:1366–1370. 2012.PubMed/NCBI

22 

Khan AM, Manzoor K, Jain V, Mahadevia P and Berman A: Detection of nodular pulmonary amyloid by PET positive scan - deception for lung cancer. Rev Port Pneumol. 18:299–303. 2012. View Article : Google Scholar : PubMed/NCBI

23 

Soussan M, Ouvrier MJ, Pop G, et al: Tracheobronchial FDG uptake in primary amyloidosis detected by PET/CT. Clin Nucl Med. 36:723–724. 2011. View Article : Google Scholar : PubMed/NCBI

24 

Alkhawaldeh K, Bural G, Kumar R and Alavi A: Impact of dual-time-point (18)F-FDG PET imaging and partial volume correction in the assessment of solitary pulmonary nodules. Eur J Nucl Med Mol Imaging. 35:246–252. 2008. View Article : Google Scholar

25 

Erasmus JJ, Connolly JE, McAdams HP and Roggli VL: Solitary pulmonary nodules: Part I. Morphologic evaluation for differentiation of benign and malignant lesions. Radiographics. 20:43–58. 2000. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Dong MJ, Zhao K, Liu ZF, Wang GL and Yang J: Primary pulmonary amyloidosis misdiagnosed as malignancy on dual-time‑point fluoro-deoxyglucose positron emission tomography/computed tomography: A case report and review of the literature. Oncol Lett 9: 591-594, 2015.
APA
Dong, M., Zhao, K., Liu, Z., Wang, G., & Yang, J. (2015). Primary pulmonary amyloidosis misdiagnosed as malignancy on dual-time‑point fluoro-deoxyglucose positron emission tomography/computed tomography: A case report and review of the literature. Oncology Letters, 9, 591-594. https://doi.org/10.3892/ol.2014.2778
MLA
Dong, M., Zhao, K., Liu, Z., Wang, G., Yang, J."Primary pulmonary amyloidosis misdiagnosed as malignancy on dual-time‑point fluoro-deoxyglucose positron emission tomography/computed tomography: A case report and review of the literature". Oncology Letters 9.2 (2015): 591-594.
Chicago
Dong, M., Zhao, K., Liu, Z., Wang, G., Yang, J."Primary pulmonary amyloidosis misdiagnosed as malignancy on dual-time‑point fluoro-deoxyglucose positron emission tomography/computed tomography: A case report and review of the literature". Oncology Letters 9, no. 2 (2015): 591-594. https://doi.org/10.3892/ol.2014.2778
Copy and paste a formatted citation
x
Spandidos Publications style
Dong MJ, Zhao K, Liu ZF, Wang GL and Yang J: Primary pulmonary amyloidosis misdiagnosed as malignancy on dual-time‑point fluoro-deoxyglucose positron emission tomography/computed tomography: A case report and review of the literature. Oncol Lett 9: 591-594, 2015.
APA
Dong, M., Zhao, K., Liu, Z., Wang, G., & Yang, J. (2015). Primary pulmonary amyloidosis misdiagnosed as malignancy on dual-time‑point fluoro-deoxyglucose positron emission tomography/computed tomography: A case report and review of the literature. Oncology Letters, 9, 591-594. https://doi.org/10.3892/ol.2014.2778
MLA
Dong, M., Zhao, K., Liu, Z., Wang, G., Yang, J."Primary pulmonary amyloidosis misdiagnosed as malignancy on dual-time‑point fluoro-deoxyglucose positron emission tomography/computed tomography: A case report and review of the literature". Oncology Letters 9.2 (2015): 591-594.
Chicago
Dong, M., Zhao, K., Liu, Z., Wang, G., Yang, J."Primary pulmonary amyloidosis misdiagnosed as malignancy on dual-time‑point fluoro-deoxyglucose positron emission tomography/computed tomography: A case report and review of the literature". Oncology Letters 9, no. 2 (2015): 591-594. https://doi.org/10.3892/ol.2014.2778
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