3-Bromopyruvate inhibits human gastric cancer tumor growth in nude mice via the inhibition of glycolysis

  • Authors:
    • Shu‑Lin Xian
    • Wei Cao
    • Xiao‑Dong Zhang
    • Yun‑Fei Lu
  • View Affiliations

  • Published online on: December 8, 2014     https://doi.org/10.3892/ol.2014.2779
  • Pages: 739-744
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Abstract

Tumor cells primarily depend upon glycolysis in order to gain energy. Therefore, the inhibition of glycolysis may inhibit tumor growth. Our previous study demonstrated that 3‑bromopyruvate (3‑BrPA) inhibited gastric cancer cell proliferation in vitro. However, the ability of 3‑BrPA to suppress tumor growth in vivo, and its underlying mechanism, have yet to be elucidated. The aim of the present study was to investigate the inhibitory effect of 3‑BrPA in an animal model of gastric cancer. It was identified that 3‑BrPA exhibited strong inhibitory effects upon xenograft tumor growth in nude mice. In addition, the antitumor function of 3‑BrPA exhibited a dose‑effect association, which was similar to that of the chemotherapeutic agent, 5‑fluorouracil. Furthermore, 3‑BrPA exhibited low toxicity in the blood, liver and kidneys of the nude mice. The present study hypothesized that the inhibitory effect of 3‑BrPA is achieved through the inhibition of hexokinase activity, which leads to the downregulation of B‑cell lymphoma 2 (Bcl‑2) expression, the upregulation of Bcl‑2‑associated X protein expression and the subsequent activation of caspase‑3. These data suggest that 3‑BrPA may be a novel therapy for the treatment of gastric cancer.
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February-2015
Volume 9 Issue 2

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Spandidos Publications style
Xian SL, Cao W, Zhang XD and Lu YF: 3-Bromopyruvate inhibits human gastric cancer tumor growth in nude mice via the inhibition of glycolysis. Oncol Lett 9: 739-744, 2015
APA
Xian, S., Cao, W., Zhang, X., & Lu, Y. (2015). 3-Bromopyruvate inhibits human gastric cancer tumor growth in nude mice via the inhibition of glycolysis. Oncology Letters, 9, 739-744. https://doi.org/10.3892/ol.2014.2779
MLA
Xian, S., Cao, W., Zhang, X., Lu, Y."3-Bromopyruvate inhibits human gastric cancer tumor growth in nude mice via the inhibition of glycolysis". Oncology Letters 9.2 (2015): 739-744.
Chicago
Xian, S., Cao, W., Zhang, X., Lu, Y."3-Bromopyruvate inhibits human gastric cancer tumor growth in nude mice via the inhibition of glycolysis". Oncology Letters 9, no. 2 (2015): 739-744. https://doi.org/10.3892/ol.2014.2779