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Article

Predictive value of vascular endothelial growth factor polymorphisms on the clinical outcome of renal cell carcinoma patients

  • Authors:
    • Nan Ma
    • Li‑Wei Li
    • Jing‑Liang Cheng
  • View Affiliations / Copyright

    Affiliations: Department of Interventional Radiography, The First Affiliated Hospital, Zhengzhou University, Zhengzhou, Henan 4500052, P.R. China, Department of Anesthesia, The First Affiliated Hospital, Zhengzhou University, Zhengzhou, Henan 4500052, P.R. China, Department of MRI, The First Affiliated Hospital, Zhengzhou University, Zhengzhou, Henan 4500052, P.R. China
  • Pages: 651-656
    |
    Published online on: December 12, 2014
       https://doi.org/10.3892/ol.2014.2798
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Abstract

A cohort study was conducted to investigate the association between vascular endothelial growth factor (VEGF) polymorphisms ‑2578C/A, ‑1154G/A and ‑634C/G and the clinical outcome of renal cell carcinoma (RCC), as well as the interaction of VEGF polymorphisms with tumor stage, metastasis and size. A total of 310 RCC patients were recruited from the First Affiliated Hospital of Zhengzhou University (Zhengzhou, China) between January 2006 and December 2007, and were followed up until December 2012. The association between the three single nucleotide polymorphisms and the overall survival of RCC patients was estimated using Cox's proportional hazard regression model. The median follow‑up duration was 34.7 months and 74 of the RCC patients succumbed due to cancer during the follow‑up period. The frequency of the VEGF ‑2578 AA genotype was significantly higher in patients classed as tumor stages III‑IV (odds ratio [OR], 0.47; 95% confidence interval [CI], 0.24‑0.95) and larger tumors (longest diameter, >4 cm; OR, 0.44; 95% CI, 0.22‑0.89). Furthermore, the frequency of VEGF ‑634 GG was significantly higher in patients with larger tumors (longest diameter, >4 cm; OR, 0.68; 95% CI, 0.48‑0.97). The VEGF ‑2578 AA genotype was correlated with a 2.96‑fold increase in the risk of RCC‑associated mortality and was associated with a five‑year survival rate of ~25%. Therefore, the present study identified that the VEGF ‑2578C/A polymorphism may be associated with the prognosis of RCC patients, and may interact with the tumor stage and size.
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1 

Jemal A, Siegel R, Ward E, et al: Cancer statistics, 2009. CA Cancer J Clin. 59:225–249. 2009. View Article : Google Scholar : PubMed/NCBI

2 

Motzer RJ, Hutson TE, Tomczak P, et al: Overall survival and updated results for sunitinib compared with interferon alfa in patients with metastatic renal cell carcinoma. J Clin Oncol. 27:3584–3590. 2009. View Article : Google Scholar : PubMed/NCBI

3 

Motzer RJ, Bander NH and Nanus DM: Renal-cell carcinoma. N Engl J Med. 335:865–875. 1996. View Article : Google Scholar : PubMed/NCBI

4 

Cao Q, Wang J, Zhang M, et al: Genetic Variants in RKIP Are Associated with Clear Cell Renal Cell Carcinoma Risk in a Chinese Population. PLoS One. 9:e1092852014. View Article : Google Scholar : PubMed/NCBI

5 

Mu HJ, Zou J, Xie P, Xu ZQ, Ruan J, Yang SD and Yin Y: Association of leptin receptor Lys109Arg and Gln223Arg polymorphisms with increased risk of clear cell renal cell carcinoma. Asian Pac J Cancer Prev. 15:4211–4215. 2014. View Article : Google Scholar : PubMed/NCBI

6 

Patard JJ, Pouessel D, Bensalah K and Culine S: Targeted therapy in renal cell carcinoma. World J Urol. 26:135–140. 2008. View Article : Google Scholar : PubMed/NCBI

7 

Motzer RJ, Hutson TE, Tomczak P, et al: Sunitinib versus interferon alfa in metastatic renal-cell carcinoma. N Engl J Med. 356:115–124. 2007. View Article : Google Scholar : PubMed/NCBI

8 

Vincenti V, Cassano C, Rocchi M and Persico G: Assignment of the vascular endothelial growth factor gene to human chromosome 6p21.3. Circulation. 93:1493–1495. 1996. View Article : Google Scholar : PubMed/NCBI

9 

Watson CJ, Webb NJ, Bottomley MJ and Brenchley PE: Identification of polymorphisms within the vascular endothelial growth factor (VEGF) gene: correlation with variation in VEGF protein production. Cytokine. 12:1232–1235. 2000. View Article : Google Scholar : PubMed/NCBI

10 

Koukourakis MI, Papazoglou D, Giatromanolaki A, et al: VEGF gene sequence variation defines VEGF gene expression status and angiogenic activity in non-small cell lung cancer. Lung Cancer. 46:293–298. 2004. View Article : Google Scholar : PubMed/NCBI

11 

Luo T, Chen L, He P, et al: Vascular endothelial growth factor (VEGF) gene polymorphisms and breast cancer risk in a Chinese population. Asian Pac J Cancer Prev. 14:2433–2437. 2013. View Article : Google Scholar : PubMed/NCBI

12 

Sivaprasad S, Govardhan B, Harithakrishna R, et al: Association of vascular endothelial growth factor (VEGF) gene polymorphism and increased serum VEGF concentration with pancreatic adenocarcinoma. Pancreatology. 13:267–272. 2013. View Article : Google Scholar : PubMed/NCBI

13 

Mandal RK, Yadav SS, Panda AK and Khattri S: Vascular endothelial growth factor 936 c>T polymorphism increased oral cancer risk: evidence from a meta-analysis. Genet Test Mol Biomarkers. 17:543–547. 2013. View Article : Google Scholar : PubMed/NCBI

14 

He D, Lu W, Chang K, et al: Vascular endothelial growth factor polymorphisms and risk of Alzheimer’s disease: a meta-analysis. Gene. 518:296–302. 2013. View Article : Google Scholar : PubMed/NCBI

15 

Garcia-Donas J, Rodriguez-Antona C and Jonasch E: Molecular markers to predict response to therapy. Semin Oncol. 40:444–458. 2013. View Article : Google Scholar : PubMed/NCBI

16 

Vrdoljak E, Rini B, Schmidinger M, et al: Bisphosphonates and vascular endothelial growth factor-targeted drugs in the treatment of patients with renal cell carcinoma metastatic to bone. Anticancer Drugs. 24:431–440. 2013. View Article : Google Scholar : PubMed/NCBI

17 

Jäkel CE, Hauser S, Rogenhofer S, et al: Clinical studies applying cytokine-induced killer cells for the treatment of renal cell carcinoma. Clin Dev Immunol. 2012:4732452012. View Article : Google Scholar : PubMed/NCBI

18 

Kawai Y, Sakano S, Korenaga Y, Eguchi S and Naito K: Associations of single nucleotide polymorphisms in the vascular endothelial growth factor gene with the characteristics and prognosis of renal cell carcinomas. Eur Urol. 52:1147–1155. 2007. View Article : Google Scholar : PubMed/NCBI

19 

Sáenz-López P, Vazquez F, Cozar JM, et al: VEGF polymorphisms are not associated with an increased risk of developing renal cell carcinoma in Spanish population. Hum Immunol. 74:98–103. 2013. View Article : Google Scholar

20 

Edge SB, Byrd DR, Compton CC, et al: Kidney. AJCC Cancer Staging Manual. 7th edition. Springer; New York, NY: pp. 2010479–2010489. 2010

21 

Abe A, Sato K, Habuchi T, et al: Single nucleotide polymorphisms in the 3′ untranslated region of vascular endothelial growth factor gene in Japanese population with or without renal cell carcinoma. Tohoku J Exp Med. 198:181–190. 2002. View Article : Google Scholar

22 

Salven P, Teerenhovi L and Joensuu H: A high pretreatment serum vascular endothelial growth factor concentration is associated with poor outcome in non-Hodgkin’s lymphoma. Blood. 90:3167–3172. 1997.PubMed/NCBI

23 

Martinez-Fierro ML, Garza-Veloz I, Rojas-Martinez A, et al: Positive association between vascular endothelial growth factor (VEGF) −2578 C/A variant and prostate cancer. Cancer Biomark. 13:235–241. 2013.

24 

Chen P, Zhu J, Liu DY, et al: Over-expression of survivin and VEGF in small-cell lung cancer may predict the poorer prognosis. Med Oncol. 31:7752014. View Article : Google Scholar

25 

Oh SY, Kwon HC, Kim SH, et al: The relationship of vascular endothelial growth factor gene polymorphisms and clinical outcome in advanced gastric cancer patients treated with FOLFOX: VEGF polymorphism in gastric cancer. BMC Cancer. 13:432013. View Article : Google Scholar : PubMed/NCBI

26 

Absenger G, Szkandera J, Stotz M, et al: A common and functional gene variant in the vascular endothelial growth factor a predicts clinical outcome in early-stage breast cancer. Mol Carcinog. 52(Suppl 1): E96–E102. 2013. View Article : Google Scholar : PubMed/NCBI

27 

Hefler LA, Mustea A, Könsgen D, et al: Vascular endothelial growth factor gene polymorphisms are associated with prognosis in ovarian cancer. Clin Cancer Res. 13:898–901. 2007. View Article : Google Scholar : PubMed/NCBI

28 

Shahbazi M, Fryer AA, Pravica V, et al: Vascular endothelial growth factor gene polymorphisms are associated with acute renal allograft rejection. J Am Soc Nephrol. 13:260–264. 2002.

29 

Sa-Nguanraksa D, Chuangsuwanich T, Pongpruttipan T, et al: Vascular endothelial growth factor −634G/C polymorphism is associated with increased breast cancer risk and aggressiveness. Mol Med Rep. 8:1242–1250. 2013.PubMed/NCBI

30 

Supic G, Jovic N, Zeljic K, Kozomara R and Magic Z: Association of VEGF-A genetic polymorphisms with cancer risk and survival in advanced-stage oral squamous cell carcinoma patients. Oral Oncol. 48:1171–1177. 2012. View Article : Google Scholar : PubMed/NCBI

31 

Jin Q, Hemminki K, Enquist K, et al: Vascular endothelial growth factor polymorphisms in relation to breast cancer development and prognosis. Clin Cancer Res. 11:3647–3653. 2005. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Ma N, Li LW and Cheng JL: Predictive value of vascular endothelial growth factor polymorphisms on the clinical outcome of renal cell carcinoma patients. Oncol Lett 9: 651-656, 2015.
APA
Ma, N., Li, L., & Cheng, J. (2015). Predictive value of vascular endothelial growth factor polymorphisms on the clinical outcome of renal cell carcinoma patients. Oncology Letters, 9, 651-656. https://doi.org/10.3892/ol.2014.2798
MLA
Ma, N., Li, L., Cheng, J."Predictive value of vascular endothelial growth factor polymorphisms on the clinical outcome of renal cell carcinoma patients". Oncology Letters 9.2 (2015): 651-656.
Chicago
Ma, N., Li, L., Cheng, J."Predictive value of vascular endothelial growth factor polymorphisms on the clinical outcome of renal cell carcinoma patients". Oncology Letters 9, no. 2 (2015): 651-656. https://doi.org/10.3892/ol.2014.2798
Copy and paste a formatted citation
x
Spandidos Publications style
Ma N, Li LW and Cheng JL: Predictive value of vascular endothelial growth factor polymorphisms on the clinical outcome of renal cell carcinoma patients. Oncol Lett 9: 651-656, 2015.
APA
Ma, N., Li, L., & Cheng, J. (2015). Predictive value of vascular endothelial growth factor polymorphisms on the clinical outcome of renal cell carcinoma patients. Oncology Letters, 9, 651-656. https://doi.org/10.3892/ol.2014.2798
MLA
Ma, N., Li, L., Cheng, J."Predictive value of vascular endothelial growth factor polymorphisms on the clinical outcome of renal cell carcinoma patients". Oncology Letters 9.2 (2015): 651-656.
Chicago
Ma, N., Li, L., Cheng, J."Predictive value of vascular endothelial growth factor polymorphisms on the clinical outcome of renal cell carcinoma patients". Oncology Letters 9, no. 2 (2015): 651-656. https://doi.org/10.3892/ol.2014.2798
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