T-cell acute lymphoid leukemia resembling Burkitt leukemia cell morphology: A case report

Yue,Qingfang; Liu,Xinyue; Chen,Lei; Liu,Zhongping; Chen,Wanxin

doi:10.3892/ol.2014.2825

March-2015 Volume 9 Issue 3

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March-2015 Volume 9 Issue 3

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Case Report

T-cell acute lymphoid leukemia resembling Burkitt leukemia cell morphology: A case report

Authors:
- Qingfang Yue
- Xinyue Liu
- Lei Chen
- Zhongping Liu
- Wanxin Chen
View Affiliations / Copyright

Affiliations: Department of Hematology, Union Hospital, Tongji Medical College of Huazhong University of Science and Technology, Wuhan, Hubei 430022, P.R. China
Pages: 1236-1238
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Published online on: December 23, 2014

https://doi.org/10.3892/ol.2014.2825
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Abstract

Biphenotypic acute leukemia (BAL) is an uncommon type of cancer, which accounts for <5% of all adult ALs. Based upon a previously described scoring system, the European Group for the Immunological Classification of Leukemias (EGIL) proposed a set of diagnostic criteria for BAL. This scoring system is based upon the number and degree of specificity of several markers for myeloid or T/B‑lymphoid blasts. The present study describes a case of T‑cell acute lymphoblastic leukemia (T‑ALL) with Burkitt‑like cytology, which according to the French‑American‑British classification, corresponded to a diagnosis of Burkitt type L3 ALL. Flow cytometry analysis demonstrated that the blasts were positive for T‑lymphoid markers, cytoplasmic cluster of differentiation (CD)3, CD7 and CD56, and myeloid markers, CD13, CD33 and CD15. At first, a diagnosis of BAL was suggested by the EGIL score, however, according to the 2008 World Health Organization criteria, a case of T‑ALL with aberrant myeloid markers was established. The study also reviewed the literature and discussed the limitations of the EGIL scoring system in clinical decision making, to aid in the selection of an appropriate therapeutic regimen.

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Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

T-cell acute lymphoid leukemia resembling Burkitt leukemia cell morphology: A case report

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Abstract

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