Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Oncology Letters
Join Editorial Board Propose a Special Issue
Print ISSN: 1792-1074 Online ISSN: 1792-1082
Journal Cover
February-2015 Volume 9 Issue 2

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
February-2015 Volume 9 Issue 2

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article

Cytokine-induced killer cells: A novel immunotherapy strategy for leukemia

  • Authors:
    • Xin‑Yu Yang
    • Hui Zeng
    • Fang‑Ping Chen
  • View Affiliations / Copyright

    Affiliations: Depatment of Haematology, The Third Xiangya Hospital, Central South University, Changsha, Hunan 410013, P.R. China, Department of Hematology, Xiangya Hospital, Central South University, Changsha, Hunan 410008, P.R. China
  • Pages: 535-541
    |
    Published online on: December 8, 2014
       https://doi.org/10.3892/ol.2014.2780
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Cytokine‑induced killer (CIK) cells are NK‑like T cells derived from peripheral blood mononuclear cells that are co‑stimulated and expanded using cytokines for 14‑21 days in vitro. CIK cells are a heterogeneous subset of highly‑efficient cytotoxic T effector cells that mediate major histocompatibility complex‑unrestricted cytotoxicity against a broad array of tumor cells. These effector cells are generated from patients with leukemia or healthy donors who demonstrate similar cytotoxic activity against leukemia blasts. Allogeneic CIK cells retain the ability to produce the graft versus tumor response and generate minimal graft versus host disease. In addition, CIK cells possess no cytotoxicity against normal hematopoietic stem cells in vivo. Leukemia recurrence remains a formidable obstacle, but adoptive immunotherapy offers promise for the eradication of minimal residual disease and prevention of leukemia relapse following hematopoietic stem cell transplantation. CIK cell infusion started a novel generation of adoptive immunotherapy and exhibits particular potential applications in the area of hematological malignancy. In the present study, the previous strategies of leukemia immunotherapy using CIK cells are reviewed and the future directions of development are discussed.
View Figures
View References

1 

Burnett AK, Kell WJ, Goldstone AH, et al: The addition of gemtuzumab ozogamicin to induction chemotherapy for AML improves disease free survival without extra toxicity: Preliminary analysis of 1115 patients in the MRC AML15 Trial. ASH Annual Meeting Abstracts. 108:132006.

2 

Bassan R, Spinelli O, Oldani E, et al: Improved risk classification for risk-specific therapy based on the molecular study of minimal residual disease (MRD) in adult acute lymphoblastic leukemia (ALL). Blood. 113:4153–4162. 2009. View Article : Google Scholar : PubMed/NCBI

3 

Oran B and de Lima M: Prevention and treatment of acute myeloid leukemia relapse after allogeneic stem cell transplantation. Curr Opin Hematol. 18:388–394. 2011. View Article : Google Scholar : PubMed/NCBI

4 

Brentjens RJ, Rivière I, Park J H, et al: Safety and persistence of adoptively transferred autologous CD19- targeted T cells in patients with relapsed or chemotherapy refractory B-cell leukemias. Blood. 118:4817–4828. 2011. View Article : Google Scholar : PubMed/NCBI

5 

Ruggeri L, Mancusi A, Burchielli E, et al: Natural killer cell alloreactivity and haplo-identical hematopoietic transplantation. Cytotherapy. 8:554–558. 2006. View Article : Google Scholar : PubMed/NCBI

6 

Colvin GA, Berz D, Ramanathan M, et al: Nonengraftment haploidentical cellular immunotherapy for refractory malignancies: tumor responses without chimerism. Biol Blood Marrow Transplant. 15:421–431. 2009. View Article : Google Scholar : PubMed/NCBI

7 

Warlick ED, DeFor T, Blazar BR, et al: Successful remission rates and survival after lymphodepleting chemotherapy and donor lymphocyte infusion for relapsed hematologic malignancies postallogeneic hematopoietic cell transplantation. Biol Blood Marrow Transplant. 18:480–486. 2012. View Article : Google Scholar

8 

Barrett AJ and Le Blanc K: Immunotherapy prospects for acute myeloid leukaemia. Clin Exp Immunol. 161:223–232. 2010.PubMed/NCBI

9 

Schmidt-Wolf IG, Negrin RS, Kiem HP, et al: Use of a SCID mouse/human lymphoma model to evaluate cytokine-induced killer cells with potent antitumor cell activity. J Exp Med. 174:139–149. 1991. View Article : Google Scholar : PubMed/NCBI

10 

Vivier E, Ugolini S, Blaise D, et al: Targeting natural killer cells and natural killer T cells in cancer. Nat Rev Immunol. 12:239–252. 2012. View Article : Google Scholar : PubMed/NCBI

11 

Gütgemann S, Frank S, Strehl J and Schmidt-Wolf IG: Cytokine-induced killer cells are type II natural killer T cells. Ger Med Sci. 5:Doc072007.PubMed/NCBI

12 

Sangiolo D, Martinuzzi E, Todorovic M, et al: Alloreactivity and anti-tumor activity segregate within two distinct subsets of cytokine-induced killer (CIK) cells: implications for their infusion across major HLA barriers. Int Immunol. 20:841–848. 2008. View Article : Google Scholar : PubMed/NCBI

13 

Kim HM, Kang JS, Lim J, et al: Antitumor activity of cytokine-induced killer cells in nude mouse xenograft model. Arch Pharm Res. 32:781–787. 2009. View Article : Google Scholar : PubMed/NCBI

14 

Linn YC, Lau SK, Liu BH, et al: Characterization of the recognition and functional heterogeneity exhibited by cytokine-induced killer cell subsets against acute myeloid leukaemia target cell. Immunology. 126:423–435. 2009. View Article : Google Scholar :

15 

Franceschetti M, Pievani A, Borleri G, et al: Cytokine-induced killer cells are terminally differentiated activated CD8 cytotoxic T-EMRA lymphocytes. Exp Hematol. 37:616–628. 2009. View Article : Google Scholar : PubMed/NCBI

16 

Verneris MR: Role of NKG2D signaling in the cytotoxicity of activated and expanded CD8+ T cells. Blood. 103:3065–3072. 2004. View Article : Google Scholar : PubMed/NCBI

17 

Linn YC, Wang SM and Hui KM: Comparative gene expression profiling of cytokine-induced killer cells in response to acute myloid leukemic and acute lymphoblastic leukemic stimulators using oligonucleotide arrays. Exp Hematol. 33:671–681. 2005. View Article : Google Scholar : PubMed/NCBI

18 

Pievani A, Borleri G, Pende D, et al: Dual-functional capability of CD3+ CD56+ CIK cells, a T-cell subset that acquires NK function and retains TCR-mediated specific cytotoxicity. Blood. 118:3301–3310. 2011. View Article : Google Scholar : PubMed/NCBI

19 

Yu J, Zhang W, Jiang H, et al: CD4+ T cells in CIKs (CD4+ CIKs) reversed resistance to Fas-mediated apoptosis through CD40/CD40L ligation rather than IFN-gamma stimulation. Cancer Biother Radiopharm. 23:342–354. 2008. View Article : Google Scholar : PubMed/NCBI

20 

Hoyle C, Bangs CD, Chang P, et al: Expansion of Philadelphia chromosome-negative CD3(+)CD56(+) cytotoxic cells from chronic myeloid leukemia patients: in vitro and in vivo efficacy in severe combined immunodeficiency disease mice. Blood. 92:3318–3327. 1998.PubMed/NCBI

21 

Linn YC, Lau LC and Hui KM: Generation of cytokine-induced killer cells from leukemic samples with in vitro cytotoxicity against autologous and allogeneic leukaemic blasts. Br J Haematol. 116:78–86. 2002. View Article : Google Scholar : PubMed/NCBI

22 

Kornacker M, Moldenhauer G, Herbst M, et al: Cytokine-induced killer cells against autologous CLL: direct cytotoxic effects and induction of immune accessory molecules by interferon-gamma. Int J Cancer. 119:1377–1382. 2006. View Article : Google Scholar : PubMed/NCBI

23 

Scheffold C, Brandt K, Johnston V, et al: Potential of autologous immunologic effector cells for bone marrow purging in patients with chronic myeloid leukemia. Bone Marrow Transplant. 15:33–39. 1995.PubMed/NCBI

24 

Nishimura R, Baker J, Beilhack A, et al: In vivo trafficking and survival of cytokine-induced killer cells resulting in minimal GVHD with retention of antitumor activity. Blood. 112:2563–2574. 2008. View Article : Google Scholar : PubMed/NCBI

25 

Sangiolo D, Mesiano G, Carnevale-Schianca F, et al: Cytokine induced killer cells as adoptive immunotherapy strategy to augment graft versus tumor after hematopoietic cell transplantation. Expert Opin Biol Ther. 9:831–840. 2009. View Article : Google Scholar : PubMed/NCBI

26 

Mase S, Fujiki T, Kuroda R, Araki R, et al: Allogeneic cytokine-induced killer cells eliminate host dendritic cells due to the enhanced killing activity by IFN-gamma, leading to less graft-versus-host disease. Blood. 122:44952013.

27 

Yun YS, Hargrove ME and Ting CC: In vivo antitumor activity of anti-CD3-induced activated killer cells. Cancer Res. 49:4770–4774. 1989.PubMed/NCBI

28 

Rosenberg SA, Spiess P and Lafreniere R: A new approach to the adoptive immunotherapy of cancer with tumor-infiltrating lymphocytes. Science. 233:1318–1321. 1986. View Article : Google Scholar : PubMed/NCBI

29 

Grabert RC, Cousens LP, Smith JA, Olson S, Gall J, Young WB, et al: Human T cells armed with Her2/neu bispecific antibodies divide, are cytotoxic, and secrete cytokines with repeated stimulation. Clin Cancer Res. 12:569–576. 2006. View Article : Google Scholar : PubMed/NCBI

30 

Schmidt-Wolf GD, Negrin RS and Schmidt-Wolf IG: Activated T cells and cytokine-induced CD3+CD56+ killer cells. Ann Hematol. 74:51–56. 1997. View Article : Google Scholar : PubMed/NCBI

31 

Raulet DH, Gasser S, Gowen BG, et al: Regulation of ligands for the NKG2D activating receptor. Annu Rev Immunol. 31:413–441. 2013. View Article : Google Scholar : PubMed/NCBI

32 

Vesely MD and Schreiber RD: Cancer immunoediting: antigens, mechanisms, and implications to cancer immunotherapy. Ann NY Acad Sci. 1284:1–5. 2013. View Article : Google Scholar : PubMed/NCBI

33 

Huang B, Sikorski R, Sampath P and Thorne SH: Modulation of NKG2D-ligand cell surface expression enhances immune cell therapy of cancer. J Immunother. 34:289–296. 2011. View Article : Google Scholar : PubMed/NCBI

34 

Wang QJ, Wang H, Pan K, et al: Comparative study on anti-tumor immune response of autologous cytokine-induced killer (CIK) cells, dendritic cells-CIK (DC-CIK), and semi-allogeneic DC-CIK. Chin J Cancer. 29:641–648. 2010. View Article : Google Scholar : PubMed/NCBI

35 

Ge W, Li CH, Zhang W, et al: Coculture of dendritic cell with cytokine-induced killer results in a significant increase in cytotoxic activity of CIK to tumor cells in vitro and in vivo. Zhonghua Xue Ye Xue Za Zhi. 25:277–280. 2004.(In Chinese). PubMed/NCBI

36 

Rettinger E, Kuçi S, Naumann I, et al: The cytotoxic potential of interleukin-15-stimulated cytokine-induced killer cells against leukemia cells. Cytotherapy. 14:91–103. 2012. View Article : Google Scholar

37 

Zhao N, Zhao MF, Rajbhandary S, et al: Effects of humanized interleukin 21 on anti-leukemic activity of cytokine induced killer cells and the mechanism. Zhonghua Xue Ye Xue Za Zhi. 33:823–828. 2012.(In Chinese).

38 

Durrieu L, Gregoire-Gauthier J, Dieng MM, et al: Human interferon-alpha increases the cytotoxic effect of CD56(+) cord blood-derived cytokine-induced killer cells on human B-acute lymphoblastic leukemia cell lines. Cytotherapy. 14:1245–1257. 2012. View Article : Google Scholar : PubMed/NCBI

39 

Xia W, Yu X, Wang P, et al: The cytotoxicity of IL-24 gene-modified CIK cells to HL-60 cells. Chin J Immunol. 25:1080–1084. 2009.

40 

Marin V, Kakuda H, Dander E, et al: Enhancement of the anti-leukemic activity of cytokine induced killer cells with an anti-CD19 chimeric receptor delivering a 4-1BB-zeta activating signal. Exp Hematol. 35:1388–1397. 2007. View Article : Google Scholar : PubMed/NCBI

41 

Marin V, Pizzitola I, Agostoni V, et al: Cytokine-induced killer cells for cell therapy of acute myeloid leukemia: improvement of their immune activity by expression of CD33-specific chimeric receptors. Haematologica. 95:2144–2152. 2010. View Article : Google Scholar : PubMed/NCBI

42 

Tettamanti S, Marin V, Pizzitola I, et al: Targeting of acute myeloid leukaemia by cytokine. Induced killer cells redirected with a novel CD123-specific chimeric antigen receptor. Bri J Haematol. 161:389–401. 2013. View Article : Google Scholar

43 

Hu L, Cao D, Li Y, et al: Resveratrol sensitized leukemia stem cell-like KG-1a cells to cytokine-induced killer cells-mediated cytolysis through NKG2D ligands and TRAIL receptors. Cancer Biol Ther. 13:516–526. 2012. View Article : Google Scholar : PubMed/NCBI

44 

Zhang JH, Liu LQ, He YL, et al: Cytotoxic effect of trans-cinnamaldehyde on human leukemia K562 cells. Acta Pharmacol Sin. 31:861–866. 2010. View Article : Google Scholar : PubMed/NCBI

45 

Kaneko T, Fusauch Y, Kakui Y, et al: Cytotoxicity of cytokine-induced killer cells coated with bispecific antibody against acute myeloid leukemia cells. Leuk Lymphoma. 14:219–229. 1994. View Article : Google Scholar : PubMed/NCBI

46 

Bonanno G, Iudicone P, Mariotti A, et al: Thymoglobulin, interferon-γ and interleukin-2 efficiently expand cytokine-induced killer (CIK) cells in clinical-grade cultures. J Transl Med. 8:1292010. View Article : Google Scholar

47 

Zheng Z, Yuna Z, Huimin Z, Liu Q, et al: Clinical study of DC-CIK (dendritic cells and cytokine-induced killer cells) eliminate minimal residual leukemia. Blood. 122:14502013.

48 

Thanendrarajan S, Nowak M, Abken H and Schmidt-Wolf IG: Combining cytokine-induced killer cells with vaccination in cancer immunotherapy: More than one plus one? Leuk Res. 35:1136–1142. 2011. View Article : Google Scholar : PubMed/NCBI

49 

Yang Z, Zhang Q, Xu K, et al: Combined therapy with cytokine-induced killer cells and oncolytic adenovirus expressing IL-12 induce enhanced antitumor activity in liver tumor model. PLoS One. 7:e448022012. View Article : Google Scholar : PubMed/NCBI

50 

Niam M, Linn YC, Fook Chong S, et al: Clinical scale expansion of cytokine-induced killer cells is feasible from healthy donors and patients with acute and chronic myeloid leukemia at various stages of therapy. Exp Hematol. 39:897–903. 2011. View Article : Google Scholar : PubMed/NCBI

51 

Introna M, Borleri G, Conti E, et al: Repeated infusions of donor-derived cytokine-induced killer cells in patients relapsing after allogeneic stem cell transplantation: a phase I study. Haematologica. 92:952–959. 2007. View Article : Google Scholar : PubMed/NCBI

52 

Introna M, Pievani A, Borleri G, et al: Feasibility and safety of adoptive immunotherapy with CIK cells after cord blood transplantation. Biol Blood Marrow Transplant. 16:1603–1607. 2010. View Article : Google Scholar : PubMed/NCBI

53 

Linn YC, Niam M, Chu S, et al: The anti-tumour activity of allogeneic cytokine-induced killer cells in patients who relapse after allogeneic transplant for haematological malignancies. Bone Marrow Transplant. 47:957–966. 2012. View Article : Google Scholar

54 

Linn YC, Yong HX, Niam M, et al: A phase I/II clinical trial of autologous cytokine-induced killer cells as adjuvant immunotherapy for acute and chronic myeloid leukemia in clinical remission. Cytotherapy. 14:851–859. 2012. View Article : Google Scholar : PubMed/NCBI

55 

Zhong R, Teng J, Han B and Zhong H: Dendritic cells combining with cytokine-induced killer cells synergize chemotherapy in patients with late-stage non-small cell lung cancer. Cancer Immunol Immunother. 60:1497–1502. 2011. View Article : Google Scholar : PubMed/NCBI

56 

Jiang H, Liu KY, Tong CR, et al: The efficacy of chemotherapy in combination with auto-cytokine-induced killer cells in acute leukemia. Zhonghua Nei Ke Za Zhi. 44:198–201. 2005.(In Chinese). PubMed/NCBI

57 

Benjamin J, Laport GG, Tate K, Galvez L, et al: Early infusion of donor-derived CIK cells as consolidative immunotherapy following non-myeloablative allogeneic transplantation: safety and feasibility. Blood. 122:8992013.

58 

Zhou X, Zhu J, Sun H, et al: Family haploidentical donor-derived cytokine-induced killer cell biotherapy combined with bortezomib in two patients with relapsed multiple myeloma in a non-allogeneic transplant setting. Leukemia Lymphoma. 54:209–211. 2013. View Article : Google Scholar

59 

Hontscha C, Borck Y, Zhou H, et al: Clinical trials on CIK cells: first report of the international registry on CIK cells (IRCC). J Cancer Res Clin Oncol. 137:305–331. 2011. View Article : Google Scholar

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Yang XY, Zeng H and Chen FP: Cytokine-induced killer cells: A novel immunotherapy strategy for leukemia. Oncol Lett 9: 535-541, 2015.
APA
Yang, X., Zeng, H., & Chen, F. (2015). Cytokine-induced killer cells: A novel immunotherapy strategy for leukemia. Oncology Letters, 9, 535-541. https://doi.org/10.3892/ol.2014.2780
MLA
Yang, X., Zeng, H., Chen, F."Cytokine-induced killer cells: A novel immunotherapy strategy for leukemia". Oncology Letters 9.2 (2015): 535-541.
Chicago
Yang, X., Zeng, H., Chen, F."Cytokine-induced killer cells: A novel immunotherapy strategy for leukemia". Oncology Letters 9, no. 2 (2015): 535-541. https://doi.org/10.3892/ol.2014.2780
Copy and paste a formatted citation
x
Spandidos Publications style
Yang XY, Zeng H and Chen FP: Cytokine-induced killer cells: A novel immunotherapy strategy for leukemia. Oncol Lett 9: 535-541, 2015.
APA
Yang, X., Zeng, H., & Chen, F. (2015). Cytokine-induced killer cells: A novel immunotherapy strategy for leukemia. Oncology Letters, 9, 535-541. https://doi.org/10.3892/ol.2014.2780
MLA
Yang, X., Zeng, H., Chen, F."Cytokine-induced killer cells: A novel immunotherapy strategy for leukemia". Oncology Letters 9.2 (2015): 535-541.
Chicago
Yang, X., Zeng, H., Chen, F."Cytokine-induced killer cells: A novel immunotherapy strategy for leukemia". Oncology Letters 9, no. 2 (2015): 535-541. https://doi.org/10.3892/ol.2014.2780
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team