Quantitative analysis of the association between CRP rs2808630 and rs1417938 polymorphisms and cancer risk

Wang,Jian‑Gong; Zhang,Yang; Xiao,Tian‑Lin

doi:10.3892/ol.2014.2796

February-2015 Volume 9 Issue 2

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February-2015 Volume 9 Issue 2

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Article

Quantitative analysis of the association between CRP rs2808630 and rs1417938 polymorphisms and cancer risk

Authors:
- Jian‑Gong Wang
- Yang Zhang
- Tian‑Lin Xiao
View Affiliations / Copyright

Affiliations: Department of Cancer Biotherapy, Cancer Institute, Tangshan People's Hospital, Tangshan, Hebei 063001, P.R. China, Department of Oncology, Xiangyang Central Hospital, Medical College, Hubei University of Arts and Science, Xiangyang, Hubei 441000, P.R. China
Pages: 994-998
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Published online on: December 12, 2014

https://doi.org/10.3892/ol.2014.2796
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Abstract

Accumulating evidence indicates that polymorphisms in the CRP gene are important in the development of cancer. The current meta‑analysis was performed to investigate the association between CRP polymorphisms 3407 A>G (rs2808630) and 29 A>T (rs1417938), and the risk of developing cancer. A search of the relevant literature was conducted using the PubMed database to identify eligible studies published up until March 25, 2014. Five case‑control studies involving 888 cases and 3,167 controls for the 3407 A>G polymorphism, and six case‑control studies involving 3,110 cases and 5,951 controls for the 29 A>T polymorphism were included in the current meta‑analysis. The pooled odds ratios with 95% confidence intervals were calculated using the fixed‑ or random‑effects model. Meta‑analysis identified no association between the CRP 3407 A>G and 29 A>T polymorphisms, and overall cancer risk. Additional stratified analysis by cancer type did not reveal any significant associations in the genetic models investigated. The findings of the present study indicated that CRP 3407 A>G and 29 A>T polymorphisms are not associated with cancer risk.

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Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Quantitative analysis of the association between CRP rs2808630 and rs1417938 polymorphisms and cancer risk

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